Mutagenetix > Incidental Mutation

Incidental Mutation 'R1165:Gm14410'

262427

Institutional Source

Beutler Lab

Gene Symbol

Gm14410

Ensembl Gene

ENSMUSG00000078870

Gene Name

predicted gene 14410

Synonyms

MMRRC Submission

039238-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R1165 (G1)

Quality Score

101

Status

Not validated

Chromosome

Chromosomal Location

176882368-176898289 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to C at 176885282 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 327 (Y327*)

Ref Sequence

ENSEMBL: ENSMUSP00000114668 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108964] [ENSMUST00000133301]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000108964

SMART Domains

Protein: ENSMUSP00000104592
Gene: ENSMUSG00000078870

Domain	Start	End	E-Value	Type
KRAB	4	64	1.47e-12	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000133301
AA Change: Y327*

SMART Domains

Protein: ENSMUSP00000114668
Gene: ENSMUSG00000078870
AA Change: Y327*

Domain	Start	End	E-Value	Type
KRAB	4	66	1.84e-13	SMART
ZnF_C2H2	78	97	1.61e2	SMART
ZnF_C2H2	103	125	4.17e-3	SMART
ZnF_C2H2	131	153	9.58e-3	SMART
ZnF_C2H2	159	181	5.67e-5	SMART
ZnF_C2H2	187	209	4.01e-5	SMART
ZnF_C2H2	215	237	5.99e-4	SMART
ZnF_C2H2	243	265	8.47e-4	SMART
ZnF_C2H2	271	293	1.67e-2	SMART
ZnF_C2H2	299	321	3.89e-3	SMART
ZnF_C2H2	327	349	1.82e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156269

Coding Region Coverage

1x: 99.1%
3x: 98.2%
10x: 96.0%
20x: 91.4%

Validation Efficiency

98% (50/51)

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	T	G	13: 77,482,406 (GRCm39)	C1209G	probably benign	Het
Abcg2	C	A	6: 58,655,285 (GRCm39)	L407I	probably benign	Het
Adtrp	A	G	13: 41,967,779 (GRCm39)	V56A	probably damaging	Het
Angptl6	T	G	9: 20,789,604 (GRCm39)	N96T	probably benign	Het
Ank3	C	A	10: 69,734,132 (GRCm39)	N780K	possibly damaging	Het
AU040320	A	T	4: 126,717,433 (GRCm39)		probably benign	Het
Best2	C	T	8: 85,737,789 (GRCm39)	R202H	probably benign	Het
Bod1l	A	T	5: 41,978,396 (GRCm39)	S973T	probably benign	Het
Brca2	T	A	5: 150,466,212 (GRCm39)	V1992E	probably damaging	Het
Casp8ap2	C	T	4: 32,640,563 (GRCm39)	P539L	probably benign	Het
Ccr1	A	T	9: 123,763,531 (GRCm39)	V333E	possibly damaging	Het
Celf5	A	T	10: 81,307,172 (GRCm39)	V83E	probably damaging	Het
Col15a1	T	C	4: 47,257,275 (GRCm39)		probably benign	Het
Coro1b	C	A	19: 4,199,901 (GRCm39)	H81N	probably damaging	Het
Cwc22	A	T	2: 77,734,242 (GRCm39)	S686T	probably damaging	Het
Cyp2d26	C	A	15: 82,678,242 (GRCm39)	G45W	probably damaging	Het
Dysf	T	A	6: 84,044,051 (GRCm39)	N297K	probably damaging	Het
Edem1	T	A	6: 108,828,214 (GRCm39)	L513Q	probably damaging	Het
Erich1	G	A	8: 14,140,530 (GRCm39)		probably benign	Het
Fam91a1	T	C	15: 58,302,518 (GRCm39)	V286A	possibly damaging	Het
Fdxr	C	A	11: 115,162,608 (GRCm39)		probably benign	Het
Gas7	T	C	11: 67,561,512 (GRCm39)		probably benign	Het
Glb1l2	T	C	9: 26,705,397 (GRCm39)	D151G	probably damaging	Het
Grep1	A	C	17: 23,929,489 (GRCm39)		probably benign	Het
H6pd	A	G	4: 150,080,413 (GRCm39)	I136T	possibly damaging	Het
Hectd1	A	T	12: 51,810,947 (GRCm39)		probably benign	Het
Hipk1	T	C	3: 103,668,840 (GRCm39)	T519A	possibly damaging	Het
Hpd	A	G	5: 123,314,153 (GRCm39)		probably null	Het
Insyn2b	A	G	11: 34,352,740 (GRCm39)	T261A	probably benign	Het
Or6c76	A	G	10: 129,612,302 (GRCm39)	D188G	probably damaging	Het
Or7c19	T	A	8: 85,957,400 (GRCm39)	I92N	probably damaging	Het
Pcdha11	A	G	18: 37,140,757 (GRCm39)		probably benign	Het
Pdgfrb	T	C	18: 61,197,074 (GRCm39)	I170T	probably benign	Het
Rasgrp1	A	T	2: 117,115,420 (GRCm39)	F723I	possibly damaging	Het
Retnlg	A	G	16: 48,694,017 (GRCm39)	T58A	possibly damaging	Het
Rrs1	G	A	1: 9,615,992 (GRCm39)	E82K	probably damaging	Het
Rtel1	A	G	2: 180,976,732 (GRCm39)	K243E	probably benign	Het
Slc19a2	G	A	1: 164,091,014 (GRCm39)	G274D	probably damaging	Het
Slc22a27	T	C	19: 7,887,059 (GRCm39)		probably null	Het
Slc6a1	T	C	6: 114,288,790 (GRCm39)	F266L	probably damaging	Het
Snx25	T	G	8: 46,488,752 (GRCm39)	I868L	probably damaging	Het
Spag16	A	G	1: 70,036,036 (GRCm39)	I355V	probably benign	Het
Tmem198	A	T	1: 75,456,576 (GRCm39)		probably benign	Het
Traf3ip3	A	C	1: 192,866,786 (GRCm39)	S349A	probably damaging	Het
Trim17	A	G	11: 58,862,041 (GRCm39)	N358D	possibly damaging	Het
Trmu	A	G	15: 85,776,875 (GRCm39)	T196A	probably damaging	Het
Tsen2	A	G	6: 115,538,396 (GRCm39)	Y291C	probably damaging	Het
Vps13d	A	G	4: 144,853,041 (GRCm39)	F2358L	probably benign	Het
Wnt2	T	C	6: 17,989,946 (GRCm39)	H317R	probably benign	Het
Zfp120	A	T	2: 149,961,849 (GRCm39)	V33E	probably damaging	Het
Zfp407	C	T	18: 84,577,898 (GRCm39)	A1072T	probably benign	Het

Other mutations in Gm14410

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4528:Gm14410	UTSW	2	176,885,736 (GRCm39)	missense	probably benign	0.00
R4528:Gm14410	UTSW	2	176,885,734 (GRCm39)	missense	probably damaging	1.00
R4591:Gm14410	UTSW	2	176,885,820 (GRCm39)	missense	possibly damaging	0.53
R5321:Gm14410	UTSW	2	176,885,298 (GRCm39)	missense	probably damaging	0.96
R6247:Gm14410	UTSW	2	176,885,517 (GRCm39)	missense	probably damaging	0.99
R6528:Gm14410	UTSW	2	176,885,301 (GRCm39)	missense	probably damaging	0.99
R6863:Gm14410	UTSW	2	176,885,860 (GRCm39)	nonsense	probably null
R7302:Gm14410	UTSW	2	176,885,648 (GRCm39)	missense	probably damaging	1.00
R7474:Gm14410	UTSW	2	176,894,618 (GRCm39)	critical splice donor site	probably null
R7761:Gm14410	UTSW	2	176,885,527 (GRCm39)	missense	probably benign	0.09
R7799:Gm14410	UTSW	2	176,885,613 (GRCm39)	missense	probably damaging	1.00
R8560:Gm14410	UTSW	2	176,885,445 (GRCm39)	missense	probably damaging	1.00
R9594:Gm14410	UTSW	2	176,885,773 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

Posted On

2015-02-04