Incidental Mutation 'IGL01328:Htatip2'
ID74406
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Htatip2
Ensembl Gene ENSMUSG00000039745
Gene NameHIV-1 Tat interactive protein 2
SynonymsTIP30
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.537) question?
Stock #IGL01328
Quality Score
Status
Chromosome7
Chromosomal Location49759115-49773975 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to A at 49770949 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000146858 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085272] [ENSMUST00000085272] [ENSMUST00000207895] [ENSMUST00000207895]
Predicted Effect probably null
Transcript: ENSMUST00000085272
SMART Domains Protein: ENSMUSP00000082374
Gene: ENSMUSG00000039745

DomainStartEndE-ValueType
Pfam:Semialdhyde_dh 20 116 2.1e-8 PFAM
Pfam:NAD_binding_10 46 214 2.4e-14 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000085272
SMART Domains Protein: ENSMUSP00000082374
Gene: ENSMUSG00000039745

DomainStartEndE-ValueType
Pfam:Semialdhyde_dh 20 116 2.1e-8 PFAM
Pfam:NAD_binding_10 46 214 2.4e-14 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000207895
Predicted Effect probably null
Transcript: ENSMUST00000207895
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Inactivation of this gene increases susceptibility to tumorigenesis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 C T 18: 59,048,882 S1131F possibly damaging Het
Alg14 G A 3: 121,361,583 V151I probably benign Het
Ano5 G A 7: 51,556,271 probably null Het
Arhgef28 A T 13: 97,970,323 C698S probably damaging Het
Cacnb4 T C 2: 52,464,625 H247R probably damaging Het
Clec12b A T 6: 129,379,554 W216R probably damaging Het
Clnk C T 5: 38,784,528 S35N possibly damaging Het
Cnot4 T A 6: 35,078,114 N80I probably damaging Het
Cntn5 C T 9: 9,781,768 M635I probably damaging Het
Dlg5 A G 14: 24,202,351 V107A probably damaging Het
Dsc2 A T 18: 20,048,286 F155I probably damaging Het
Dtwd1 A G 2: 126,164,819 I254V probably damaging Het
Dzip3 A T 16: 48,972,258 D221E probably damaging Het
F13b T A 1: 139,508,082 probably benign Het
Fam131b G A 6: 42,318,272 L324F probably damaging Het
Fam83a A T 15: 57,986,505 R148S probably damaging Het
Farsb T C 1: 78,471,092 I236V probably benign Het
Fat4 T A 3: 38,980,658 F2820I probably damaging Het
Fat4 T A 3: 38,889,991 V1011E probably damaging Het
Fgf7 A G 2: 126,088,244 E99G probably damaging Het
Fign T C 2: 63,978,872 T685A probably damaging Het
Fubp1 G A 3: 152,220,218 G289E probably damaging Het
Gata6 G T 18: 11,064,530 M477I probably damaging Het
Gm14496 A G 2: 181,995,880 Y249C probably damaging Het
Hectd1 T C 12: 51,761,121 D1768G probably damaging Het
Irs2 C A 8: 11,004,792 Q1213H probably damaging Het
Jak3 C T 8: 71,679,620 R210C probably damaging Het
Klk1b27 T C 7: 44,055,879 S157P probably damaging Het
Klri1 T C 6: 129,698,837 S157G probably damaging Het
Mtmr2 G T 9: 13,801,927 G395* probably null Het
Mx1 T A 16: 97,455,632 I116F probably damaging Het
Oip5 A C 2: 119,611,833 M200R possibly damaging Het
Olfr1118 T A 2: 87,309,581 L284Q possibly damaging Het
Olfr1285 A G 2: 111,409,219 Y268C probably damaging Het
Olfr1512 T C 14: 52,372,510 D181G probably damaging Het
Olfr32 T C 2: 90,139,074 K22E probably benign Het
Pamr1 T A 2: 102,642,137 S594T probably benign Het
Phf13 C T 4: 151,995,828 E13K probably benign Het
Plekha6 A T 1: 133,272,336 probably null Het
Rad17 A C 13: 100,617,803 N636K probably benign Het
Rad21 T A 15: 51,973,124 D217V probably damaging Het
Slc7a10 A G 7: 35,186,492 D4G possibly damaging Het
Stc1 A G 14: 69,038,277 D173G probably benign Het
Supt16 C T 14: 52,177,032 E438K probably benign Het
Tex15 C T 8: 33,571,396 Q559* probably null Het
Trim44 T A 2: 102,400,020 E222V probably benign Het
Ubr5 T C 15: 37,981,523 E2343G possibly damaging Het
Vmn2r86 T C 10: 130,452,496 T379A possibly damaging Het
Vmn2r93 A G 17: 18,325,557 T564A probably benign Het
Vsir C A 10: 60,367,760 probably benign Het
Vwc2l T A 1: 70,729,004 probably null Het
Xrn2 T C 2: 147,029,930 V396A possibly damaging Het
Zbbx T A 3: 75,093,075 K208* probably null Het
Zfhx4 C A 3: 5,244,284 L857M probably damaging Het
Zfp180 A G 7: 24,101,479 D53G probably benign Het
Other mutations in Htatip2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01417:Htatip2 APN 7 49770825 missense possibly damaging 0.61
IGL03095:Htatip2 APN 7 49759774 missense probably benign 0.01
R0084:Htatip2 UTSW 7 49759672 missense probably damaging 1.00
R0349:Htatip2 UTSW 7 49773392 missense probably benign 0.00
R0631:Htatip2 UTSW 7 49773311 missense possibly damaging 0.84
R4612:Htatip2 UTSW 7 49772597 nonsense probably null
R4688:Htatip2 UTSW 7 49773423 missense probably damaging 1.00
R4715:Htatip2 UTSW 7 49770844 missense probably damaging 1.00
R6074:Htatip2 UTSW 7 49772574 critical splice acceptor site probably null
R6207:Htatip2 UTSW 7 49770819 missense probably benign 0.00
R6862:Htatip2 UTSW 7 49770918 missense probably benign 0.00
R7016:Htatip2 UTSW 7 49770835 missense possibly damaging 0.64
R7225:Htatip2 UTSW 7 49770856 missense possibly damaging 0.74
R7242:Htatip2 UTSW 7 49772606 missense probably benign 0.00
R7408:Htatip2 UTSW 7 49759786 missense probably benign 0.22
R7452:Htatip2 UTSW 7 49773326 missense probably benign 0.01
R7718:Htatip2 UTSW 7 49770884 missense possibly damaging 0.54
Posted On2013-10-07