Incidental Mutation 'IGL01768:Olfr859'
ID153984
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr859
Ensembl Gene ENSMUSG00000095448
Gene Nameolfactory receptor 859
SynonymsMOR146-3, GA_x6K02T2PVTD-13548326-13549255, MOR146-10_p
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL01768
Quality Score
Status
Chromosome9
Chromosomal Location19804906-19817626 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 19809160 bp
ZygosityHeterozygous
Amino Acid Change Valine to Methionine at position 281 (V281M)
Ref Sequence ENSEMBL: ENSMUSP00000151076 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086480] [ENSMUST00000212540] [ENSMUST00000217280]
Predicted Effect possibly damaging
Transcript: ENSMUST00000086480
AA Change: V281M

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000083669
Gene: ENSMUSG00000095448
AA Change: V281M

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.2e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2e-7 PFAM
Pfam:7tm_1 41 290 3.9e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000212540
AA Change: V281M

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000217280
AA Change: V281M

PolyPhen 2 Score 0.571 (Sensitivity: 0.88; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931417E11Rik A T 6: 73,468,916 L217M possibly damaging Het
Aifm3 T C 16: 17,506,277 V567A possibly damaging Het
Arnt T C 3: 95,491,016 probably benign Het
C8b G A 4: 104,786,954 E273K probably benign Het
Capn5 C T 7: 98,125,273 R570H probably damaging Het
Ccdc173 A T 2: 69,782,127 probably benign Het
Cdh9 A T 15: 16,778,225 D42V possibly damaging Het
Cdk17 T C 10: 93,208,261 S21P probably damaging Het
Cdkl3 T A 11: 52,025,917 F291I probably damaging Het
Clmn T C 12: 104,781,719 E523G probably damaging Het
Cyp4f14 A T 17: 32,908,002 I318N probably damaging Het
Daam1 T A 12: 71,989,885 F1068L probably benign Het
Ext2 A G 2: 93,791,110 probably benign Het
F5 T A 1: 164,176,345 F236L probably benign Het
Fat2 A G 11: 55,262,568 V3606A probably damaging Het
Gpam G A 19: 55,087,520 T220M probably benign Het
Hyal1 C A 9: 107,579,139 L342I probably damaging Het
Ilvbl C A 10: 78,583,293 P459T possibly damaging Het
Itga5 A G 15: 103,351,570 Y632H probably benign Het
Krt73 T C 15: 101,798,856 D299G probably benign Het
Lcp1 T C 14: 75,224,133 V522A probably benign Het
Lmo3 A G 6: 138,416,497 C53R probably damaging Het
Nsun7 T C 5: 66,278,700 V305A probably benign Het
Olfr1391 G A 11: 49,328,131 C240Y probably damaging Het
Olfr1427 A T 19: 12,099,039 I200N probably damaging Het
Oprm1 T C 10: 6,829,186 S196P probably damaging Het
Ovgp1 T C 3: 105,981,351 probably null Het
Pcdhb20 T C 18: 37,506,715 F765L possibly damaging Het
Ppp4r4 T C 12: 103,581,405 V3A probably benign Het
Ruvbl1 A G 6: 88,497,271 I419V probably benign Het
Scara5 T A 14: 65,689,775 C40* probably null Het
Siglec1 T C 2: 131,074,394 Q1212R probably benign Het
Slc31a1 G A 4: 62,388,036 probably null Het
Sparc G T 11: 55,405,243 N87K probably damaging Het
Tcf12 T C 9: 71,868,996 probably null Het
Timm44 A T 8: 4,266,860 F258I probably benign Het
Tm2d2 G T 8: 25,018,079 V80L possibly damaging Het
Tpr A G 1: 150,444,448 D2249G possibly damaging Het
Trim50 G T 5: 135,363,882 G217V possibly damaging Het
Ugcg T C 4: 59,217,216 probably null Het
Vmn2r107 A T 17: 20,345,606 H61L probably benign Het
Zfp84 A G 7: 29,776,666 H261R probably benign Het
Zswim2 A T 2: 83,917,957 M293K probably benign Het
Other mutations in Olfr859
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00156:Olfr859 APN 9 19808396 missense probably benign 0.09
IGL00897:Olfr859 APN 9 19808621 missense probably damaging 0.97
IGL01132:Olfr859 APN 9 19808654 missense probably damaging 0.97
IGL02302:Olfr859 APN 9 19808685 missense probably damaging 0.97
IGL02377:Olfr859 APN 9 19809047 missense probably damaging 0.99
IGL02972:Olfr859 APN 9 19808942 missense probably damaging 0.97
R0139:Olfr859 UTSW 9 19808869 missense probably damaging 0.99
R0367:Olfr859 UTSW 9 19808543 missense probably damaging 0.99
R0521:Olfr859 UTSW 9 19808860 missense probably benign 0.00
R1196:Olfr859 UTSW 9 19808632 missense probably benign 0.00
R3742:Olfr859 UTSW 9 19808899 missense probably benign 0.44
R5567:Olfr859 UTSW 9 19808378 missense probably damaging 0.99
R6499:Olfr859 UTSW 9 19808551 missense probably benign
R6501:Olfr859 UTSW 9 19808975 missense possibly damaging 0.95
R6560:Olfr859 UTSW 9 19809116 missense probably benign
Posted On2014-02-04