Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02003:Mroh7'

182187

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mroh7

Ensembl Gene

ENSMUSG00000047502

Gene Name

maestro heat-like repeat family member 7

Synonyms

Heatr8, Gm1027, LOC381538

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02003

Quality Score

Status

Chromosome

Chromosomal Location

106537614-106588122 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 106559726 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 734 (T734A)

Ref Sequence

ENSEMBL: ENSMUSP00000102382 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106770]

AlphaFold

A2AVR2

Predicted Effect

probably damaging
Transcript: ENSMUST00000106770
AA Change: T734A

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000102382
Gene: ENSMUSG00000047502
AA Change: T734A

Domain	Start	End	E-Value	Type
low complexity region	39	61	N/A	INTRINSIC
low complexity region	318	332	N/A	INTRINSIC
low complexity region	563	573	N/A	INTRINSIC
SCOP:d1b3ua_	634	1218	6e-9	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134160

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135000

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142954

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145374

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930449E01Rik	A	G	14: 105,736,392 (GRCm39)		noncoding transcript	Het
Adam1b	G	A	5: 121,639,354 (GRCm39)	L564F	probably damaging	Het
Alms1	C	T	6: 85,599,205 (GRCm39)	P1344S	possibly damaging	Het
Cnnm2	G	T	19: 46,856,998 (GRCm39)	G699W	probably damaging	Het
Crybg2	A	G	4: 133,799,767 (GRCm39)	K309R	probably benign	Het
Csnk2a1	C	T	2: 152,118,890 (GRCm39)	R333*	probably null	Het
Eif3m	C	T	2: 104,843,188 (GRCm39)		probably benign	Het
Fgfr2	T	C	7: 129,820,802 (GRCm39)	D244G	probably damaging	Het
H2-Q10	A	G	17: 35,781,338 (GRCm39)	I47V	probably benign	Het
Hmcn2	C	T	2: 31,318,994 (GRCm39)	T3898I	possibly damaging	Het
Isyna1	G	A	8: 71,049,407 (GRCm39)	V440M	possibly damaging	Het
Itpr3	A	G	17: 27,340,449 (GRCm39)	K2654E	probably damaging	Het
Lrrd1	C	T	5: 3,899,857 (GRCm39)	T54I	probably damaging	Het
Lrrk2	G	A	15: 91,615,694 (GRCm39)	V843M	probably damaging	Het
Morc2b	A	T	17: 33,357,298 (GRCm39)	V158D	probably benign	Het
Mylk3	T	C	8: 86,085,727 (GRCm39)	D136G	probably benign	Het
Nos1	T	C	5: 118,043,530 (GRCm39)	S602P	probably damaging	Het
Nsmaf	T	C	4: 6,418,522 (GRCm39)	I428V	probably benign	Het
Nup93	T	G	8: 95,028,737 (GRCm39)	Y323*	probably null	Het
Or5ac21	G	A	16: 59,123,996 (GRCm39)	G161D	probably damaging	Het
Or7g21	A	T	9: 19,032,361 (GRCm39)	M34L	probably benign	Het
Or8b50	C	T	9: 38,518,136 (GRCm39)	A125V	probably damaging	Het
Ppm1m	C	A	9: 106,076,356 (GRCm39)	G13W	probably damaging	Het
Prok1	T	G	3: 107,142,979 (GRCm39)	H75P	probably damaging	Het
Ptprb	A	T	10: 116,203,410 (GRCm39)	I1774F	probably damaging	Het
Rasl10b	A	T	11: 83,308,679 (GRCm39)	E73V	probably damaging	Het
Rhbdl3	A	G	11: 80,228,342 (GRCm39)	T271A	possibly damaging	Het
Serpina3a	A	G	12: 104,082,259 (GRCm39)	M11V	probably benign	Het
Setdb2	T	C	14: 59,650,939 (GRCm39)	E464G	probably damaging	Het
Slc8a1	A	G	17: 81,735,625 (GRCm39)	I749T	possibly damaging	Het
Slco6d1	T	A	1: 98,408,493 (GRCm39)	I463N	probably damaging	Het
Sncb	A	T	13: 54,910,743 (GRCm39)	V51E	probably damaging	Het
Stk32c	A	G	7: 138,768,069 (GRCm39)	S71P	possibly damaging	Het
Tet1	A	G	10: 62,652,179 (GRCm39)	V1613A	possibly damaging	Het
Vmn2r91	T	A	17: 18,327,921 (GRCm39)	I505K	probably benign	Het
Zfp110	A	T	7: 12,583,832 (GRCm39)	K827*	probably null	Het
Zfp438	A	T	18: 5,214,503 (GRCm39)	C152S	probably benign	Het

Other mutations in Mroh7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01722:Mroh7	APN	4	106,560,358 (GRCm39)	missense	probably benign	0.00
IGL01729:Mroh7	APN	4	106,561,402 (GRCm39)	missense	possibly damaging	0.66
IGL01834:Mroh7	APN	4	106,538,071 (GRCm39)	missense	probably benign	0.00
IGL02135:Mroh7	APN	4	106,559,707 (GRCm39)	missense	probably damaging	1.00
IGL02335:Mroh7	APN	4	106,564,979 (GRCm39)	missense	probably damaging	1.00
IGL02532:Mroh7	APN	4	106,577,788 (GRCm39)	missense	probably benign	0.04
IGL02896:Mroh7	APN	4	106,557,013 (GRCm39)	missense	possibly damaging	0.94
IGL03066:Mroh7	APN	4	106,549,595 (GRCm39)	missense	possibly damaging	0.85
IGL03298:Mroh7	APN	4	106,571,288 (GRCm39)	nonsense	probably null
holy	UTSW	4	106,567,152 (GRCm39)	splice site	probably null
moley	UTSW	4	106,551,509 (GRCm39)	splice site	probably null
P0016:Mroh7	UTSW	4	106,565,054 (GRCm39)	critical splice acceptor site	probably null
R0019:Mroh7	UTSW	4	106,578,623 (GRCm39)	missense	probably benign	0.07
R0094:Mroh7	UTSW	4	106,560,381 (GRCm39)	missense	probably damaging	0.98
R0105:Mroh7	UTSW	4	106,568,467 (GRCm39)	missense	possibly damaging	0.49
R0105:Mroh7	UTSW	4	106,568,467 (GRCm39)	missense	possibly damaging	0.49
R0515:Mroh7	UTSW	4	106,548,861 (GRCm39)	missense	probably benign	0.01
R0828:Mroh7	UTSW	4	106,557,073 (GRCm39)	missense	probably damaging	0.99
R0831:Mroh7	UTSW	4	106,537,990 (GRCm39)	missense	possibly damaging	0.92
R1107:Mroh7	UTSW	4	106,564,791 (GRCm39)	splice site	probably null
R1301:Mroh7	UTSW	4	106,577,692 (GRCm39)	missense	probably damaging	0.99
R1456:Mroh7	UTSW	4	106,552,338 (GRCm39)	splice site	probably benign
R1491:Mroh7	UTSW	4	106,560,255 (GRCm39)	missense	probably benign	0.11
R1540:Mroh7	UTSW	4	106,560,273 (GRCm39)	missense	probably benign	0.11
R1560:Mroh7	UTSW	4	106,568,451 (GRCm39)	missense	possibly damaging	0.78
R1645:Mroh7	UTSW	4	106,577,865 (GRCm39)	missense	probably benign	0.19
R1804:Mroh7	UTSW	4	106,551,589 (GRCm39)	missense	possibly damaging	0.76
R2162:Mroh7	UTSW	4	106,557,378 (GRCm39)	missense	probably damaging	0.96
R2265:Mroh7	UTSW	4	106,578,124 (GRCm39)	missense	probably benign	0.01
R2866:Mroh7	UTSW	4	106,548,287 (GRCm39)	missense	probably damaging	1.00
R3716:Mroh7	UTSW	4	106,561,407 (GRCm39)	missense	probably benign	0.25
R3718:Mroh7	UTSW	4	106,561,407 (GRCm39)	missense	probably benign	0.25
R4530:Mroh7	UTSW	4	106,577,634 (GRCm39)	missense	possibly damaging	0.71
R4661:Mroh7	UTSW	4	106,548,710 (GRCm39)	critical splice donor site	probably null
R4706:Mroh7	UTSW	4	106,548,821 (GRCm39)	missense	possibly damaging	0.86
R4910:Mroh7	UTSW	4	106,567,152 (GRCm39)	splice site	probably null
R4965:Mroh7	UTSW	4	106,548,184 (GRCm39)	missense	possibly damaging	0.77
R4969:Mroh7	UTSW	4	106,538,070 (GRCm39)	missense	probably benign
R4971:Mroh7	UTSW	4	106,548,749 (GRCm39)	missense	probably benign	0.04
R5083:Mroh7	UTSW	4	106,547,515 (GRCm39)	missense	probably benign	0.03
R5207:Mroh7	UTSW	4	106,578,583 (GRCm39)	missense	probably damaging	0.97
R5364:Mroh7	UTSW	4	106,548,840 (GRCm39)	missense	probably benign	0.10
R5392:Mroh7	UTSW	4	106,568,448 (GRCm39)	critical splice donor site	probably null
R5630:Mroh7	UTSW	4	106,577,764 (GRCm39)	missense	possibly damaging	0.71
R5691:Mroh7	UTSW	4	106,559,815 (GRCm39)	missense	probably damaging	0.96
R5703:Mroh7	UTSW	4	106,565,757 (GRCm39)	missense	possibly damaging	0.77
R5707:Mroh7	UTSW	4	106,539,082 (GRCm39)	missense	possibly damaging	0.73
R5919:Mroh7	UTSW	4	106,551,509 (GRCm39)	splice site	probably null
R5979:Mroh7	UTSW	4	106,578,123 (GRCm39)	missense	probably benign	0.00
R6479:Mroh7	UTSW	4	106,560,385 (GRCm39)	missense	possibly damaging	0.75
R6520:Mroh7	UTSW	4	106,578,460 (GRCm39)	missense	probably benign	0.00
R6657:Mroh7	UTSW	4	106,559,697 (GRCm39)	nonsense	probably null
R6732:Mroh7	UTSW	4	106,537,910 (GRCm39)	frame shift	probably null
R6817:Mroh7	UTSW	4	106,571,312 (GRCm39)	missense	probably benign	0.00
R6980:Mroh7	UTSW	4	106,557,434 (GRCm39)	missense	probably benign	0.05
R7062:Mroh7	UTSW	4	106,541,177 (GRCm39)	missense	probably damaging	1.00
R7116:Mroh7	UTSW	4	106,568,517 (GRCm39)	missense	probably benign	0.07
R7134:Mroh7	UTSW	4	106,577,791 (GRCm39)	missense	probably damaging	0.99
R7169:Mroh7	UTSW	4	106,548,836 (GRCm39)	missense	probably damaging	0.99
R7419:Mroh7	UTSW	4	106,541,115 (GRCm39)	missense	probably benign
R7516:Mroh7	UTSW	4	106,548,316 (GRCm39)	missense	probably benign	0.00
R7525:Mroh7	UTSW	4	106,566,899 (GRCm39)	missense	probably benign	0.22
R7540:Mroh7	UTSW	4	106,577,595 (GRCm39)	missense	possibly damaging	0.85
R7849:Mroh7	UTSW	4	106,578,287 (GRCm39)	missense	probably benign
R7920:Mroh7	UTSW	4	106,564,773 (GRCm39)	missense	probably benign
R7998:Mroh7	UTSW	4	106,568,478 (GRCm39)	missense	probably benign	0.02
R8026:Mroh7	UTSW	4	106,578,634 (GRCm39)	missense	probably benign	0.01
R8122:Mroh7	UTSW	4	106,559,726 (GRCm39)	missense	probably damaging	0.96
R8249:Mroh7	UTSW	4	106,578,409 (GRCm39)	missense	probably benign	0.00
R9188:Mroh7	UTSW	4	106,566,789 (GRCm39)	missense	probably benign	0.01

Posted On

2014-05-07