Incidental Mutation 'IGL01996:Fbxw24'
ID 182891
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw24
Ensembl Gene ENSMUSG00000062275
Gene Name F-box and WD-40 domain protein 24
Synonyms Gm5162
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # IGL01996
Quality Score
Status
Chromosome 9
Chromosomal Location 109430184-109455125 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 109434440 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 387 (R387G)
Ref Sequence ENSEMBL: ENSMUSP00000073617 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073962]
AlphaFold E9PXM9
Predicted Effect possibly damaging
Transcript: ENSMUST00000073962
AA Change: R387G

PolyPhen 2 Score 0.841 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000073617
Gene: ENSMUSG00000062275
AA Change: R387G

DomainStartEndE-ValueType
FBOX 8 45 3.25e-4 SMART
SCOP:d1gxra_ 87 227 8e-7 SMART
Blast:WD40 137 176 1e-6 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110009E18Rik T C 1: 120,078,430 (GRCm39) V29A possibly damaging Het
Adarb1 A G 10: 77,158,051 (GRCm39) L132P probably damaging Het
Afg3l1 T G 8: 124,228,633 (GRCm39) M733R probably damaging Het
Aox1 C T 1: 58,121,225 (GRCm39) R899C probably benign Het
Arhgap44 T A 11: 64,896,322 (GRCm39) probably benign Het
Asns T C 6: 7,682,378 (GRCm39) D189G possibly damaging Het
Brap A G 5: 121,816,910 (GRCm39) probably benign Het
Ccdc138 T A 10: 58,397,852 (GRCm39) L564H probably damaging Het
Ccdc167 A G 17: 29,924,461 (GRCm39) probably null Het
Ccdc178 A G 18: 22,230,813 (GRCm39) Y353H probably damaging Het
Clca3b A T 3: 144,554,924 (GRCm39) S41R probably benign Het
Dpep3 T C 8: 106,701,358 (GRCm39) N397S probably damaging Het
Eif1 T C 11: 100,211,826 (GRCm39) I83T probably benign Het
Enah A T 1: 181,784,070 (GRCm39) W80R unknown Het
F2rl1 C T 13: 95,650,432 (GRCm39) C150Y probably damaging Het
Fsd1l A G 4: 53,647,760 (GRCm39) T68A probably benign Het
Greb1 T C 12: 16,740,846 (GRCm39) K1412R possibly damaging Het
Grin2b T C 6: 135,709,584 (GRCm39) S1321G probably damaging Het
H4c11 G A 13: 21,919,308 (GRCm39) G15S unknown Het
Itgb7 C T 15: 102,126,412 (GRCm39) G508D probably damaging Het
Kcnq3 A G 15: 65,895,545 (GRCm39) I333T probably damaging Het
Knl1 A G 2: 118,934,542 (GRCm39) D2115G probably damaging Het
Lmtk3 G A 7: 45,442,871 (GRCm39) probably null Het
Lrpprc A G 17: 85,080,698 (GRCm39) Y176H probably benign Het
Mier1 T C 4: 102,984,473 (GRCm39) S22P possibly damaging Het
Mme A T 3: 63,250,970 (GRCm39) N337I probably benign Het
Mthfd1 A G 12: 76,350,679 (GRCm39) Y687C probably damaging Het
Nrp2 T C 1: 62,788,419 (GRCm39) M373T probably damaging Het
Nudcd1 A T 15: 44,269,357 (GRCm39) F101Y probably benign Het
Nup133 T A 8: 124,673,334 (GRCm39) I66L probably benign Het
Or10j7 T C 1: 173,011,294 (GRCm39) T236A probably benign Het
Or11j4 T G 14: 50,631,116 (GRCm39) M301R probably damaging Het
Or1e19 T A 11: 73,316,794 (GRCm39) N5I probably damaging Het
Osbpl5 A G 7: 143,261,081 (GRCm39) probably null Het
Paqr8 T C 1: 21,005,628 (GRCm39) F261L probably damaging Het
Plxna2 A G 1: 194,482,084 (GRCm39) E1452G probably damaging Het
Polh T C 17: 46,483,927 (GRCm39) D446G probably benign Het
Psg19 A T 7: 18,523,986 (GRCm39) M353K possibly damaging Het
Sap25 T C 5: 137,640,080 (GRCm39) probably null Het
Sap30l C T 11: 57,700,777 (GRCm39) R144* probably null Het
Sema6b C T 17: 56,438,157 (GRCm39) V144M probably damaging Het
Sfmbt2 T C 2: 10,444,837 (GRCm39) Y228H probably benign Het
Shank2 A G 7: 143,965,230 (GRCm39) D946G probably damaging Het
Slc11a1 T A 1: 74,415,965 (GRCm39) L52Q possibly damaging Het
Sptlc3 T C 2: 139,423,424 (GRCm39) probably benign Het
Tgfb1i1 T C 7: 127,848,464 (GRCm39) probably benign Het
Tifa T C 3: 127,590,229 (GRCm39) probably benign Het
Tomm40l C T 1: 171,047,224 (GRCm39) V265M possibly damaging Het
Trim45 C A 3: 100,835,425 (GRCm39) Y469* probably null Het
Ttc21a G T 9: 119,787,182 (GRCm39) A730S probably damaging Het
Vmn1r18 A T 6: 57,367,001 (GRCm39) D184E possibly damaging Het
Vmn2r120 A T 17: 57,832,222 (GRCm39) I189N possibly damaging Het
Other mutations in Fbxw24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01093:Fbxw24 APN 9 109,434,041 (GRCm39) missense probably benign 0.00
IGL01373:Fbxw24 APN 9 109,452,701 (GRCm39) missense probably damaging 0.98
IGL02179:Fbxw24 APN 9 109,438,973 (GRCm39) nonsense probably null
IGL02718:Fbxw24 APN 9 109,453,858 (GRCm39) missense possibly damaging 0.55
IGL02936:Fbxw24 APN 9 109,454,026 (GRCm39) splice site probably null
IGL03010:Fbxw24 APN 9 109,452,678 (GRCm39) missense probably benign 0.07
IGL03350:Fbxw24 APN 9 109,436,081 (GRCm39) missense probably damaging 1.00
IGL03402:Fbxw24 APN 9 109,430,316 (GRCm39) missense probably damaging 1.00
R0140:Fbxw24 UTSW 9 109,434,482 (GRCm39) missense possibly damaging 0.73
R0718:Fbxw24 UTSW 9 109,452,577 (GRCm39) splice site probably benign
R1166:Fbxw24 UTSW 9 109,436,066 (GRCm39) missense probably benign 0.00
R1550:Fbxw24 UTSW 9 109,436,112 (GRCm39) missense probably benign 0.00
R1950:Fbxw24 UTSW 9 109,434,481 (GRCm39) missense probably benign 0.02
R1986:Fbxw24 UTSW 9 109,436,124 (GRCm39) missense probably damaging 0.97
R2244:Fbxw24 UTSW 9 109,434,117 (GRCm39) missense possibly damaging 0.66
R3683:Fbxw24 UTSW 9 109,437,110 (GRCm39) missense possibly damaging 0.51
R4324:Fbxw24 UTSW 9 109,434,013 (GRCm39) critical splice donor site probably null
R4387:Fbxw24 UTSW 9 109,439,053 (GRCm39) missense probably damaging 1.00
R4409:Fbxw24 UTSW 9 109,437,256 (GRCm39) missense probably damaging 1.00
R4410:Fbxw24 UTSW 9 109,437,256 (GRCm39) missense probably damaging 1.00
R4803:Fbxw24 UTSW 9 109,453,910 (GRCm39) missense probably benign 0.02
R5571:Fbxw24 UTSW 9 109,436,066 (GRCm39) missense probably benign 0.00
R6042:Fbxw24 UTSW 9 109,436,079 (GRCm39) missense probably benign 0.09
R6523:Fbxw24 UTSW 9 109,434,048 (GRCm39) nonsense probably null
R6799:Fbxw24 UTSW 9 109,453,998 (GRCm39) missense probably damaging 1.00
R7122:Fbxw24 UTSW 9 109,430,328 (GRCm39) missense probably benign 0.03
R7239:Fbxw24 UTSW 9 109,434,598 (GRCm39) missense possibly damaging 0.71
R7405:Fbxw24 UTSW 9 109,436,136 (GRCm39) missense possibly damaging 0.46
R7705:Fbxw24 UTSW 9 109,437,516 (GRCm39) splice site probably null
R8536:Fbxw24 UTSW 9 109,452,599 (GRCm39) missense probably damaging 1.00
R8873:Fbxw24 UTSW 9 109,453,996 (GRCm39) missense probably damaging 1.00
R9332:Fbxw24 UTSW 9 109,452,681 (GRCm39) missense probably damaging 1.00
R9430:Fbxw24 UTSW 9 109,439,038 (GRCm39) missense probably damaging 0.99
Posted On 2014-05-07