Incidental Mutation 'R1705:Or2b6'
ID 190034
Institutional Source Beutler Lab
Gene Symbol Or2b6
Ensembl Gene ENSMUSG00000036658
Gene Name olfactory receptor family 2 subfamily B member 6
Synonyms GA_x6K02T2QHY8-11597382-11598323, MOR256-11, Olfr11
MMRRC Submission 039738-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.350) question?
Stock # R1705 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 21822750-21823691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 21823331 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Tyrosine at position 121 (D121Y)
Ref Sequence ENSEMBL: ENSMUSP00000146091 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043081] [ENSMUST00000205631]
AlphaFold Q60890
Predicted Effect probably damaging
Transcript: ENSMUST00000043081
AA Change: D121Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000043099
Gene: ENSMUSG00000036658
AA Change: D121Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 311 4.9e-51 PFAM
Pfam:7tm_1 41 290 7.3e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205631
AA Change: D121Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.7913 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.3%
Validation Efficiency 90% (43/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap8l C T 17: 32,551,457 (GRCm39) R511H probably damaging Het
Apaf1 A G 10: 90,903,133 (GRCm39) probably benign Het
C1ql2 A G 1: 120,270,271 (GRCm39) T278A probably damaging Het
Card14 A G 11: 119,229,232 (GRCm39) H714R possibly damaging Het
Catsperd T C 17: 56,940,521 (GRCm39) F69S probably damaging Het
Cep250 A G 2: 155,805,706 (GRCm39) E105G probably damaging Het
Coil A G 11: 88,864,962 (GRCm39) Y63C probably damaging Het
Cox14 A G 15: 99,625,559 (GRCm39) probably null Het
Defa24 T C 8: 22,224,617 (GRCm39) I22T probably damaging Het
F5 T C 1: 164,045,059 (GRCm39) Y2116H possibly damaging Het
Faf1 C T 4: 109,534,199 (GRCm39) probably benign Het
Hectd4 A G 5: 121,436,167 (GRCm39) S1026G probably benign Het
Hgf A T 5: 16,820,800 (GRCm39) H649L probably benign Het
Hmces T C 6: 87,910,283 (GRCm39) V231A probably damaging Het
Kcnh4 A G 11: 100,632,598 (GRCm39) V963A probably benign Het
Ltbp1 T C 17: 75,692,196 (GRCm39) probably null Het
Meox2 G A 12: 37,217,493 (GRCm39) probably benign Het
Mis18bp1 A C 12: 65,196,113 (GRCm39) S550R probably benign Het
Nap1l4 A T 7: 143,095,497 (GRCm39) M1K probably null Het
Nav1 G T 1: 135,512,337 (GRCm39) T241N probably damaging Het
Nbeal2 A G 9: 110,454,264 (GRCm39) W2694R probably damaging Het
Or11g2 A T 14: 50,856,579 (GRCm39) H300L probably benign Het
Or4c52 A T 2: 89,845,855 (GRCm39) I194F possibly damaging Het
Phaf1 T C 8: 105,965,104 (GRCm39) probably benign Het
Pld1 G A 3: 28,125,426 (GRCm39) probably null Het
Podn T C 4: 107,875,055 (GRCm39) R164G probably benign Het
Qrfprl A T 6: 65,433,290 (GRCm39) H370L probably benign Het
R3hdm1 T A 1: 128,162,821 (GRCm39) L966Q probably damaging Het
Rasef A T 4: 73,662,301 (GRCm39) Y369* probably null Het
Ryr1 A T 7: 28,777,989 (GRCm39) V2176E probably damaging Het
Sec14l2 A G 11: 4,053,980 (GRCm39) L229P possibly damaging Het
Sec23a T C 12: 59,048,652 (GRCm39) S157G possibly damaging Het
Slit2 T A 5: 48,346,814 (GRCm39) W219R probably damaging Het
Smarcad1 G A 6: 65,033,400 (GRCm39) E128K probably damaging Het
Stk31 A T 6: 49,400,318 (GRCm39) N381I possibly damaging Het
Svop A G 5: 114,180,356 (GRCm39) Y264H probably damaging Het
Syt10 C T 15: 89,674,979 (GRCm39) D456N probably damaging Het
Ush2a T A 1: 188,607,066 (GRCm39) I3987N probably damaging Het
Ush2a T A 1: 188,643,738 (GRCm39) S4367T probably benign Het
Vdr A T 15: 97,765,052 (GRCm39) V229D probably damaging Het
Ywhaz G T 15: 36,790,959 (GRCm39) T88K possibly damaging Het
Zc3h10 A T 10: 128,380,672 (GRCm39) C228* probably null Het
Other mutations in Or2b6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02513:Or2b6 APN 13 21,823,510 (GRCm39) missense probably damaging 1.00
R0513:Or2b6 UTSW 13 21,823,119 (GRCm39) missense probably benign 0.26
R0928:Or2b6 UTSW 13 21,823,126 (GRCm39) missense probably damaging 1.00
R1440:Or2b6 UTSW 13 21,823,560 (GRCm39) missense probably benign 0.11
R1673:Or2b6 UTSW 13 21,823,214 (GRCm39) missense probably damaging 1.00
R2080:Or2b6 UTSW 13 21,823,606 (GRCm39) missense probably damaging 0.99
R2187:Or2b6 UTSW 13 21,823,555 (GRCm39) missense probably damaging 0.99
R2283:Or2b6 UTSW 13 21,823,190 (GRCm39) missense probably damaging 1.00
R2340:Or2b6 UTSW 13 21,822,757 (GRCm39) missense probably benign 0.03
R3690:Or2b6 UTSW 13 21,823,508 (GRCm39) missense probably damaging 1.00
R4108:Or2b6 UTSW 13 21,822,952 (GRCm39) missense probably damaging 1.00
R4739:Or2b6 UTSW 13 21,823,340 (GRCm39) missense possibly damaging 0.90
R4740:Or2b6 UTSW 13 21,823,340 (GRCm39) missense possibly damaging 0.90
R5335:Or2b6 UTSW 13 21,822,949 (GRCm39) missense probably damaging 1.00
R5790:Or2b6 UTSW 13 21,823,046 (GRCm39) missense probably benign
R6320:Or2b6 UTSW 13 21,823,418 (GRCm39) missense probably damaging 1.00
R7406:Or2b6 UTSW 13 21,823,316 (GRCm39) missense probably benign 0.16
R7508:Or2b6 UTSW 13 21,822,779 (GRCm39) missense probably benign 0.19
R8054:Or2b6 UTSW 13 21,823,119 (GRCm39) missense probably benign 0.26
Predicted Primers PCR Primer
(F):5'- ACGACCTTCGGCAGATTGGATTTTC -3'
(R):5'- TGTTACATCACATGCACAGTCCCAC -3'

Sequencing Primer
(F):5'- ATTTTCAAGATGGCACGGGC -3'
(R):5'- CAAATGCTGGTAAACTTACGCAG -3'
Posted On 2014-05-14