Incidental Mutation 'IGL02110:Vmn2r83'
ID280061
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r83
Ensembl Gene ENSMUSG00000091381
Gene Namevomeronasal 2, receptor 83
SynonymsEG625029
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #IGL02110
Quality Score
Status
Chromosome10
Chromosomal Location79468943-79492154 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 79491700 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 714 (V714A)
Ref Sequence ENSEMBL: ENSMUSP00000131426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167976]
Predicted Effect possibly damaging
Transcript: ENSMUST00000167976
AA Change: V714A

PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000131426
Gene: ENSMUSG00000091381
AA Change: V714A

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 79 473 1.5e-33 PFAM
Pfam:NCD3G 516 569 6.2e-22 PFAM
Pfam:7tm_3 602 837 8.1e-52 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931409K22Rik A G 5: 24,548,084 probably benign Het
Apol7e A G 15: 77,714,348 probably null Het
Arhgef40 C T 14: 51,989,405 T302M probably damaging Het
Bap1 T C 14: 31,257,414 L458P probably damaging Het
Bbs12 A G 3: 37,319,187 E43G probably benign Het
Bod1l C T 5: 41,816,453 C2506Y probably damaging Het
Ccdc170 A G 10: 4,541,885 probably null Het
Chpf2 A G 5: 24,591,712 E552G probably damaging Het
Comp T A 8: 70,373,639 I23N probably benign Het
Cxcl2 T C 5: 90,904,352 probably benign Het
Dctn5 T C 7: 122,135,151 F73L probably damaging Het
Ddx5 T C 11: 106,785,009 E285G probably damaging Het
Ddx60 T G 8: 62,017,247 probably null Het
Dhcr24 T A 4: 106,573,801 I229N probably damaging Het
Dnah7a G A 1: 53,411,580 T3897I possibly damaging Het
Dvl2 T A 11: 70,008,016 probably benign Het
Dytn A T 1: 63,647,473 V346E possibly damaging Het
Eepd1 T C 9: 25,603,402 probably benign Het
Fbln2 G T 6: 91,234,102 A343S probably benign Het
Flywch1 T C 17: 23,763,092 probably null Het
Gckr A T 5: 31,298,738 T81S possibly damaging Het
Gm6139 T A 5: 129,623,592 noncoding transcript Het
Gpcpd1 A T 2: 132,530,610 C657* probably null Het
Greb1l A G 18: 10,515,271 I89V probably damaging Het
Hdac4 G A 1: 91,984,405 P421S probably benign Het
Klhl1 A G 14: 96,136,603 L669P probably benign Het
Mios A G 6: 8,215,565 R254G probably damaging Het
Mmp19 A G 10: 128,794,858 N116D probably damaging Het
Muc5b T A 7: 141,847,716 C566* probably null Het
Nadsyn1 T C 7: 143,813,427 Y141C probably damaging Het
Nlrp4d T C 7: 10,382,564 noncoding transcript Het
Nob1 A T 8: 107,416,172 *160R probably null Het
Olfr1295 C T 2: 111,564,907 C179Y probably damaging Het
Olfr1366 T A 13: 21,537,942 Q21L possibly damaging Het
Olfr346 A G 2: 36,688,685 T228A probably benign Het
Olfr455 A G 6: 42,538,179 V281A possibly damaging Het
Olfr504 C A 7: 108,565,079 A239S probably damaging Het
Olfr571 C T 7: 102,909,195 V215I probably benign Het
Phc1 T C 6: 122,322,035 D658G possibly damaging Het
Pitx2 T G 3: 129,218,817 S299A probably damaging Het
Plekha7 C A 7: 116,154,628 probably null Het
Ptgfr A G 3: 151,835,460 V137A probably damaging Het
Ptprb T C 10: 116,331,203 probably benign Het
Rasl2-9 C T 7: 5,125,347 A195T probably benign Het
Ripor3 T A 2: 167,994,706 Q121L possibly damaging Het
Sgsh G T 11: 119,352,806 A30E probably damaging Het
Sis G T 3: 72,928,699 C852* probably null Het
Slc17a9 A G 2: 180,732,576 probably benign Het
Slco6b1 A T 1: 96,987,882 noncoding transcript Het
Smarca2 A G 19: 26,672,740 Y704C possibly damaging Het
Spata6 A T 4: 111,784,806 H291L possibly damaging Het
Stra8 T C 6: 34,930,354 probably benign Het
Taldo1 T C 7: 141,402,734 probably benign Het
Tmco6 T C 18: 36,735,166 probably benign Het
Tmpo A C 10: 91,162,865 S353R probably damaging Het
Tpr A T 1: 150,435,742 Q1757L probably damaging Het
Ubn1 T C 16: 5,081,890 probably benign Het
Zfp407 G T 18: 84,559,040 A1316D probably benign Het
Zzef1 T A 11: 72,913,112 I2560N probably damaging Het
Other mutations in Vmn2r83
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Vmn2r83 APN 10 79478971 missense probably damaging 1.00
IGL01096:Vmn2r83 APN 10 79477828 missense probably damaging 1.00
IGL01542:Vmn2r83 APN 10 79479012 missense probably benign 0.30
IGL01803:Vmn2r83 APN 10 79469060 missense probably benign 0.01
IGL02347:Vmn2r83 APN 10 79480233 missense possibly damaging 0.75
IGL02417:Vmn2r83 APN 10 79479047 missense probably benign 0.00
IGL02544:Vmn2r83 APN 10 79481459 splice site probably benign
IGL02683:Vmn2r83 APN 10 79491281 missense probably benign
IGL02976:Vmn2r83 APN 10 79468998 missense probably benign 0.00
PIT4378001:Vmn2r83 UTSW 10 79469015 missense probably benign 0.00
PIT4468001:Vmn2r83 UTSW 10 79478050 missense probably damaging 1.00
R0092:Vmn2r83 UTSW 10 79491964 missense probably damaging 1.00
R1391:Vmn2r83 UTSW 10 79479097 missense probably damaging 0.96
R1539:Vmn2r83 UTSW 10 79491925 missense probably damaging 1.00
R1575:Vmn2r83 UTSW 10 79479122 missense probably damaging 0.98
R2033:Vmn2r83 UTSW 10 79491819 missense probably benign 0.03
R3916:Vmn2r83 UTSW 10 79478910 missense probably benign 0.01
R3967:Vmn2r83 UTSW 10 79491320 missense probably benign 0.00
R4840:Vmn2r83 UTSW 10 79477848 missense possibly damaging 0.73
R5063:Vmn2r83 UTSW 10 79479087 missense probably benign 0.04
R5630:Vmn2r83 UTSW 10 79491951 missense possibly damaging 0.94
R5707:Vmn2r83 UTSW 10 79491349 missense possibly damaging 0.53
R5980:Vmn2r83 UTSW 10 79478792 missense probably benign 0.04
R6294:Vmn2r83 UTSW 10 79477854 missense probably damaging 0.99
R6302:Vmn2r83 UTSW 10 79469003 missense possibly damaging 0.95
R6769:Vmn2r83 UTSW 10 79478022 missense probably damaging 1.00
R6986:Vmn2r83 UTSW 10 79480259 missense probably benign
R7221:Vmn2r83 UTSW 10 79480167 missense probably benign 0.02
X0026:Vmn2r83 UTSW 10 79469015 missense probably benign 0.00
X0026:Vmn2r83 UTSW 10 79478652 missense probably benign
Posted On2015-04-16