Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03350:Fbxw24'

419649

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw24

Ensembl Gene

ENSMUSG00000062275

Gene Name

F-box and WD-40 domain protein 24

Synonyms

Gm5162

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL03350

Quality Score

Status

Chromosome

Chromosomal Location

109430184-109455125 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 109436081 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 317 (D317G)

Ref Sequence

ENSEMBL: ENSMUSP00000073617 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073962]

AlphaFold

E9PXM9

Predicted Effect

probably damaging
Transcript: ENSMUST00000073962
AA Change: D317G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000073617
Gene: ENSMUSG00000062275
AA Change: D317G

Domain	Start	End	E-Value	Type
FBOX	8	45	3.25e-4	SMART
SCOP:d1gxra_	87	227	8e-7	SMART
Blast:WD40	137	176	1e-6	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam26a	A	T	8: 44,022,589 (GRCm39)	Y300*	probably null	Het
Adgre1	T	A	17: 57,708,908 (GRCm39)	V33E	probably benign	Het
AI987944	A	G	7: 41,042,661 (GRCm39)		probably benign	Het
Atp4a	T	C	7: 30,420,292 (GRCm39)	L813P	probably damaging	Het
Blmh	A	G	11: 76,862,774 (GRCm39)	N396D	probably damaging	Het
Brat1	T	C	5: 140,691,750 (GRCm39)	L9P	probably damaging	Het
Ccdc171	T	C	4: 83,599,615 (GRCm39)	I810T	possibly damaging	Het
Clec2m	C	A	6: 129,307,986 (GRCm39)	V28L	probably benign	Het
Cyp2a22	T	C	7: 26,634,279 (GRCm39)	T292A	possibly damaging	Het
Ecm2	C	T	13: 49,674,420 (GRCm39)	T280I	probably benign	Het
Fa2h	C	T	8: 112,075,928 (GRCm39)	V232I	probably benign	Het
Flt4	C	A	11: 49,525,620 (GRCm39)	S722*	probably null	Het
Fryl	T	C	5: 73,290,649 (GRCm39)	Q85R	probably damaging	Het
Gm3239	A	G	14: 15,882,083 (GRCm39)	R188G	possibly damaging	Het
Hspa13	A	T	16: 75,554,717 (GRCm39)	S456R	probably damaging	Het
Htr1b	T	C	9: 81,514,175 (GRCm39)	Y144C	probably damaging	Het
Hydin	A	G	8: 111,038,856 (GRCm39)	H198R	possibly damaging	Het
Krt78	A	T	15: 101,854,952 (GRCm39)	M953K	probably benign	Het
Lgr5	G	T	10: 115,307,893 (GRCm39)	T255K	probably damaging	Het
Lrp2	T	A	2: 69,268,797 (GRCm39)	D4162V	probably damaging	Het
Map3k2	A	G	18: 32,345,201 (GRCm39)	D342G	probably damaging	Het
Miip	A	G	4: 147,946,979 (GRCm39)	V258A	probably benign	Het
Muc6	T	C	7: 141,238,324 (GRCm39)	H52R	probably damaging	Het
Nfs1	T	C	2: 155,969,660 (GRCm39)	E329G	probably benign	Het
Npsr1	T	C	9: 24,009,605 (GRCm39)	V37A	probably benign	Het
Or1ak2	T	C	2: 36,827,595 (GRCm39)	Y155H	probably damaging	Het
Or1e17	A	T	11: 73,831,664 (GRCm39)	L197F	probably damaging	Het
Or5aq1b	A	C	2: 86,901,904 (GRCm39)	D191E	probably damaging	Het
Pex16	T	A	2: 92,207,842 (GRCm39)	M98K	probably damaging	Het
Pla2r1	C	T	2: 60,285,517 (GRCm39)	C699Y	probably damaging	Het
Plcd4	A	T	1: 74,588,460 (GRCm39)	D103V	probably damaging	Het
Pnpla1	A	G	17: 29,095,966 (GRCm39)	D129G	probably damaging	Het
Rad23a	T	C	8: 85,564,108 (GRCm39)	E265G	possibly damaging	Het
Rbm11	C	T	16: 75,397,696 (GRCm39)	P209S	probably benign	Het
Ribc2	T	A	15: 85,019,703 (GRCm39)	W162R	probably damaging	Het
Rnf4	A	G	5: 34,504,204 (GRCm39)	E32G	possibly damaging	Het
Rpe65	A	T	3: 159,320,154 (GRCm39)	S269C	possibly damaging	Het
Slc7a14	T	A	3: 31,291,558 (GRCm39)	Y240F	probably benign	Het
Sorbs2	C	T	8: 46,258,844 (GRCm39)	P1047L	probably damaging	Het
Ttn	T	C	2: 76,580,166 (GRCm39)	I23576V	probably damaging	Het
Usp24	T	G	4: 106,228,276 (GRCm39)	Y780*	probably null	Het
Wee2	T	C	6: 40,426,665 (GRCm39)	S145P	probably damaging	Het
Zcchc7	A	G	4: 44,931,188 (GRCm39)	T126A	probably benign	Het
Zpld1	A	G	16: 55,061,692 (GRCm39)		probably benign	Het
Zup1	G	A	10: 33,804,107 (GRCm39)	R456C	probably benign	Het

Other mutations in Fbxw24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01093:Fbxw24	APN	9	109,434,041 (GRCm39)	missense	probably benign	0.00
IGL01373:Fbxw24	APN	9	109,452,701 (GRCm39)	missense	probably damaging	0.98
IGL01996:Fbxw24	APN	9	109,434,440 (GRCm39)	missense	possibly damaging	0.84
IGL02179:Fbxw24	APN	9	109,438,973 (GRCm39)	nonsense	probably null
IGL02718:Fbxw24	APN	9	109,453,858 (GRCm39)	missense	possibly damaging	0.55
IGL02936:Fbxw24	APN	9	109,454,026 (GRCm39)	splice site	probably null
IGL03010:Fbxw24	APN	9	109,452,678 (GRCm39)	missense	probably benign	0.07
IGL03402:Fbxw24	APN	9	109,430,316 (GRCm39)	missense	probably damaging	1.00
R0140:Fbxw24	UTSW	9	109,434,482 (GRCm39)	missense	possibly damaging	0.73
R0718:Fbxw24	UTSW	9	109,452,577 (GRCm39)	splice site	probably benign
R1166:Fbxw24	UTSW	9	109,436,066 (GRCm39)	missense	probably benign	0.00
R1550:Fbxw24	UTSW	9	109,436,112 (GRCm39)	missense	probably benign	0.00
R1950:Fbxw24	UTSW	9	109,434,481 (GRCm39)	missense	probably benign	0.02
R1986:Fbxw24	UTSW	9	109,436,124 (GRCm39)	missense	probably damaging	0.97
R2244:Fbxw24	UTSW	9	109,434,117 (GRCm39)	missense	possibly damaging	0.66
R3683:Fbxw24	UTSW	9	109,437,110 (GRCm39)	missense	possibly damaging	0.51
R4324:Fbxw24	UTSW	9	109,434,013 (GRCm39)	critical splice donor site	probably null
R4387:Fbxw24	UTSW	9	109,439,053 (GRCm39)	missense	probably damaging	1.00
R4409:Fbxw24	UTSW	9	109,437,256 (GRCm39)	missense	probably damaging	1.00
R4410:Fbxw24	UTSW	9	109,437,256 (GRCm39)	missense	probably damaging	1.00
R4803:Fbxw24	UTSW	9	109,453,910 (GRCm39)	missense	probably benign	0.02
R5571:Fbxw24	UTSW	9	109,436,066 (GRCm39)	missense	probably benign	0.00
R6042:Fbxw24	UTSW	9	109,436,079 (GRCm39)	missense	probably benign	0.09
R6523:Fbxw24	UTSW	9	109,434,048 (GRCm39)	nonsense	probably null
R6799:Fbxw24	UTSW	9	109,453,998 (GRCm39)	missense	probably damaging	1.00
R7122:Fbxw24	UTSW	9	109,430,328 (GRCm39)	missense	probably benign	0.03
R7239:Fbxw24	UTSW	9	109,434,598 (GRCm39)	missense	possibly damaging	0.71
R7405:Fbxw24	UTSW	9	109,436,136 (GRCm39)	missense	possibly damaging	0.46
R7705:Fbxw24	UTSW	9	109,437,516 (GRCm39)	splice site	probably null
R8536:Fbxw24	UTSW	9	109,452,599 (GRCm39)	missense	probably damaging	1.00
R8873:Fbxw24	UTSW	9	109,453,996 (GRCm39)	missense	probably damaging	1.00
R9332:Fbxw24	UTSW	9	109,452,681 (GRCm39)	missense	probably damaging	1.00
R9430:Fbxw24	UTSW	9	109,439,038 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02