Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02231:Zfp936'

285719

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp936

Ensembl Gene

ENSMUSG00000064194

Gene Name

zinc finger protein 936

Synonyms

EG435970, Gm9272, I1C0022H11Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.686) question?

Stock #

IGL02231

Quality Score

Status

Chromosome

Chromosomal Location

42763653-42841533 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 42836909 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145999 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072829] [ENSMUST00000072829] [ENSMUST00000200973] [ENSMUST00000200973] [ENSMUST00000202535] [ENSMUST00000205912]

AlphaFold

Q3ULA8

Predicted Effect

probably null
Transcript: ENSMUST00000072829

SMART Domains

Protein: ENSMUSP00000072608
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	3	65	5.32e-19	SMART
ZnF_C2H2	148	170	5.9e-3	SMART
ZnF_C2H2	176	198	5.9e-3	SMART
ZnF_C2H2	204	226	1.4e-4	SMART
ZnF_C2H2	232	254	1.2e-3	SMART
ZnF_C2H2	260	282	7.37e-4	SMART
ZnF_C2H2	288	310	2.27e-4	SMART
ZnF_C2H2	316	338	2.09e-3	SMART
ZnF_C2H2	344	366	1.45e-2	SMART
ZnF_C2H2	372	394	1.82e-3	SMART
ZnF_C2H2	400	422	2.53e-2	SMART
ZnF_C2H2	428	450	4.54e-4	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000072829

SMART Domains

Protein: ENSMUSP00000072608
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	3	65	5.32e-19	SMART
ZnF_C2H2	148	170	5.9e-3	SMART
ZnF_C2H2	176	198	5.9e-3	SMART
ZnF_C2H2	204	226	1.4e-4	SMART
ZnF_C2H2	232	254	1.2e-3	SMART
ZnF_C2H2	260	282	7.37e-4	SMART
ZnF_C2H2	288	310	2.27e-4	SMART
ZnF_C2H2	316	338	2.09e-3	SMART
ZnF_C2H2	344	366	1.45e-2	SMART
ZnF_C2H2	372	394	1.82e-3	SMART
ZnF_C2H2	400	422	2.53e-2	SMART
ZnF_C2H2	428	450	4.54e-4	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000200973

SMART Domains

Protein: ENSMUSP00000144191
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	4	66	1.4e-21	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000200973

SMART Domains

Protein: ENSMUSP00000144191
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	4	66	1.4e-21	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000202535

SMART Domains

Protein: ENSMUSP00000143800
Gene: ENSMUSG00000064194

Domain	Start	End	E-Value	Type
KRAB	4	66	2.3e-21	SMART
ZnF_C2H2	149	171	2.6e-5	SMART
ZnF_C2H2	177	199	2.5e-5	SMART
ZnF_C2H2	205	227	5.9e-7	SMART
ZnF_C2H2	233	255	5.1e-6	SMART
ZnF_C2H2	261	283	3.1e-6	SMART
ZnF_C2H2	289	311	9.4e-7	SMART
ZnF_C2H2	317	339	8.7e-6	SMART
ZnF_C2H2	345	367	6.3e-5	SMART
ZnF_C2H2	373	395	7.7e-6	SMART
ZnF_C2H2	401	423	1.1e-4	SMART
ZnF_C2H2	429	451	2e-6	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000205912

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alcam	T	A	16: 52,094,413 (GRCm39)		probably benign	Het
Alox15	A	C	11: 70,240,382 (GRCm39)	D266E	probably benign	Het
Atcay	A	T	10: 81,046,382 (GRCm39)	V314E	probably damaging	Het
Atp8b1	C	T	18: 64,683,455 (GRCm39)	G758R	possibly damaging	Het
Bltp2	G	A	11: 78,170,722 (GRCm39)	G1647D	probably benign	Het
Cacna2d4	T	A	6: 119,254,869 (GRCm39)		probably benign	Het
Celsr3	T	C	9: 108,719,709 (GRCm39)	V2429A	probably damaging	Het
Clspn	T	G	4: 126,453,021 (GRCm39)	D11E	probably damaging	Het
Cnot3	A	G	7: 3,661,209 (GRCm39)	T573A	probably benign	Het
Cyp2d34	A	T	15: 82,502,807 (GRCm39)	S140T	probably benign	Het
Edem1	A	G	6: 108,805,849 (GRCm39)	D50G	probably benign	Het
Emilin3	G	A	2: 160,750,435 (GRCm39)	T438I	probably damaging	Het
Etfdh	C	T	3: 79,525,700 (GRCm39)	V173I	probably damaging	Het
Fat2	T	C	11: 55,171,918 (GRCm39)	T2932A	probably damaging	Het
Fcrl1	G	A	3: 87,292,469 (GRCm39)	E154K	possibly damaging	Het
Fcrl1	A	T	3: 87,292,470 (GRCm39)	E154V	probably damaging	Het
G3bp1	T	A	11: 55,386,273 (GRCm39)	L244*	probably null	Het
Itgae	A	T	11: 72,981,448 (GRCm39)	K2M	possibly damaging	Het
Kcnq2	T	C	2: 180,723,508 (GRCm39)	I654V	probably benign	Het
Ksr2	C	T	5: 117,638,841 (GRCm39)	R82C	probably damaging	Het
Lrig3	A	T	10: 125,833,041 (GRCm39)	D305V	probably damaging	Het
Me1	T	C	9: 86,493,908 (GRCm39)	K322E	possibly damaging	Het
Med12l	T	A	3: 59,153,303 (GRCm39)	D1109E	probably damaging	Het
Mest	A	G	6: 30,740,772 (GRCm39)	K73E	possibly damaging	Het
Nup155	T	G	15: 8,173,548 (GRCm39)	L881R	probably damaging	Het
Ocln	A	T	13: 100,677,622 (GRCm39)	S2T	probably damaging	Het
Oosp3	T	C	19: 11,676,803 (GRCm39)	L54S	probably damaging	Het
Pkp3	G	A	7: 140,664,151 (GRCm39)	E443K	probably damaging	Het
Plk2	T	A	13: 110,536,603 (GRCm39)	C632S	probably benign	Het
Ptk6	C	T	2: 180,838,794 (GRCm39)	V320I	probably damaging	Het
Ptprt	A	T	2: 162,079,980 (GRCm39)	I273N	probably damaging	Het
Ptprt	A	G	2: 162,119,966 (GRCm39)		probably null	Het
Rab3gap2	T	C	1: 184,999,095 (GRCm39)		probably benign	Het
Rabgef1	G	A	5: 130,240,816 (GRCm39)	A312T	probably damaging	Het
Rabl6	T	A	2: 25,488,196 (GRCm39)	K109N	probably benign	Het
Rbp7	C	T	4: 149,539,334 (GRCm39)		probably null	Het
Reg3a	C	T	6: 78,359,224 (GRCm39)	H75Y	possibly damaging	Het
Rnf123	G	T	9: 107,943,598 (GRCm39)	P546T	probably benign	Het
Rnmt	C	A	18: 68,447,152 (GRCm39)	C345*	probably null	Het
Ror2	C	T	13: 53,264,764 (GRCm39)	S764N	probably damaging	Het
Slc14a2	C	T	18: 78,252,236 (GRCm39)	S25N	possibly damaging	Het
Spata16	G	T	3: 26,967,413 (GRCm39)	G388W	probably damaging	Het
Speg	C	T	1: 75,400,031 (GRCm39)	R2493W	probably damaging	Het
Thada	T	A	17: 84,736,125 (GRCm39)	D970V	probably damaging	Het
Tmem184c	A	G	8: 78,331,441 (GRCm39)	Y103H	probably damaging	Het
Ttn	A	T	2: 76,628,440 (GRCm39)	D12827E	probably damaging	Het
Utp20	A	G	10: 88,627,030 (GRCm39)	L976S	probably damaging	Het
Zfp318	C	T	17: 46,707,736 (GRCm39)	R265*	probably null	Het

Other mutations in Zfp936

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02245:Zfp936	APN	7	42,836,722 (GRCm39)	critical splice donor site	probably null
IGL02335:Zfp936	APN	7	42,836,691 (GRCm39)	missense	probably damaging	1.00
FR4340:Zfp936	UTSW	7	42,838,913 (GRCm39)	missense	possibly damaging	0.63
R0437:Zfp936	UTSW	7	42,838,734 (GRCm39)	missense	probably benign	0.00
R3899:Zfp936	UTSW	7	42,839,158 (GRCm39)	missense	possibly damaging	0.93
R4120:Zfp936	UTSW	7	42,839,630 (GRCm39)	missense	probably benign	0.10
R4406:Zfp936	UTSW	7	42,839,748 (GRCm39)	missense	possibly damaging	0.82
R4959:Zfp936	UTSW	7	42,839,034 (GRCm39)	missense	probably damaging	1.00
R5023:Zfp936	UTSW	7	42,836,681 (GRCm39)	missense	probably damaging	1.00
R5163:Zfp936	UTSW	7	42,839,664 (GRCm39)	missense	probably damaging	1.00
R5182:Zfp936	UTSW	7	42,839,331 (GRCm39)	missense	probably damaging	1.00
R5292:Zfp936	UTSW	7	42,838,759 (GRCm39)	nonsense	probably null
R5668:Zfp936	UTSW	7	42,839,858 (GRCm39)	missense	possibly damaging	0.93
R6057:Zfp936	UTSW	7	42,839,787 (GRCm39)	missense	probably benign	0.00
R6901:Zfp936	UTSW	7	42,839,467 (GRCm39)	missense	probably damaging	1.00
R7139:Zfp936	UTSW	7	42,839,715 (GRCm39)	missense	possibly damaging	0.54
R7258:Zfp936	UTSW	7	42,839,803 (GRCm39)	missense	probably damaging	1.00
R7440:Zfp936	UTSW	7	42,836,685 (GRCm39)	missense	probably damaging	1.00
R7537:Zfp936	UTSW	7	42,839,239 (GRCm39)	nonsense	probably null
R7561:Zfp936	UTSW	7	42,839,339 (GRCm39)	missense	probably damaging	0.98
R7662:Zfp936	UTSW	7	42,839,336 (GRCm39)	nonsense	probably null
R7775:Zfp936	UTSW	7	42,839,720 (GRCm39)	missense	possibly damaging	0.70
R7778:Zfp936	UTSW	7	42,839,720 (GRCm39)	missense	possibly damaging	0.70
R8016:Zfp936	UTSW	7	42,838,848 (GRCm39)	missense	possibly damaging	0.61
R8121:Zfp936	UTSW	7	42,839,547 (GRCm39)	missense	possibly damaging	0.55
R9012:Zfp936	UTSW	7	42,839,416 (GRCm39)	nonsense	probably null
R9058:Zfp936	UTSW	7	42,839,196 (GRCm39)	missense	probably benign	0.32
R9188:Zfp936	UTSW	7	42,839,768 (GRCm39)	missense	probably benign	0.00
R9236:Zfp936	UTSW	7	42,836,922 (GRCm39)	missense	probably benign	0.00
R9596:Zfp936	UTSW	7	42,839,834 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16