Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03066:Mroh7'

409697

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mroh7

Ensembl Gene

ENSMUSG00000047502

Gene Name

maestro heat-like repeat family member 7

Synonyms

Heatr8, Gm1027, LOC381538

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03066

Quality Score

Status

Chromosome

Chromosomal Location

106537614-106588122 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 106549595 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 950 (V950A)

Ref Sequence

ENSEMBL: ENSMUSP00000102382 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106770]

AlphaFold

A2AVR2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000106770
AA Change: V950A

PolyPhen 2 Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000102382
Gene: ENSMUSG00000047502
AA Change: V950A

Domain	Start	End	E-Value	Type
low complexity region	39	61	N/A	INTRINSIC
low complexity region	318	332	N/A	INTRINSIC
low complexity region	563	573	N/A	INTRINSIC
SCOP:d1b3ua_	634	1218	6e-9	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134160

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135000

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142954

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145374

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Brd4	A	C	17: 32,418,062 (GRCm39)		probably benign	Het
Cd209d	C	A	8: 3,928,437 (GRCm39)		probably null	Het
Cela2a	T	A	4: 141,548,765 (GRCm39)	I124F	probably damaging	Het
Cemip2	G	A	19: 21,801,207 (GRCm39)	D775N	possibly damaging	Het
Cnot2	A	T	10: 116,335,262 (GRCm39)	N245K	probably benign	Het
Cpt2	A	G	4: 107,765,183 (GRCm39)	F148L	probably benign	Het
Ctsj	A	C	13: 61,152,302 (GRCm39)	H21Q	possibly damaging	Het
Cul4a	A	G	8: 13,183,776 (GRCm39)	N388S	probably benign	Het
Dnah12	A	G	14: 26,418,553 (GRCm39)	D147G	probably benign	Het
Dnhd1	A	G	7: 105,369,089 (GRCm39)	T4287A	probably damaging	Het
Dock10	C	A	1: 80,562,758 (GRCm39)	C534F	probably benign	Het
Efcab14	A	G	4: 115,596,001 (GRCm39)	E49G	probably benign	Het
Fancm	G	T	12: 65,171,888 (GRCm39)	E86*	probably null	Het
Galnt17	A	T	5: 130,929,486 (GRCm39)	S440R	probably benign	Het
Hectd4	T	A	5: 121,503,116 (GRCm39)	Y4362N	possibly damaging	Het
Lctl	T	G	9: 64,025,017 (GRCm39)	M1R	probably null	Het
Llgl1	A	G	11: 60,596,860 (GRCm39)	T154A	possibly damaging	Het
Mink1	G	T	11: 70,499,715 (GRCm39)	V750F	probably benign	Het
Myg1	G	A	15: 102,242,801 (GRCm39)		probably benign	Het
Or4x11	A	T	2: 89,867,778 (GRCm39)	I172F	probably damaging	Het
Or6b2b	T	A	1: 92,419,305 (GRCm39)	R57S	probably damaging	Het
Or7d10	A	G	9: 19,831,667 (GRCm39)	H54R	probably benign	Het
Pask	A	T	1: 93,258,588 (GRCm39)	S253R	probably benign	Het
Pkd1	C	A	17: 24,805,208 (GRCm39)	H3253Q	probably damaging	Het
Pkd1l2	G	A	8: 117,792,484 (GRCm39)	T436I	probably benign	Het
Rapgef4	A	G	2: 71,971,523 (GRCm39)		probably benign	Het
Rnf169	G	T	7: 99,574,760 (GRCm39)	R612S	possibly damaging	Het
Sclt1	A	T	3: 41,672,278 (GRCm39)	D104E	probably benign	Het
Shh	G	T	5: 28,666,369 (GRCm39)	D172E	probably damaging	Het
Sil1	G	T	18: 35,402,259 (GRCm39)		probably benign	Het
Slc19a3	A	G	1: 82,992,557 (GRCm39)	I388T	probably damaging	Het
Spink5	A	G	18: 44,149,457 (GRCm39)	Y946C	probably damaging	Het
Sulf1	A	T	1: 12,878,168 (GRCm39)	I219F	probably damaging	Het
Tcf3	T	C	10: 80,248,879 (GRCm39)	D529G	probably damaging	Het
Txnip	G	A	3: 96,466,934 (GRCm39)	E203K	probably damaging	Het
Ubc	G	T	5: 125,465,327 (GRCm39)		probably benign	Het
Ubxn4	A	T	1: 128,188,591 (GRCm39)		probably null	Het
Usp16	T	C	16: 87,268,721 (GRCm39)	V284A	probably damaging	Het
Vmn2r6	T	A	3: 64,472,574 (GRCm39)	N49I	probably damaging	Het
Ythdf1	A	T	2: 180,553,339 (GRCm39)	I292N	probably damaging	Het
Zfp128	A	G	7: 12,624,044 (GRCm39)	I137M	probably benign	Het

Other mutations in Mroh7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01722:Mroh7	APN	4	106,560,358 (GRCm39)	missense	probably benign	0.00
IGL01729:Mroh7	APN	4	106,561,402 (GRCm39)	missense	possibly damaging	0.66
IGL01834:Mroh7	APN	4	106,538,071 (GRCm39)	missense	probably benign	0.00
IGL02003:Mroh7	APN	4	106,559,726 (GRCm39)	missense	probably damaging	0.96
IGL02135:Mroh7	APN	4	106,559,707 (GRCm39)	missense	probably damaging	1.00
IGL02335:Mroh7	APN	4	106,564,979 (GRCm39)	missense	probably damaging	1.00
IGL02532:Mroh7	APN	4	106,577,788 (GRCm39)	missense	probably benign	0.04
IGL02896:Mroh7	APN	4	106,557,013 (GRCm39)	missense	possibly damaging	0.94
IGL03298:Mroh7	APN	4	106,571,288 (GRCm39)	nonsense	probably null
holy	UTSW	4	106,567,152 (GRCm39)	splice site	probably null
moley	UTSW	4	106,551,509 (GRCm39)	splice site	probably null
P0016:Mroh7	UTSW	4	106,565,054 (GRCm39)	critical splice acceptor site	probably null
R0019:Mroh7	UTSW	4	106,578,623 (GRCm39)	missense	probably benign	0.07
R0094:Mroh7	UTSW	4	106,560,381 (GRCm39)	missense	probably damaging	0.98
R0105:Mroh7	UTSW	4	106,568,467 (GRCm39)	missense	possibly damaging	0.49
R0105:Mroh7	UTSW	4	106,568,467 (GRCm39)	missense	possibly damaging	0.49
R0515:Mroh7	UTSW	4	106,548,861 (GRCm39)	missense	probably benign	0.01
R0828:Mroh7	UTSW	4	106,557,073 (GRCm39)	missense	probably damaging	0.99
R0831:Mroh7	UTSW	4	106,537,990 (GRCm39)	missense	possibly damaging	0.92
R1107:Mroh7	UTSW	4	106,564,791 (GRCm39)	splice site	probably null
R1301:Mroh7	UTSW	4	106,577,692 (GRCm39)	missense	probably damaging	0.99
R1456:Mroh7	UTSW	4	106,552,338 (GRCm39)	splice site	probably benign
R1491:Mroh7	UTSW	4	106,560,255 (GRCm39)	missense	probably benign	0.11
R1540:Mroh7	UTSW	4	106,560,273 (GRCm39)	missense	probably benign	0.11
R1560:Mroh7	UTSW	4	106,568,451 (GRCm39)	missense	possibly damaging	0.78
R1645:Mroh7	UTSW	4	106,577,865 (GRCm39)	missense	probably benign	0.19
R1804:Mroh7	UTSW	4	106,551,589 (GRCm39)	missense	possibly damaging	0.76
R2162:Mroh7	UTSW	4	106,557,378 (GRCm39)	missense	probably damaging	0.96
R2265:Mroh7	UTSW	4	106,578,124 (GRCm39)	missense	probably benign	0.01
R2866:Mroh7	UTSW	4	106,548,287 (GRCm39)	missense	probably damaging	1.00
R3716:Mroh7	UTSW	4	106,561,407 (GRCm39)	missense	probably benign	0.25
R3718:Mroh7	UTSW	4	106,561,407 (GRCm39)	missense	probably benign	0.25
R4530:Mroh7	UTSW	4	106,577,634 (GRCm39)	missense	possibly damaging	0.71
R4661:Mroh7	UTSW	4	106,548,710 (GRCm39)	critical splice donor site	probably null
R4706:Mroh7	UTSW	4	106,548,821 (GRCm39)	missense	possibly damaging	0.86
R4910:Mroh7	UTSW	4	106,567,152 (GRCm39)	splice site	probably null
R4965:Mroh7	UTSW	4	106,548,184 (GRCm39)	missense	possibly damaging	0.77
R4969:Mroh7	UTSW	4	106,538,070 (GRCm39)	missense	probably benign
R4971:Mroh7	UTSW	4	106,548,749 (GRCm39)	missense	probably benign	0.04
R5083:Mroh7	UTSW	4	106,547,515 (GRCm39)	missense	probably benign	0.03
R5207:Mroh7	UTSW	4	106,578,583 (GRCm39)	missense	probably damaging	0.97
R5364:Mroh7	UTSW	4	106,548,840 (GRCm39)	missense	probably benign	0.10
R5392:Mroh7	UTSW	4	106,568,448 (GRCm39)	critical splice donor site	probably null
R5630:Mroh7	UTSW	4	106,577,764 (GRCm39)	missense	possibly damaging	0.71
R5691:Mroh7	UTSW	4	106,559,815 (GRCm39)	missense	probably damaging	0.96
R5703:Mroh7	UTSW	4	106,565,757 (GRCm39)	missense	possibly damaging	0.77
R5707:Mroh7	UTSW	4	106,539,082 (GRCm39)	missense	possibly damaging	0.73
R5919:Mroh7	UTSW	4	106,551,509 (GRCm39)	splice site	probably null
R5979:Mroh7	UTSW	4	106,578,123 (GRCm39)	missense	probably benign	0.00
R6479:Mroh7	UTSW	4	106,560,385 (GRCm39)	missense	possibly damaging	0.75
R6520:Mroh7	UTSW	4	106,578,460 (GRCm39)	missense	probably benign	0.00
R6657:Mroh7	UTSW	4	106,559,697 (GRCm39)	nonsense	probably null
R6732:Mroh7	UTSW	4	106,537,910 (GRCm39)	frame shift	probably null
R6817:Mroh7	UTSW	4	106,571,312 (GRCm39)	missense	probably benign	0.00
R6980:Mroh7	UTSW	4	106,557,434 (GRCm39)	missense	probably benign	0.05
R7062:Mroh7	UTSW	4	106,541,177 (GRCm39)	missense	probably damaging	1.00
R7116:Mroh7	UTSW	4	106,568,517 (GRCm39)	missense	probably benign	0.07
R7134:Mroh7	UTSW	4	106,577,791 (GRCm39)	missense	probably damaging	0.99
R7169:Mroh7	UTSW	4	106,548,836 (GRCm39)	missense	probably damaging	0.99
R7419:Mroh7	UTSW	4	106,541,115 (GRCm39)	missense	probably benign
R7516:Mroh7	UTSW	4	106,548,316 (GRCm39)	missense	probably benign	0.00
R7525:Mroh7	UTSW	4	106,566,899 (GRCm39)	missense	probably benign	0.22
R7540:Mroh7	UTSW	4	106,577,595 (GRCm39)	missense	possibly damaging	0.85
R7849:Mroh7	UTSW	4	106,578,287 (GRCm39)	missense	probably benign
R7920:Mroh7	UTSW	4	106,564,773 (GRCm39)	missense	probably benign
R7998:Mroh7	UTSW	4	106,568,478 (GRCm39)	missense	probably benign	0.02
R8026:Mroh7	UTSW	4	106,578,634 (GRCm39)	missense	probably benign	0.01
R8122:Mroh7	UTSW	4	106,559,726 (GRCm39)	missense	probably damaging	0.96
R8249:Mroh7	UTSW	4	106,578,409 (GRCm39)	missense	probably benign	0.00
R9188:Mroh7	UTSW	4	106,566,789 (GRCm39)	missense	probably benign	0.01

Posted On

2016-08-02