Incidental Mutation 'R2959:Tas2r106'
| ID |
255857 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tas2r106
|
| Ensembl Gene |
ENSMUSG00000057754 |
| Gene Name |
taste receptor, type 2, member 106 |
| Synonyms |
mt2r44, mGR06, T2R06, Tas2r6 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
R2959 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
131654923-131655849 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 131655068 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 261
(L261*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076043
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076756]
|
| AlphaFold |
Q7M724 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000076756
AA Change: L261*
|
| SMART Domains |
Protein: ENSMUSP00000076043
Gene: ENSMUSG00000057754
AA Change: L261*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
296 |
1.2e-88 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 12 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Angptl4 |
G |
A |
17: 33,996,008 (GRCm39) |
P323S |
possibly damaging |
Het |
| Cdk5rap2 |
ATGTG |
ATG |
4: 70,208,214 (GRCm39) |
|
probably null |
Het |
| Dnajc16 |
T |
A |
4: 141,493,856 (GRCm39) |
K571* |
probably null |
Het |
| Gm10608 |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
CAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGA |
9: 118,989,784 (GRCm39) |
|
probably null |
Het |
| Gm5407 |
A |
T |
16: 49,117,326 (GRCm39) |
|
noncoding transcript |
Het |
| Gpd2 |
C |
T |
2: 57,228,987 (GRCm39) |
R264* |
probably null |
Het |
| H2-M2 |
T |
C |
17: 37,794,345 (GRCm39) |
T26A |
probably benign |
Het |
| Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
| Prpf39 |
T |
C |
12: 65,089,297 (GRCm39) |
S12P |
probably damaging |
Het |
| Prss1 |
G |
T |
6: 41,440,172 (GRCm39) |
D170Y |
probably damaging |
Het |
| Satb1 |
T |
C |
17: 52,082,331 (GRCm39) |
D441G |
possibly damaging |
Het |
| Zfp719 |
T |
A |
7: 43,239,851 (GRCm39) |
S480T |
possibly damaging |
Het |
|
| Other mutations in Tas2r106 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00418:Tas2r106
|
APN |
6 |
131,654,922 (GRCm39) |
splice site |
probably null |
|
|
PIT4453001:Tas2r106
|
UTSW |
6 |
131,655,465 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0494:Tas2r106
|
UTSW |
6 |
131,655,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1900:Tas2r106
|
UTSW |
6 |
131,655,373 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2118:Tas2r106
|
UTSW |
6 |
131,655,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2120:Tas2r106
|
UTSW |
6 |
131,655,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2122:Tas2r106
|
UTSW |
6 |
131,655,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2124:Tas2r106
|
UTSW |
6 |
131,655,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3802:Tas2r106
|
UTSW |
6 |
131,655,329 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4913:Tas2r106
|
UTSW |
6 |
131,655,422 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5120:Tas2r106
|
UTSW |
6 |
131,655,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5771:Tas2r106
|
UTSW |
6 |
131,655,086 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5988:Tas2r106
|
UTSW |
6 |
131,655,606 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6187:Tas2r106
|
UTSW |
6 |
131,655,173 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6357:Tas2r106
|
UTSW |
6 |
131,654,925 (GRCm39) |
makesense |
probably null |
|
|
R6680:Tas2r106
|
UTSW |
6 |
131,655,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tas2r106
|
UTSW |
6 |
131,655,542 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7232:Tas2r106
|
UTSW |
6 |
131,655,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7340:Tas2r106
|
UTSW |
6 |
131,655,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7373:Tas2r106
|
UTSW |
6 |
131,655,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7689:Tas2r106
|
UTSW |
6 |
131,655,668 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8271:Tas2r106
|
UTSW |
6 |
131,655,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8273:Tas2r106
|
UTSW |
6 |
131,655,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACACCAGGCTATTTCTTGTGACC -3'
(R):5'- GGTGGCTATCATTACATGCTTCC -3'
Sequencing Primer
(F):5'- GTGACCATTCATTTCTCCATAAGTC -3'
(R):5'- CTTTGGAAACATAACAGAAAGATGC -3'
|
| Posted On |
2014-12-29 |
Incidental Mutation