Incidental Mutation 'IGL02347:Vmn2r83'
| ID |
289325 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r83
|
| Ensembl Gene |
ENSMUSG00000091381 |
| Gene Name |
vomeronasal 2, receptor 83 |
| Synonyms |
EG625029 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.141)
|
| Stock # |
IGL02347
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
79304792-79327988 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 79316067 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 488
(T488A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131426
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167976]
|
| AlphaFold |
E9Q0G7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167976
AA Change: T488A
PolyPhen 2
Score 0.752 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000131426
Gene: ENSMUSG00000091381
AA Change: T488A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
79 |
473 |
1.5e-33 |
PFAM |
|
Pfam:NCD3G
|
516 |
569 |
6.2e-22 |
PFAM |
|
Pfam:7tm_3
|
602 |
837 |
8.1e-52 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9830107B12Rik |
T |
A |
17: 48,452,835 (GRCm39) |
K35* |
probably null |
Het |
| Adad2 |
G |
T |
8: 120,343,408 (GRCm39) |
G546V |
probably damaging |
Het |
| Bccip |
A |
G |
7: 133,311,105 (GRCm39) |
K7E |
probably benign |
Het |
| C8b |
G |
A |
4: 104,644,151 (GRCm39) |
E273K |
probably benign |
Het |
| Car12 |
T |
A |
9: 66,671,629 (GRCm39) |
V352D |
possibly damaging |
Het |
| Cyp2d11 |
G |
A |
15: 82,274,681 (GRCm39) |
R299C |
probably benign |
Het |
| Dnah10 |
A |
C |
5: 124,910,487 (GRCm39) |
|
probably null |
Het |
| Eddm13 |
A |
G |
7: 6,272,883 (GRCm39) |
I79M |
possibly damaging |
Het |
| Egf |
A |
T |
3: 129,472,026 (GRCm39) |
N1199K |
probably benign |
Het |
| Ehbp1l1 |
A |
G |
19: 5,769,600 (GRCm39) |
W568R |
possibly damaging |
Het |
| Eif1ad14 |
T |
C |
12: 87,886,359 (GRCm39) |
D90G |
probably damaging |
Het |
| Emc3 |
A |
G |
6: 113,497,533 (GRCm39) |
M106T |
possibly damaging |
Het |
| Fam13b |
T |
C |
18: 34,587,757 (GRCm39) |
K514E |
probably damaging |
Het |
| Fhdc1 |
G |
A |
3: 84,352,042 (GRCm39) |
A1061V |
possibly damaging |
Het |
| Frg2f1 |
A |
C |
4: 119,387,929 (GRCm39) |
L190R |
probably damaging |
Het |
| Frmpd1 |
A |
G |
4: 45,270,023 (GRCm39) |
|
probably null |
Het |
| Glis3 |
A |
G |
19: 28,509,283 (GRCm39) |
F234L |
probably benign |
Het |
| Grap2 |
T |
C |
15: 80,530,557 (GRCm39) |
|
probably benign |
Het |
| H2-M10.2 |
T |
A |
17: 36,596,505 (GRCm39) |
E113D |
probably benign |
Het |
| Itgb6 |
T |
C |
2: 60,441,756 (GRCm39) |
T685A |
probably benign |
Het |
| Mrpl19 |
A |
T |
6: 81,938,992 (GRCm39) |
M270K |
probably damaging |
Het |
| Msantd4 |
G |
T |
9: 4,384,734 (GRCm39) |
|
probably benign |
Het |
| Msr1 |
G |
T |
8: 40,085,778 (GRCm39) |
T34K |
probably damaging |
Het |
| Npc1 |
C |
T |
18: 12,332,691 (GRCm39) |
V780M |
probably benign |
Het |
| Nsun6 |
A |
G |
2: 15,034,831 (GRCm39) |
|
probably benign |
Het |
| Nt5c2 |
A |
G |
19: 46,912,695 (GRCm39) |
|
probably benign |
Het |
| Nucb2 |
A |
C |
7: 116,135,113 (GRCm39) |
Q340P |
probably benign |
Het |
| Nup50l |
A |
T |
6: 96,142,511 (GRCm39) |
Y178N |
probably damaging |
Het |
| Or2l13b |
A |
G |
16: 19,349,529 (GRCm39) |
L47P |
probably damaging |
Het |
| Or3a1b |
C |
T |
11: 74,012,397 (GRCm39) |
T94I |
probably benign |
Het |
| Osgin1 |
A |
G |
8: 120,172,277 (GRCm39) |
E357G |
probably benign |
Het |
| Pabpc6 |
C |
T |
17: 9,887,993 (GRCm39) |
R186K |
probably benign |
Het |
| Pex1 |
A |
G |
5: 3,653,350 (GRCm39) |
K83R |
probably damaging |
Het |
| Ppid |
A |
G |
3: 79,502,526 (GRCm39) |
I82V |
probably benign |
Het |
| Pygl |
C |
T |
12: 70,248,666 (GRCm39) |
G318S |
probably benign |
Het |
| Rcn1 |
A |
T |
2: 105,229,471 (GRCm39) |
V27E |
probably benign |
Het |
| Rnaseh1 |
A |
T |
12: 28,707,629 (GRCm39) |
|
probably benign |
Het |
| Rnf148 |
A |
G |
6: 23,654,729 (GRCm39) |
V89A |
probably benign |
Het |
| Siglecf |
G |
A |
7: 43,001,145 (GRCm39) |
V38I |
possibly damaging |
Het |
| Slc13a5 |
T |
C |
11: 72,149,780 (GRCm39) |
|
probably null |
Het |
| Slc26a4 |
C |
T |
12: 31,578,853 (GRCm39) |
|
probably benign |
Het |
| Sos2 |
A |
T |
12: 69,643,520 (GRCm39) |
D953E |
probably benign |
Het |
| Strbp |
A |
C |
2: 37,535,660 (GRCm39) |
V16G |
probably benign |
Het |
| Sycp1 |
A |
T |
3: 102,800,863 (GRCm39) |
M567K |
probably benign |
Het |
| Tedc2 |
A |
C |
17: 24,439,584 (GRCm39) |
V19G |
probably damaging |
Het |
| Tjp1 |
A |
G |
7: 64,950,812 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
T |
2: 76,539,564 (GRCm39) |
V26147E |
probably damaging |
Het |
| Vmn1r86 |
A |
G |
7: 12,836,574 (GRCm39) |
S51P |
probably damaging |
Het |
| Zfp541 |
A |
G |
7: 15,817,390 (GRCm39) |
Y945C |
probably damaging |
Het |
|
| Other mutations in Vmn2r83 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00226:Vmn2r83
|
APN |
10 |
79,314,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01096:Vmn2r83
|
APN |
10 |
79,313,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01542:Vmn2r83
|
APN |
10 |
79,314,846 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL01803:Vmn2r83
|
APN |
10 |
79,304,894 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02110:Vmn2r83
|
APN |
10 |
79,327,534 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02417:Vmn2r83
|
APN |
10 |
79,314,881 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02544:Vmn2r83
|
APN |
10 |
79,317,293 (GRCm39) |
splice site |
probably benign |
|
|
IGL02683:Vmn2r83
|
APN |
10 |
79,327,115 (GRCm39) |
missense |
probably benign |
|
|
IGL02976:Vmn2r83
|
APN |
10 |
79,304,832 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4378001:Vmn2r83
|
UTSW |
10 |
79,304,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4468001:Vmn2r83
|
UTSW |
10 |
79,313,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0092:Vmn2r83
|
UTSW |
10 |
79,327,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1391:Vmn2r83
|
UTSW |
10 |
79,314,931 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1539:Vmn2r83
|
UTSW |
10 |
79,327,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1575:Vmn2r83
|
UTSW |
10 |
79,314,956 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2033:Vmn2r83
|
UTSW |
10 |
79,327,653 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3916:Vmn2r83
|
UTSW |
10 |
79,314,744 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3967:Vmn2r83
|
UTSW |
10 |
79,327,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4840:Vmn2r83
|
UTSW |
10 |
79,313,682 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5063:Vmn2r83
|
UTSW |
10 |
79,314,921 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5630:Vmn2r83
|
UTSW |
10 |
79,327,785 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5707:Vmn2r83
|
UTSW |
10 |
79,327,183 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5980:Vmn2r83
|
UTSW |
10 |
79,314,626 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6294:Vmn2r83
|
UTSW |
10 |
79,313,688 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6302:Vmn2r83
|
UTSW |
10 |
79,304,837 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6769:Vmn2r83
|
UTSW |
10 |
79,313,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6986:Vmn2r83
|
UTSW |
10 |
79,316,093 (GRCm39) |
missense |
probably benign |
|
|
R7221:Vmn2r83
|
UTSW |
10 |
79,316,001 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7376:Vmn2r83
|
UTSW |
10 |
79,314,790 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7431:Vmn2r83
|
UTSW |
10 |
79,327,306 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7501:Vmn2r83
|
UTSW |
10 |
79,327,771 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7526:Vmn2r83
|
UTSW |
10 |
79,327,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Vmn2r83
|
UTSW |
10 |
79,314,956 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7881:Vmn2r83
|
UTSW |
10 |
79,314,261 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7939:Vmn2r83
|
UTSW |
10 |
79,314,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Vmn2r83
|
UTSW |
10 |
79,317,313 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8364:Vmn2r83
|
UTSW |
10 |
79,316,037 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8802:Vmn2r83
|
UTSW |
10 |
79,314,261 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8947:Vmn2r83
|
UTSW |
10 |
79,304,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8969:Vmn2r83
|
UTSW |
10 |
79,313,853 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8983:Vmn2r83
|
UTSW |
10 |
79,327,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Vmn2r83
|
UTSW |
10 |
79,316,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9082:Vmn2r83
|
UTSW |
10 |
79,304,894 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9390:Vmn2r83
|
UTSW |
10 |
79,317,322 (GRCm39) |
nonsense |
probably null |
|
|
X0026:Vmn2r83
|
UTSW |
10 |
79,314,486 (GRCm39) |
missense |
probably benign |
|
|
X0026:Vmn2r83
|
UTSW |
10 |
79,304,849 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r83
|
UTSW |
10 |
79,314,756 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
| Posted On |
2015-04-16 |
Incidental Mutation