Incidental Mutation 'IGL01070:Trac'
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ID52653
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trac
Ensembl Gene ENSMUSG00000076928
Gene NameT cell receptor alpha constant
SynonymsGm16914, Tcra-C
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01070
Quality Score
Status
Chromosome14
Chromosomal Location54220521-54223097 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 54220766 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 82 (T82A)
Gene Model predicted gene model for transcript(s):
Predicted Effect probably benign
Transcript: ENSMUST00000103736
Predicted Effect probably benign
Transcript: ENSMUST00000103737
Predicted Effect probably benign
Transcript: ENSMUST00000103738
Predicted Effect noncoding transcript
Transcript: ENSMUST00000103739
Predicted Effect probably benign
Transcript: ENSMUST00000103740
AA Change: T82A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000100459
Gene: ENSMUSG00000076928
AA Change: T82A

DomainStartEndE-ValueType
Pfam:DUF1968 7 88 1.6e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000198398
AA Change: T82A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
Adamts5 T C 16: 85,863,133 H757R probably damaging Het
Aen G A 7: 78,907,302 M299I probably damaging Het
Akap3 A T 6: 126,865,879 E487V possibly damaging Het
Bicd2 T C 13: 49,378,316 S271P probably damaging Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Cma1 A G 14: 55,942,697 S71P probably benign Het
Cspp1 T C 1: 10,088,145 Y494H probably damaging Het
Cyp39a1 A G 17: 43,683,022 K191R probably benign Het
Efr3a G A 15: 65,853,078 V507I probably benign Het
Fam178b C T 1: 36,564,403 R489Q possibly damaging Het
Kcnj4 A G 15: 79,484,579 L400P probably benign Het
Kif27 A G 13: 58,344,093 Y411H probably damaging Het
Mstn A T 1: 53,061,997 I78L possibly damaging Het
Nrap T C 19: 56,329,084 D1377G probably damaging Het
Pramel5 T G 4: 144,271,272 Y467S probably damaging Het
Prkg1 G A 19: 30,569,343 probably benign Het
Rbfox1 A C 16: 7,306,443 S219R possibly damaging Het
Rfng T C 11: 120,783,952 N71D probably damaging Het
Rp1 T C 1: 4,345,238 I1884V probably damaging Het
Rptn T A 3: 93,398,176 Y939N possibly damaging Het
Sart1 A G 19: 5,383,951 V322A probably benign Het
Shank3 T C 15: 89,549,416 S1455P probably damaging Het
Smc5 T A 19: 23,231,601 R703W possibly damaging Het
Sptan1 G A 2: 30,014,173 probably null Het
Tecta T C 9: 42,395,003 D43G probably damaging Het
Tmem67 A T 4: 12,054,750 M685K probably benign Het
Trank1 A G 9: 111,366,793 N1295S probably damaging Het
Ttc36 T C 9: 44,801,590 probably null Het
Utp18 A T 11: 93,869,848 S384T possibly damaging Het
Vmn1r64 C A 7: 5,883,942 A201S probably benign Het
Vmn2r26 A T 6: 124,061,607 I714F probably benign Het
Vps54 T A 11: 21,312,268 V626D probably damaging Het
Wapl T C 14: 34,745,622 probably benign Het
Yars2 C T 16: 16,306,542 R338* probably null Het
Other mutations in Trac
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01735:Trac APN 14 54222981 splice site probably benign
R6868:Trac UTSW 14 54220592 unclassified probably benign
R7983:Trac UTSW 14 54220757 missense
R8112:Trac UTSW 14 54223100 critical splice donor site probably benign
Z1177:Trac UTSW 14 54220539 missense
Z1177:Trac UTSW 14 54220668 missense
Posted On2013-06-21