Incidental Mutation 'IGL00936:Cyth4'
ID 29066
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyth4
Ensembl Gene ENSMUSG00000018008
Gene Name cytohesin 4
Synonyms Pscd4, 2510004M07Rik, 5830469K17Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL00936
Quality Score
Status
Chromosome 15
Chromosomal Location 78481247-78506219 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 78504113 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 361 (E361G)
Ref Sequence ENSEMBL: ENSMUSP00000042698 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043069] [ENSMUST00000229248] [ENSMUST00000231168]
AlphaFold Q80YW0
Predicted Effect probably benign
Transcript: ENSMUST00000043069
AA Change: E361G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000042698
Gene: ENSMUSG00000018008
AA Change: E361G

DomainStartEndE-ValueType
Sec7 58 243 1.05e-90 SMART
PH 260 377 2.11e-21 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000229248
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230583
Predicted Effect probably benign
Transcript: ENSMUST00000231168
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Allele List at MGI
Other mutations in this stock
Total: 8 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik A G 16: 4,682,510 (GRCm39) T1053A probably benign Het
Col13a1 A G 10: 61,712,069 (GRCm39) M332T probably damaging Het
Cstdc1 A C 2: 148,627,724 (GRCm39) T124P probably benign Het
Mrps22 T C 9: 98,479,034 (GRCm39) T114A possibly damaging Het
Nup155 T C 15: 8,157,889 (GRCm39) probably benign Het
Or5b113 T A 19: 13,341,988 (GRCm39) probably benign Het
Slc35g3 T C 11: 69,651,317 (GRCm39) probably null Het
Taar7f T C 10: 23,926,066 (GRCm39) V220A probably benign Het
Other mutations in Cyth4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0522:Cyth4 UTSW 15 78,499,985 (GRCm39) missense possibly damaging 0.67
R0584:Cyth4 UTSW 15 78,494,078 (GRCm39) splice site probably null
R2018:Cyth4 UTSW 15 78,492,371 (GRCm39) missense probably damaging 1.00
R3804:Cyth4 UTSW 15 78,494,002 (GRCm39) missense probably damaging 1.00
R3811:Cyth4 UTSW 15 78,488,849 (GRCm39) missense probably damaging 1.00
R4728:Cyth4 UTSW 15 78,486,913 (GRCm39) missense probably benign 0.01
R4738:Cyth4 UTSW 15 78,490,074 (GRCm39) missense probably benign 0.02
R5392:Cyth4 UTSW 15 78,491,185 (GRCm39) missense probably damaging 1.00
R5594:Cyth4 UTSW 15 78,491,275 (GRCm39) splice site probably null
R6414:Cyth4 UTSW 15 78,492,346 (GRCm39) missense probably damaging 0.97
R7241:Cyth4 UTSW 15 78,491,245 (GRCm39) missense probably benign 0.38
R7472:Cyth4 UTSW 15 78,490,094 (GRCm39) missense probably damaging 1.00
R8253:Cyth4 UTSW 15 78,486,937 (GRCm39) missense probably benign 0.09
R8372:Cyth4 UTSW 15 78,481,335 (GRCm39) start gained probably benign
R8952:Cyth4 UTSW 15 78,486,937 (GRCm39) missense probably benign 0.09
Z1177:Cyth4 UTSW 15 78,504,119 (GRCm39) missense probably damaging 1.00
Posted On 2013-04-17