Incidental Mutation 'IGL02569:Zfp111'
| ID |
298942 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp111
|
| Ensembl Gene |
ENSMUSG00000087598 |
| Gene Name |
zinc finger protein 111 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02569
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
23890760-23907574 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23906494 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 2
(T2A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083169
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056683]
[ENSMUST00000073833]
[ENSMUST00000086006]
|
| AlphaFold |
Q9R164 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000056683
|
| SMART Domains |
Protein: ENSMUSP00000129484
Gene: ENSMUSG00000087598
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
9 |
64 |
1.8e-21 |
SMART |
|
low complexity region
|
114 |
128 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
210 |
232 |
2.3e-7 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
5.7e-4 |
SMART |
|
ZnF_C2H2
|
294 |
316 |
3.3e-4 |
SMART |
|
ZnF_C2H2
|
322 |
343 |
4.3e-1 |
SMART |
|
ZnF_C2H2
|
349 |
371 |
4.5e-8 |
SMART |
|
ZnF_C2H2
|
377 |
399 |
2.1e-6 |
SMART |
|
ZnF_C2H2
|
405 |
427 |
8e-6 |
SMART |
|
ZnF_C2H2
|
433 |
455 |
9.9e-5 |
SMART |
|
ZnF_C2H2
|
461 |
481 |
4.3e-2 |
SMART |
|
ZnF_C2H2
|
489 |
511 |
2.7e-5 |
SMART |
|
ZnF_C2H2
|
517 |
539 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
545 |
567 |
1.8e-5 |
SMART |
|
ZnF_C2H2
|
573 |
595 |
3.5e-6 |
SMART |
|
ZnF_C2H2
|
601 |
623 |
2.9e-6 |
SMART |
|
ZnF_C2H2
|
629 |
651 |
1.3e-6 |
SMART |
|
ZnF_C2H2
|
657 |
679 |
2.2e-5 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000073833
AA Change: T2A
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000083174
Gene: ENSMUSG00000087598
AA Change: T2A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
63 |
4.03e-19 |
SMART |
|
low complexity region
|
113 |
127 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
209 |
231 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
265 |
287 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
293 |
315 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
321 |
342 |
1.01e2 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
1e-5 |
SMART |
|
ZnF_C2H2
|
376 |
398 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
404 |
426 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
432 |
454 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
460 |
480 |
9.96e0 |
SMART |
|
ZnF_C2H2
|
488 |
510 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
516 |
538 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
600 |
622 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
628 |
650 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
656 |
678 |
5.14e-3 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000086006
AA Change: T2A
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000083169
Gene: ENSMUSG00000087598
AA Change: T2A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
63 |
4.03e-19 |
SMART |
|
low complexity region
|
113 |
127 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
209 |
231 |
5.29e-5 |
SMART |
|
ZnF_C2H2
|
265 |
287 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
293 |
315 |
7.67e-2 |
SMART |
|
ZnF_C2H2
|
321 |
342 |
1.01e2 |
SMART |
|
ZnF_C2H2
|
348 |
370 |
1e-5 |
SMART |
|
ZnF_C2H2
|
376 |
398 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
404 |
426 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
432 |
454 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
460 |
480 |
9.96e0 |
SMART |
|
ZnF_C2H2
|
488 |
510 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
516 |
538 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
544 |
566 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
572 |
594 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
600 |
622 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
628 |
650 |
3.21e-4 |
SMART |
|
ZnF_C2H2
|
656 |
678 |
5.14e-3 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142218
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148050
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000160563
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca1 |
T |
C |
4: 53,034,061 (GRCm39) |
D2223G |
probably damaging |
Het |
| Brd1 |
A |
G |
15: 88,598,132 (GRCm39) |
L538P |
probably damaging |
Het |
| Cacna2d2 |
T |
C |
9: 107,391,245 (GRCm39) |
V424A |
probably damaging |
Het |
| Capg |
A |
C |
6: 72,538,032 (GRCm39) |
E306A |
probably damaging |
Het |
| Cdc14b |
T |
C |
13: 64,373,428 (GRCm39) |
Y115C |
probably benign |
Het |
| Crat |
G |
A |
2: 30,294,542 (GRCm39) |
R509W |
probably damaging |
Het |
| Ddx60 |
A |
G |
8: 62,477,985 (GRCm39) |
N1594S |
possibly damaging |
Het |
| Fabp2 |
T |
C |
3: 122,689,113 (GRCm39) |
F18L |
probably damaging |
Het |
| Fam187a |
A |
G |
11: 102,776,985 (GRCm39) |
K263R |
probably benign |
Het |
| Fam227a |
C |
T |
15: 79,518,323 (GRCm39) |
C323Y |
probably benign |
Het |
| Fas |
A |
G |
19: 34,297,962 (GRCm39) |
E210G |
possibly damaging |
Het |
| Fgfbp1 |
A |
G |
5: 44,136,569 (GRCm39) |
F241S |
probably damaging |
Het |
| Gramd1a |
A |
T |
7: 30,829,932 (GRCm39) |
|
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,573,244 (GRCm39) |
M2135K |
probably benign |
Het |
| Ikbkb |
G |
T |
8: 23,183,899 (GRCm39) |
Q84K |
probably damaging |
Het |
| Kcnk9 |
T |
C |
15: 72,384,426 (GRCm39) |
T251A |
probably benign |
Het |
| Mphosph9 |
C |
A |
5: 124,435,634 (GRCm39) |
E600* |
probably null |
Het |
| Or2ag1 |
T |
A |
7: 106,313,793 (GRCm39) |
I32L |
probably benign |
Het |
| Or2ag1b |
T |
A |
7: 106,288,849 (GRCm39) |
T30S |
probably benign |
Het |
| Pde1a |
C |
A |
2: 79,698,602 (GRCm39) |
K341N |
probably benign |
Het |
| Prune2 |
A |
G |
19: 17,156,223 (GRCm39) |
N2792S |
probably damaging |
Het |
| Scart2 |
A |
C |
7: 139,878,275 (GRCm39) |
I885L |
probably benign |
Het |
| Slc17a3 |
A |
G |
13: 24,030,285 (GRCm39) |
Y132C |
probably damaging |
Het |
| Srrm1 |
G |
A |
4: 135,052,415 (GRCm39) |
P658L |
unknown |
Het |
| St6galnac1 |
T |
C |
11: 116,658,528 (GRCm39) |
D312G |
probably damaging |
Het |
| Tardbp |
A |
G |
4: 148,703,639 (GRCm39) |
|
probably null |
Het |
| Tex9 |
C |
T |
9: 72,385,645 (GRCm39) |
V8I |
probably damaging |
Het |
| Tpr |
T |
A |
1: 150,301,382 (GRCm39) |
|
probably benign |
Het |
| Ttll8 |
C |
T |
15: 88,818,129 (GRCm39) |
W182* |
probably null |
Het |
| Vmn2r61 |
G |
A |
7: 41,926,070 (GRCm39) |
G525E |
probably damaging |
Het |
|
| Other mutations in Zfp111 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02619:Zfp111
|
APN |
7 |
23,899,113 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
FR4737:Zfp111
|
UTSW |
7 |
23,899,230 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Zfp111
|
UTSW |
7 |
23,899,232 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Zfp111
|
UTSW |
7 |
23,898,462 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0514:Zfp111
|
UTSW |
7 |
23,898,568 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3837:Zfp111
|
UTSW |
7 |
23,898,891 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4682:Zfp111
|
UTSW |
7 |
23,898,563 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4844:Zfp111
|
UTSW |
7 |
23,898,801 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6105:Zfp111
|
UTSW |
7 |
23,902,791 (GRCm39) |
splice site |
probably null |
|
|
R6175:Zfp111
|
UTSW |
7 |
23,897,554 (GRCm39) |
missense |
unknown |
|
|
R7276:Zfp111
|
UTSW |
7 |
23,898,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7584:Zfp111
|
UTSW |
7 |
23,898,025 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8682:Zfp111
|
UTSW |
7 |
23,897,983 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9655:Zfp111
|
UTSW |
7 |
23,898,543 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9746:Zfp111
|
UTSW |
7 |
23,898,067 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
X0018:Zfp111
|
UTSW |
7 |
23,899,416 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Posted On |
2015-04-16 |
Incidental Mutation