Incidental Mutation 'IGL01828:Vmn1r88'
| ID |
154700 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r88
|
| Ensembl Gene |
ENSMUSG00000095902 |
| Gene Name |
vomeronasal 1 receptor, 88 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.054)
|
| Stock # |
IGL01828
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
12911646-12912596 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 12911662 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 6
(T6I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128946
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171783]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000122190
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171783
AA Change: T6I
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000128946
Gene: ENSMUSG00000095902
AA Change: T6I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
306 |
2e-14 |
PFAM |
|
Pfam:V1R
|
35 |
301 |
1.4e-30 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca5 |
T |
C |
11: 110,178,521 (GRCm39) |
I1151V |
probably benign |
Het |
| Abcc4 |
C |
T |
14: 118,790,691 (GRCm39) |
|
probably benign |
Het |
| Asxl3 |
T |
A |
18: 22,658,615 (GRCm39) |
|
probably benign |
Het |
| Car4 |
C |
A |
11: 84,855,571 (GRCm39) |
Q198K |
probably benign |
Het |
| Ces1a |
T |
C |
8: 93,751,829 (GRCm39) |
H435R |
probably damaging |
Het |
| Chdh |
T |
A |
14: 29,758,565 (GRCm39) |
F503L |
probably damaging |
Het |
| Dennd4a |
C |
T |
9: 64,749,843 (GRCm39) |
R145* |
probably null |
Het |
| Dse |
T |
A |
10: 34,028,772 (GRCm39) |
T773S |
probably damaging |
Het |
| Fbxw11 |
T |
A |
11: 32,670,505 (GRCm39) |
L123H |
probably damaging |
Het |
| Gigyf2 |
A |
G |
1: 87,346,820 (GRCm39) |
D550G |
probably damaging |
Het |
| Gm45844 |
T |
C |
7: 7,234,322 (GRCm39) |
|
probably null |
Het |
| Krcc1 |
T |
A |
6: 71,261,351 (GRCm39) |
Y128N |
probably damaging |
Het |
| Myh8 |
T |
C |
11: 67,194,652 (GRCm39) |
M1621T |
possibly damaging |
Het |
| Notch2 |
T |
A |
3: 97,979,929 (GRCm39) |
C148S |
probably damaging |
Het |
| Plcg2 |
C |
A |
8: 118,316,972 (GRCm39) |
H616Q |
probably damaging |
Het |
| Plec |
T |
C |
15: 76,067,955 (GRCm39) |
E1218G |
probably damaging |
Het |
| Plekhm2 |
T |
C |
4: 141,356,896 (GRCm39) |
E749G |
probably benign |
Het |
| Slco1a6 |
C |
T |
6: 142,042,137 (GRCm39) |
V480M |
probably damaging |
Het |
| Vmn2r14 |
A |
G |
5: 109,372,443 (GRCm39) |
F16L |
possibly damaging |
Het |
| Ywhab |
G |
A |
2: 163,853,694 (GRCm39) |
R57H |
possibly damaging |
Het |
|
| Other mutations in Vmn1r88 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01879:Vmn1r88
|
APN |
7 |
12,912,229 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02028:Vmn1r88
|
APN |
7 |
12,911,719 (GRCm39) |
missense |
probably benign |
|
|
IGL02586:Vmn1r88
|
APN |
7 |
12,911,735 (GRCm39) |
nonsense |
probably null |
|
|
IGL03176:Vmn1r88
|
APN |
7 |
12,911,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4466001:Vmn1r88
|
UTSW |
7 |
12,912,403 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1163:Vmn1r88
|
UTSW |
7 |
12,912,060 (GRCm39) |
missense |
probably benign |
|
|
R1478:Vmn1r88
|
UTSW |
7 |
12,911,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2376:Vmn1r88
|
UTSW |
7 |
12,911,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3624:Vmn1r88
|
UTSW |
7 |
12,911,790 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4543:Vmn1r88
|
UTSW |
7 |
12,911,907 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4593:Vmn1r88
|
UTSW |
7 |
12,911,769 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4721:Vmn1r88
|
UTSW |
7 |
12,912,451 (GRCm39) |
nonsense |
probably null |
|
|
R5927:Vmn1r88
|
UTSW |
7 |
12,912,440 (GRCm39) |
missense |
probably benign |
0.12 |
|
R6411:Vmn1r88
|
UTSW |
7 |
12,911,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6535:Vmn1r88
|
UTSW |
7 |
12,912,112 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6598:Vmn1r88
|
UTSW |
7 |
12,912,150 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6857:Vmn1r88
|
UTSW |
7 |
12,912,258 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9389:Vmn1r88
|
UTSW |
7 |
12,912,546 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9769:Vmn1r88
|
UTSW |
7 |
12,912,280 (GRCm39) |
missense |
probably damaging |
0.97 |
|
| Posted On |
2014-02-04 |
Incidental Mutation