Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02542:Rnf25'

297711

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rnf25

Ensembl Gene

ENSMUSG00000026171

Gene Name

ring finger protein 25

Synonyms

AO7, 0610009H16Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02542

Quality Score

Status

Chromosome

Chromosomal Location

74632907-74640556 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 74633260 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 364 (E364G)

Ref Sequence

ENSEMBL: ENSMUSP00000109350 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027357] [ENSMUST00000027358] [ENSMUST00000113721] [ENSMUST00000113732] [ENSMUST00000113733] [ENSMUST00000127938] [ENSMUST00000135140] [ENSMUST00000154874] [ENSMUST00000132081]

AlphaFold

Q9QZR0

Predicted Effect

probably benign
Transcript: ENSMUST00000027357
AA Change: E365G

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000027357
Gene: ENSMUSG00000026171
AA Change: E365G

Domain	Start	End	E-Value	Type
RWD	18	127	4.66e-31	SMART
RING	134	198	2.87e-5	SMART
low complexity region	368	378	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000027358

SMART Domains

Protein: ENSMUSP00000027358
Gene: ENSMUSG00000026172

Domain	Start	End	E-Value	Type
BCS1_N	23	191	1.29e-86	SMART
AAA	222	357	3.23e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113721
AA Change: E364G

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000109350
Gene: ENSMUSG00000026171
AA Change: E364G

Domain	Start	End	E-Value	Type
RWD	18	127	4.66e-31	SMART
RING	134	197	3.53e-5	SMART
low complexity region	367	377	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000113732

SMART Domains

Protein: ENSMUSP00000109361
Gene: ENSMUSG00000026172

Domain	Start	End	E-Value	Type
BCS1_N	23	191	1.29e-86	SMART
AAA	222	357	3.23e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000113733

SMART Domains

Protein: ENSMUSP00000109362
Gene: ENSMUSG00000026172

Domain	Start	End	E-Value	Type
BCS1_N	23	191	1.29e-86	SMART
AAA	222	357	3.23e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000127938

SMART Domains

Protein: ENSMUSP00000116973
Gene: ENSMUSG00000026171

Domain	Start	End	E-Value	Type
RING	23	87	2.87e-5	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128491

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147464

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151003

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149649

Predicted Effect

probably benign
Transcript: ENSMUST00000135140

Predicted Effect

probably benign
Transcript: ENSMUST00000154874

SMART Domains

Protein: ENSMUSP00000120646
Gene: ENSMUSG00000026171

Domain	Start	End	E-Value	Type
RWD	1	94	6.36e-15	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000132081

Predicted Effect

probably benign
Transcript: ENSMUST00000136078

SMART Domains

Protein: ENSMUSP00000117692
Gene: ENSMUSG00000026171

Domain	Start	End	E-Value	Type
RWD	24	123	1.97e-20	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahsa2	T	A	11: 23,440,559 (GRCm39)	T231S	possibly damaging	Het
Arfgef1	A	G	1: 10,243,067 (GRCm39)	L1091P	probably benign	Het
Arhgap32	A	T	9: 32,166,944 (GRCm39)	K527M	probably damaging	Het
Caap1	T	C	4: 94,438,742 (GRCm39)	N149S	probably benign	Het
Cc2d2a	A	G	5: 43,846,252 (GRCm39)		probably benign	Het
Cdk13	A	T	13: 17,902,763 (GRCm39)	I929K	probably damaging	Het
Fan1	A	G	7: 64,014,408 (GRCm39)	Y608H	probably damaging	Het
Foxj3	A	G	4: 119,477,540 (GRCm39)	N416S	unknown	Het
Gm20547	T	C	17: 35,076,236 (GRCm39)	S1151G	possibly damaging	Het
Ighv1-80	A	T	12: 115,876,199 (GRCm39)	I39N	probably damaging	Het
Igkv11-125	A	C	6: 67,890,991 (GRCm39)	E102A	probably damaging	Het
Mdc1	C	A	17: 36,164,048 (GRCm39)	P1199T	probably damaging	Het
Negr1	T	C	3: 156,267,862 (GRCm39)	S11P	probably damaging	Het
Oxsr1	T	C	9: 119,071,801 (GRCm39)	R477G	possibly damaging	Het
Pappa	T	A	4: 65,094,518 (GRCm39)	F514L	probably damaging	Het
Pde6c	G	T	19: 38,166,578 (GRCm39)	D707Y	probably damaging	Het
Phtf1	T	C	3: 103,901,222 (GRCm39)		probably benign	Het
Piezo2	T	A	18: 63,165,995 (GRCm39)	I2079F	probably damaging	Het
Ptprm	T	C	17: 67,227,145 (GRCm39)	D668G	probably benign	Het
Ptprq	T	C	10: 107,498,416 (GRCm39)	Y887C	probably damaging	Het
Rax	T	C	18: 66,071,701 (GRCm39)	E62G	possibly damaging	Het
Sipa1l3	A	T	7: 29,087,490 (GRCm39)	D578E	probably damaging	Het
Slc14a2	T	G	18: 78,252,302 (GRCm39)	D3A	probably benign	Het
Slc28a3	A	G	13: 58,721,284 (GRCm39)	Y294H	probably damaging	Het
Slit1	T	C	19: 41,615,687 (GRCm39)	T811A	probably damaging	Het
Sorcs2	T	C	5: 36,183,286 (GRCm39)	T996A	probably damaging	Het
Tmem132b	A	C	5: 125,699,558 (GRCm39)	Q73P	probably damaging	Het
Tnrc6b	T	A	15: 80,786,553 (GRCm39)	I1275N	possibly damaging	Het
Vasp	A	T	7: 18,998,705 (GRCm39)	D17E	probably damaging	Het
Wdr19	A	G	5: 65,388,414 (GRCm39)	T700A	probably benign	Het
Ythdc2	T	G	18: 44,973,308 (GRCm39)	L315W	probably damaging	Het
Zfp385c	A	G	11: 100,520,742 (GRCm39)	V306A	probably damaging	Het

Other mutations in Rnf25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03268:Rnf25	APN	1	74,638,217 (GRCm39)	unclassified	probably benign
R1570:Rnf25	UTSW	1	74,634,426 (GRCm39)	missense	probably damaging	1.00
R1740:Rnf25	UTSW	1	74,637,886 (GRCm39)	missense	probably damaging	1.00
R2086:Rnf25	UTSW	1	74,633,126 (GRCm39)	missense	probably damaging	0.99
R2939:Rnf25	UTSW	1	74,635,047 (GRCm39)	missense	possibly damaging	0.50
R2940:Rnf25	UTSW	1	74,635,047 (GRCm39)	missense	possibly damaging	0.50
R4556:Rnf25	UTSW	1	74,638,264 (GRCm39)	missense	probably damaging	1.00
R4770:Rnf25	UTSW	1	74,633,099 (GRCm39)	missense	probably damaging	1.00
R5075:Rnf25	UTSW	1	74,634,803 (GRCm39)	missense	probably benign
R5394:Rnf25	UTSW	1	74,634,411 (GRCm39)	missense	probably damaging	1.00
R6319:Rnf25	UTSW	1	74,634,890 (GRCm39)	missense	probably damaging	1.00
R6960:Rnf25	UTSW	1	74,634,403 (GRCm39)	missense	possibly damaging	0.66
R8039:Rnf25	UTSW	1	74,633,123 (GRCm39)	missense	probably damaging	0.98

Posted On

2015-04-16