Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02626:Gm28557'

301063

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm28557

Ensembl Gene

ENSMUSG00000100235

Gene Name

predicted gene 28557

Synonyms

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02626

Quality Score

Status

Chromosome

Chromosomal Location

67217463-67256668 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 67223008 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 8 (T8S)

Ref Sequence

ENSEMBL: ENSMUSP00000105364 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109742] [ENSMUST00000109743] [ENSMUST00000186303] [ENSMUST00000190566]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000109742
AA Change: T8S

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000105364
Gene: ENSMUSG00000058883
AA Change: T8S

Domain	Start	End	E-Value	Type
KRAB	5	65	3.75e-28	SMART
ZnF_C2H2	81	103	1.12e-3	SMART
ZnF_C2H2	109	131	5.14e-3	SMART
ZnF_C2H2	137	159	1.1e-2	SMART
ZnF_C2H2	165	187	6.78e-3	SMART
ZnF_C2H2	193	215	1.47e-3	SMART
ZnF_C2H2	221	243	7.78e-3	SMART
ZnF_C2H2	249	271	1.95e-3	SMART
ZnF_C2H2	277	299	5.21e-4	SMART
ZnF_C2H2	305	327	7.9e-4	SMART
ZnF_C2H2	333	355	8.34e-3	SMART
ZnF_C2H2	361	383	1.3e-4	SMART
ZnF_C2H2	389	411	4.87e-4	SMART
ZnF_C2H2	417	439	5.14e-3	SMART
ZnF_C2H2	445	467	1.2e-3	SMART
ZnF_C2H2	473	495	1.72e-4	SMART
ZnF_C2H2	501	523	1.6e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109743
AA Change: T20S

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)

SMART Domains

Protein: ENSMUSP00000105365
Gene: ENSMUSG00000058883
AA Change: T20S

Domain	Start	End	E-Value	Type
KRAB	17	77	3.75e-28	SMART
ZnF_C2H2	93	115	1.12e-3	SMART
ZnF_C2H2	121	143	5.14e-3	SMART
ZnF_C2H2	149	171	1.1e-2	SMART
ZnF_C2H2	177	199	6.78e-3	SMART
ZnF_C2H2	205	227	1.47e-3	SMART
ZnF_C2H2	233	255	7.78e-3	SMART
ZnF_C2H2	261	283	1.95e-3	SMART
ZnF_C2H2	289	311	5.21e-4	SMART
ZnF_C2H2	317	339	7.9e-4	SMART
ZnF_C2H2	345	367	8.34e-3	SMART
ZnF_C2H2	373	395	1.3e-4	SMART
ZnF_C2H2	401	423	4.87e-4	SMART
ZnF_C2H2	429	451	5.14e-3	SMART
ZnF_C2H2	457	479	1.2e-3	SMART
ZnF_C2H2	485	507	1.72e-4	SMART
ZnF_C2H2	513	535	1.6e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185856

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185954

Predicted Effect

probably benign
Transcript: ENSMUST00000186303

SMART Domains

Protein: ENSMUSP00000140296
Gene: ENSMUSG00000100235

Domain	Start	End	E-Value	Type
KRAB	1	32	9.7e-3	SMART
ZnF_C2H2	47	69	1.8e-6	SMART
ZnF_C2H2	75	97	6.7e-5	SMART
ZnF_C2H2	103	125	7.6e-6	SMART
ZnF_C2H2	131	153	7.6e-6	SMART
ZnF_C2H2	159	181	1.4e-7	SMART
ZnF_C2H2	187	209	7.6e-6	SMART
ZnF_C2H2	215	237	5.5e-5	SMART
ZnF_C2H2	243	265	8.9e-7	SMART
ZnF_C2H2	271	293	2e-6	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000190566

SMART Domains

Protein: ENSMUSP00000139928
Gene: ENSMUSG00000058883

Domain	Start	End	E-Value	Type
KRAB	1	32	1.6e-3	SMART
ZnF_C2H2	48	70	4.7e-6	SMART
ZnF_C2H2	76	98	2.1e-5	SMART
ZnF_C2H2	104	126	4.6e-5	SMART
ZnF_C2H2	132	154	2.9e-5	SMART
ZnF_C2H2	160	182	6.3e-6	SMART
ZnF_C2H2	188	210	3.3e-5	SMART
ZnF_C2H2	216	238	8.2e-6	SMART
ZnF_C2H2	244	266	2.2e-6	SMART
ZnF_C2H2	272	294	3.4e-6	SMART
ZnF_C2H2	300	322	3.6e-5	SMART
ZnF_C2H2	328	350	5.5e-7	SMART
ZnF_C2H2	356	378	2.1e-6	SMART
ZnF_C2H2	384	406	2.1e-5	SMART
ZnF_C2H2	412	434	5e-6	SMART
ZnF_C2H2	440	462	7.2e-7	SMART
ZnF_C2H2	468	490	6.8e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223556

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223904

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000224641

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930407I10Rik	A	G	15: 81,949,810 (GRCm39)	K1236E	probably damaging	Het
Actl7a	A	T	4: 56,744,353 (GRCm39)	E293D	possibly damaging	Het
Adamts2	T	C	11: 50,667,082 (GRCm39)	Y460H	probably damaging	Het
Aoc1	G	A	6: 48,883,044 (GRCm39)	V307I	probably benign	Het
Ar	C	T	X: 97,358,492 (GRCm39)	H756Y	probably damaging	Het
Atg3	C	T	16: 45,004,048 (GRCm39)	R224W	probably benign	Het
Atp5po	G	A	16: 91,483,201 (GRCm39)	P47S	probably damaging	Het
Bicd1	A	G	6: 149,311,054 (GRCm39)	E43G	probably damaging	Het
Ccdc88c	A	G	12: 100,934,059 (GRCm39)		probably benign	Het
Cd33	A	G	7: 43,179,736 (GRCm39)		probably benign	Het
Cd36	T	A	5: 18,002,126 (GRCm39)	R292*	probably null	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdh23	T	C	10: 60,227,580 (GRCm39)	D1167G	probably damaging	Het
Cdk5rap1	A	G	2: 154,207,880 (GRCm39)		probably null	Het
Chd6	A	G	2: 160,881,270 (GRCm39)		probably benign	Het
Chd7	A	T	4: 8,826,519 (GRCm39)	Y961F	probably damaging	Het
Cpe	T	C	8: 65,145,829 (GRCm39)	E52G	probably benign	Het
Cpne5	C	T	17: 29,379,311 (GRCm39)	G491S	probably damaging	Het
Csmd3	A	T	15: 47,567,503 (GRCm39)		probably benign	Het
Ctbp2	T	A	7: 132,600,940 (GRCm39)	T608S	probably benign	Het
Cybb	A	G	X: 9,335,439 (GRCm39)		probably null	Het
Daam2	T	C	17: 49,797,282 (GRCm39)	T168A	possibly damaging	Het
Dnah5	G	T	15: 28,307,422 (GRCm39)	V1717F	possibly damaging	Het
Dse	G	A	10: 34,029,158 (GRCm39)	T644I	probably damaging	Het
Dtd2	A	C	12: 52,051,708 (GRCm39)	Y45*	probably null	Het
Fgfr1op2	T	A	6: 146,491,509 (GRCm39)	M124K	probably benign	Het
Flii	T	C	11: 60,610,685 (GRCm39)	D537G	probably benign	Het
Fntb	T	A	12: 76,944,145 (GRCm39)	I217N	probably benign	Het
Foxi1	A	G	11: 34,155,860 (GRCm39)	S257P	probably benign	Het
Fyn	G	A	10: 39,402,798 (GRCm39)	R190H	probably damaging	Het
Gramd1b	T	C	9: 40,209,306 (GRCm39)	K873E	probably damaging	Het
Grb10	T	C	11: 11,895,503 (GRCm39)	T329A	probably benign	Het
Haus5	A	G	7: 30,356,675 (GRCm39)	L477P	probably damaging	Het
Hectd4	A	T	5: 121,491,944 (GRCm39)	E3761V	possibly damaging	Het
Ift172	T	C	5: 31,421,840 (GRCm39)	I930V	probably benign	Het
Itprid1	T	A	6: 55,945,631 (GRCm39)	V784D	probably benign	Het
Izumo2	A	G	7: 44,358,560 (GRCm39)		probably benign	Het
Map4k4	A	G	1: 40,053,257 (GRCm39)		probably benign	Het
Morc1	A	G	16: 48,436,123 (GRCm39)	S753G	probably damaging	Het
Mpzl2	C	T	9: 44,955,590 (GRCm39)	T167I	probably damaging	Het
Mta2	T	A	19: 8,926,532 (GRCm39)	I491N	probably damaging	Het
Myo18b	A	T	5: 113,025,951 (GRCm39)	I33N	unknown	Het
Nub1	C	T	5: 24,908,462 (GRCm39)	H404Y	possibly damaging	Het
Or10ak13	T	C	4: 118,639,531 (GRCm39)	M84V	probably damaging	Het
Or4f58	A	T	2: 111,851,458 (GRCm39)	V247E	probably damaging	Het
Or5d47	T	C	2: 87,804,068 (GRCm39)	N314D	probably benign	Het
Or8d2b	T	C	9: 38,788,784 (GRCm39)	L104S	probably benign	Het
Ralyl	A	T	3: 13,842,094 (GRCm39)	M77L	probably benign	Het
Rap1gap	T	A	4: 137,454,364 (GRCm39)	V649E	probably benign	Het
Rnf40	C	A	7: 127,195,744 (GRCm39)	Q663K	probably damaging	Het
Slc22a18	T	C	7: 143,052,837 (GRCm39)	L354P	probably damaging	Het
Slc9a8	T	C	2: 167,309,597 (GRCm39)		probably benign	Het
Surf4	C	T	2: 26,815,619 (GRCm39)		probably null	Het
T	A	T	17: 8,654,069 (GRCm39)	N85Y	probably damaging	Het
Tanc1	A	G	2: 59,630,216 (GRCm39)	E732G	probably damaging	Het
Tas2r138	A	G	6: 40,589,649 (GRCm39)	V199A	possibly damaging	Het
Trim43b	T	C	9: 88,967,541 (GRCm39)	Y365C	possibly damaging	Het
Ubd	T	C	17: 37,506,573 (GRCm39)	L153P	probably damaging	Het
Xpnpep2	A	C	X: 47,215,786 (GRCm39)	M513L	probably benign	Het
Zar1l	C	T	5: 150,441,210 (GRCm39)	G139R	probably damaging	Het
Zc3hav1	T	G	6: 38,309,926 (GRCm39)	T299P	probably damaging	Het
Zfp236	C	A	18: 82,676,120 (GRCm39)		probably benign	Het

Other mutations in Gm28557

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01533:Gm28557	APN	13	67,219,396 (GRCm39)	nonsense	probably null
IGL02013:Gm28557	APN	13	67,219,116 (GRCm39)	missense	probably benign	0.01
IGL02609:Gm28557	APN	13	67,219,083 (GRCm39)	nonsense	probably null

Posted On

2015-04-16