Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00818:Zranb3'

15054

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zranb3

Ensembl Gene

ENSMUSG00000036086

Gene Name

zinc finger, RAN-binding domain containing 3

Synonyms

4933425L19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.146) question?

Stock #

IGL00818

Quality Score

Status

Chromosome

Chromosomal Location

127881921-128030784 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 127960604 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 220 (Y220C)

Ref Sequence

ENSEMBL: ENSMUSP00000108157 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086614] [ENSMUST00000112538]

AlphaFold

Q6NZP1

Predicted Effect

probably damaging
Transcript: ENSMUST00000086614
AA Change: Y220C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000083806
Gene: ENSMUSG00000036086
AA Change: Y220C

Domain	Start	End	E-Value	Type
DEXDc	33	214	3.37e-19	SMART
HELICc	352	435	3.79e-13	SMART
ZnF_RBZ	619	643	6.93e-5	SMART
HNHc	985	1036	5.64e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000097597

SMART Domains

Protein: ENSMUSP00000095204
Gene: ENSMUSG00000036086

Domain	Start	End	E-Value	Type
DEXDc	33	214	3.37e-19	SMART
HELICc	352	435	3.79e-13	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000112538
AA Change: Y220C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000108157
Gene: ENSMUSG00000036086
AA Change: Y220C

Domain	Start	End	E-Value	Type
Pfam:SNF2_N	40	98	6.6e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127393

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap13	A	G	7: 75,259,475 (GRCm39)	T700A	probably benign	Het
Brinp1	T	A	4: 68,681,084 (GRCm39)	D482V	probably damaging	Het
Cmtr2	A	T	8: 110,949,732 (GRCm39)	T681S	probably benign	Het
Dcc	T	A	18: 72,088,083 (GRCm39)	M52L	probably benign	Het
Echdc1	A	G	10: 29,193,616 (GRCm39)	I38V	probably benign	Het
Gars1	G	T	6: 55,027,338 (GRCm39)	G144V	probably damaging	Het
Gp2	T	C	7: 119,049,350 (GRCm39)	T396A	possibly damaging	Het
Gpatch1	T	C	7: 34,976,238 (GRCm39)		probably null	Het
Mfap4	A	T	11: 61,378,607 (GRCm39)	Q209L	possibly damaging	Het
Pdcd2l	A	T	7: 33,884,158 (GRCm39)	M348K	possibly damaging	Het
Prkdc	A	T	16: 15,577,618 (GRCm39)	T2391S	possibly damaging	Het
Rxrg	C	T	1: 167,454,857 (GRCm39)		probably benign	Het
Serpinb2	A	G	1: 107,452,466 (GRCm39)	D348G	probably benign	Het
Tbc1d30	G	A	10: 121,102,729 (GRCm39)		probably benign	Het
Tmtc3	T	A	10: 100,307,342 (GRCm39)	T221S	probably benign	Het
Tro	C	T	X: 149,431,357 (GRCm39)	G1203D	probably damaging	Het
Ttn	T	A	2: 76,552,092 (GRCm39)	T31182S	probably damaging	Het

Other mutations in Zranb3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00565:Zranb3	APN	1	127,943,877 (GRCm39)	missense	probably benign	0.01
IGL01360:Zranb3	APN	1	127,887,622 (GRCm39)	nonsense	probably null
IGL01704:Zranb3	APN	1	127,895,676 (GRCm39)	missense	possibly damaging	0.93
IGL02131:Zranb3	APN	1	127,920,688 (GRCm39)	missense	probably damaging	1.00
IGL02466:Zranb3	APN	1	127,943,829 (GRCm39)	missense	probably benign	0.08
IGL02825:Zranb3	APN	1	127,887,489 (GRCm39)	missense	probably benign	0.13
IGL02836:Zranb3	APN	1	127,888,562 (GRCm39)	missense	probably benign	0.00
R0088:Zranb3	UTSW	1	127,904,199 (GRCm39)	missense	probably benign
R0279:Zranb3	UTSW	1	127,891,510 (GRCm39)	missense	probably benign	0.01
R0423:Zranb3	UTSW	1	128,019,607 (GRCm39)	missense	probably damaging	1.00
R0499:Zranb3	UTSW	1	127,882,817 (GRCm39)	splice site	probably null
R0562:Zranb3	UTSW	1	127,964,295 (GRCm39)	missense	probably benign	0.04
R0972:Zranb3	UTSW	1	127,884,383 (GRCm39)	missense	probably damaging	1.00
R1480:Zranb3	UTSW	1	128,019,599 (GRCm39)	missense	probably damaging	1.00
R1552:Zranb3	UTSW	1	127,888,488 (GRCm39)	splice site	probably benign
R1704:Zranb3	UTSW	1	128,019,740 (GRCm39)	start codon destroyed	probably null	0.22
R1817:Zranb3	UTSW	1	127,945,293 (GRCm39)	critical splice donor site	probably null
R1818:Zranb3	UTSW	1	127,945,293 (GRCm39)	critical splice donor site	probably null
R1819:Zranb3	UTSW	1	127,945,293 (GRCm39)	critical splice donor site	probably null
R1951:Zranb3	UTSW	1	127,927,136 (GRCm39)	missense	probably damaging	1.00
R1953:Zranb3	UTSW	1	127,927,136 (GRCm39)	missense	probably damaging	1.00
R1988:Zranb3	UTSW	1	127,887,480 (GRCm39)	missense	probably benign
R2011:Zranb3	UTSW	1	128,019,638 (GRCm39)	missense	probably benign	0.00
R3159:Zranb3	UTSW	1	127,900,686 (GRCm39)	missense	probably benign
R4179:Zranb3	UTSW	1	127,888,601 (GRCm39)	missense	possibly damaging	0.88
R4281:Zranb3	UTSW	1	127,891,614 (GRCm39)	missense	possibly damaging	0.69
R4400:Zranb3	UTSW	1	127,884,392 (GRCm39)	missense	possibly damaging	0.87
R5236:Zranb3	UTSW	1	127,968,726 (GRCm39)	missense	probably damaging	1.00
R5330:Zranb3	UTSW	1	127,887,457 (GRCm39)	missense	probably damaging	0.99
R5719:Zranb3	UTSW	1	127,891,613 (GRCm39)	missense	probably benign	0.00
R6125:Zranb3	UTSW	1	127,887,482 (GRCm39)	missense	probably benign
R6220:Zranb3	UTSW	1	127,927,141 (GRCm39)	missense	probably benign	0.44
R6414:Zranb3	UTSW	1	127,968,694 (GRCm39)	missense	probably benign	0.08
R6751:Zranb3	UTSW	1	127,887,556 (GRCm39)	missense	probably benign
R7229:Zranb3	UTSW	1	127,968,630 (GRCm39)	missense	probably benign	0.00
R7419:Zranb3	UTSW	1	127,891,588 (GRCm39)	missense	possibly damaging	0.86
R7537:Zranb3	UTSW	1	127,960,584 (GRCm39)	critical splice donor site	probably null
R7771:Zranb3	UTSW	1	127,960,605 (GRCm39)	missense	probably damaging	1.00
R7980:Zranb3	UTSW	1	128,030,671 (GRCm39)	unclassified	probably benign
R8152:Zranb3	UTSW	1	127,882,732 (GRCm39)	missense	probably damaging	1.00
R8370:Zranb3	UTSW	1	127,895,670 (GRCm39)	missense	probably benign	0.00
R8458:Zranb3	UTSW	1	127,920,647 (GRCm39)	missense	probably damaging	1.00
R8816:Zranb3	UTSW	1	127,964,347 (GRCm39)	missense	possibly damaging	0.95
R8969:Zranb3	UTSW	1	127,888,588 (GRCm39)	missense	possibly damaging	0.80
R9369:Zranb3	UTSW	1	127,887,828 (GRCm39)	missense	probably benign	0.00
R9468:Zranb3	UTSW	1	127,891,496 (GRCm39)	critical splice donor site	probably null
Z1176:Zranb3	UTSW	1	127,964,218 (GRCm39)	missense	probably benign	0.25
Z1176:Zranb3	UTSW	1	127,892,885 (GRCm39)	missense	possibly damaging	0.55

Posted On

2012-12-06