Incidental Mutation 'IGL02901:Nxf7'
ID363614
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nxf7
Ensembl Gene ENSMUSG00000031410
Gene Namenuclear RNA export factor 7
Synonymsnfx-a1, nxf-a2
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL02901
Quality Score
Status
ChromosomeX
Chromosomal Location135579555-135598777 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 135587235 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000033784] [ENSMUST00000033784] [ENSMUST00000113163] [ENSMUST00000113163] [ENSMUST00000141310] [ENSMUST00000150900]
Predicted Effect probably null
Transcript: ENSMUST00000033784
SMART Domains Protein: ENSMUSP00000033784
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 116 203 1.9e-42 PFAM
low complexity region 269 280 N/A INTRINSIC
Pfam:LRR_4 294 346 9.2e-8 PFAM
Pfam:NTF2 389 537 1.1e-12 PFAM
TAP_C 557 620 5.03e-26 SMART
Predicted Effect probably null
Transcript: ENSMUST00000033784
SMART Domains Protein: ENSMUSP00000033784
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 116 203 1.9e-42 PFAM
low complexity region 269 280 N/A INTRINSIC
Pfam:LRR_4 294 346 9.2e-8 PFAM
Pfam:NTF2 389 537 1.1e-12 PFAM
TAP_C 557 620 5.03e-26 SMART
Predicted Effect probably null
Transcript: ENSMUST00000113163
SMART Domains Protein: ENSMUSP00000108788
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 119 202 4.8e-37 PFAM
low complexity region 269 280 N/A INTRINSIC
Pfam:NTF2 389 537 1.8e-12 PFAM
TAP_C 557 620 5.03e-26 SMART
Predicted Effect probably null
Transcript: ENSMUST00000113163
SMART Domains Protein: ENSMUSP00000108788
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 119 202 4.8e-37 PFAM
low complexity region 269 280 N/A INTRINSIC
Pfam:NTF2 389 537 1.8e-12 PFAM
TAP_C 557 620 5.03e-26 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127202
Predicted Effect probably null
Transcript: ENSMUST00000137977
SMART Domains Protein: ENSMUSP00000122993
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 10 93 9.6e-38 PFAM
Pfam:NTF2 244 392 2.6e-13 PFAM
TAP_C 412 475 5.03e-26 SMART
Predicted Effect probably null
Transcript: ENSMUST00000137977
SMART Domains Protein: ENSMUSP00000122993
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 10 93 9.6e-38 PFAM
Pfam:NTF2 244 392 2.6e-13 PFAM
TAP_C 412 475 5.03e-26 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000141310
SMART Domains Protein: ENSMUSP00000117622
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 106 127 2.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000150900
SMART Domains Protein: ENSMUSP00000119764
Gene: ENSMUSG00000031410

DomainStartEndE-ValueType
Pfam:Tap-RNA_bind 106 156 1.3e-27 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired spatial learning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adra1d A T 2: 131,561,604 Y189N probably damaging Het
Ahdc1 A G 4: 133,064,934 D1162G possibly damaging Het
Alpk2 A G 18: 65,306,411 M637T probably benign Het
Arvcf G A 16: 18,398,242 A440T probably damaging Het
BC051665 A T 13: 60,784,718 V51E probably damaging Het
Clca3a2 A T 3: 144,816,768 V164E probably damaging Het
Cox6a2 A C 7: 128,206,282 L5R probably damaging Het
Cpsf1 A T 15: 76,599,496 L849* probably null Het
Dclk1 A G 3: 55,487,787 probably benign Het
Fam120b T A 17: 15,407,702 probably benign Het
Iqub A G 6: 24,454,195 L563P probably damaging Het
Itgb3 A T 11: 104,637,946 I300F probably benign Het
Mdga2 A G 12: 66,797,809 probably benign Het
Mfsd6 A G 1: 52,708,473 I411T probably benign Het
Misp A T 10: 79,826,937 Y396F possibly damaging Het
Nhsl2 T A X: 102,079,243 V884D probably benign Het
Olfr120 T A 17: 37,726,420 I132K probably damaging Het
Olfr1271 G A 2: 90,265,708 H241Y probably damaging Het
Palld T A 8: 61,876,995 K283* probably null Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Proc T G 18: 32,123,625 T330P possibly damaging Het
Prpf38a T C 4: 108,568,418 D221G probably damaging Het
Prss55 T A 14: 64,077,127 N198I probably damaging Het
Rabggta A G 14: 55,721,681 S10P probably benign Het
Sbk2 A G 7: 4,957,290 Y294H possibly damaging Het
Smyd1 A G 6: 71,238,630 V115A probably benign Het
Trpm7 A G 2: 126,807,287 probably null Het
Ttc21a A G 9: 119,958,281 N751S probably damaging Het
Upk1a A T 7: 30,603,779 M241K possibly damaging Het
Vmn2r71 A C 7: 85,619,262 E224D probably benign Het
Vmn2r81 C T 10: 79,270,730 T514I probably damaging Het
Zkscan16 T C 4: 58,946,283 W53R probably damaging Het
Other mutations in Nxf7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02965:Nxf7 APN X 135589410 missense probably damaging 1.00
IGL03388:Nxf7 APN X 135584740 missense probably damaging 0.97
R0389:Nxf7 UTSW X 135584383 missense possibly damaging 0.58
Z1177:Nxf7 UTSW X 135588025 missense probably benign
Posted On2015-12-18