Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01161:Gpr119'

54109

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr119

Ensembl Gene

ENSMUSG00000051209

Gene Name

G-protein coupled receptor 119

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01161

Quality Score

Status

Chromosome

Chromosomal Location

47756856-47763355 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to T at 47762125 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000060591 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053970]

AlphaFold

Q7TQP3

Predicted Effect

probably benign
Transcript: ENSMUST00000053970

SMART Domains

Protein: ENSMUSP00000060591
Gene: ENSMUSG00000051209

Domain	Start	End	E-Value	Type
Pfam:7tm_1	21	279	1.3e-34	PFAM
Pfam:7TM_GPCR_Srsx	38	294	1e-6	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal growth and glucose homeostasis except lowered body weight when fed a low-fat diet and decreased insulin levels post-glucose load. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abtb2	T	A	2: 103,535,463 (GRCm39)	D543E	probably benign	Het
Acad9	A	C	3: 36,144,274 (GRCm39)	N583T	possibly damaging	Het
Arhgap5	G	A	12: 52,563,643 (GRCm39)	V205M	probably damaging	Het
Arid1b	G	A	17: 5,392,674 (GRCm39)	R2068Q	probably damaging	Het
Bex3	T	C	X: 135,172,218 (GRCm39)	F60S	probably damaging	Het
Casd1	C	T	6: 4,619,833 (GRCm39)	P193S	possibly damaging	Het
Ceacam11	A	T	7: 17,712,435 (GRCm39)	I295F	possibly damaging	Het
Ceacam3	T	A	7: 16,885,782 (GRCm39)	N128K	probably benign	Het
Cyp1a2	C	T	9: 57,587,176 (GRCm39)	E372K	probably damaging	Het
Ddb1	T	G	19: 10,583,071 (GRCm39)	M1R	probably null	Het
Ecel1	T	C	1: 87,080,915 (GRCm39)	D329G	possibly damaging	Het
Fat2	T	C	11: 55,175,017 (GRCm39)	N1899D	probably benign	Het
Gli3	A	G	13: 15,722,983 (GRCm39)		probably null	Het
Gm20507	A	T	17: 33,863,727 (GRCm39)		probably benign	Het
Gml	T	G	15: 74,685,688 (GRCm39)	Y99S	probably damaging	Het
Hcn1	T	C	13: 117,793,458 (GRCm39)	Y237H	unknown	Het
Hook2	G	A	8: 85,721,560 (GRCm39)	V273I	probably benign	Het
Il12rb2	T	C	6: 67,338,849 (GRCm39)		probably benign	Het
Kdm2a	A	G	19: 4,369,279 (GRCm39)	F1112S	probably benign	Het
Lpl	A	T	8: 69,345,277 (GRCm39)	K94*	probably null	Het
Lrrc8a	T	A	2: 30,145,822 (GRCm39)	L212Q	probably damaging	Het
Me2	A	T	18: 73,903,887 (GRCm39)		probably benign	Het
Mmp11	A	T	10: 75,762,655 (GRCm39)	M266K	probably benign	Het
Mprip	T	A	11: 59,622,399 (GRCm39)	V162E	possibly damaging	Het
Nsf	C	T	11: 103,752,711 (GRCm39)		probably benign	Het
Or56b2	T	C	7: 104,337,588 (GRCm39)	V122A	probably benign	Het
Pcif1	T	A	2: 164,727,708 (GRCm39)	L167H	probably damaging	Het
Reps1	T	C	10: 17,969,643 (GRCm39)	S249P	probably damaging	Het
Sdf4	T	A	4: 156,093,763 (GRCm39)	M299K	probably benign	Het
Slc30a7	A	G	3: 115,747,759 (GRCm39)	V344A	possibly damaging	Het
Svep1	G	A	4: 58,146,569 (GRCm39)	P358S	probably damaging	Het
Syt9	G	T	7: 107,024,356 (GRCm39)	R83L	probably damaging	Het
Tbc1d15	T	C	10: 115,038,435 (GRCm39)	I593V	probably benign	Het
Trio	T	A	15: 27,749,867 (GRCm39)	N1134I	probably damaging	Het
Trpv3	A	G	11: 73,187,544 (GRCm39)		probably benign	Het
Ugp2	T	A	11: 21,273,273 (GRCm39)	I449L	possibly damaging	Het
Usp24	C	A	4: 106,294,041 (GRCm39)	H2595N	probably benign	Het
Vat1l	A	G	8: 115,096,629 (GRCm39)	N370S	possibly damaging	Het
Wwc1	C	A	11: 35,758,103 (GRCm39)	D748Y	probably damaging	Het
Zfyve9	G	A	4: 108,538,261 (GRCm39)	H1002Y	probably damaging	Het

Other mutations in Gpr119

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00816:Gpr119	APN	X	47,763,047 (GRCm39)	missense	probably damaging	0.99
R8816:Gpr119	UTSW	X	47,762,276 (GRCm39)	missense	possibly damaging	0.47

Posted On

2013-06-28