Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02680:Ifna1'

303320

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna1

Ensembl Gene

ENSMUSG00000095498

Gene Name

interferon alpha 1

Synonyms

Ifa1

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02680

Quality Score

Status

Chromosome

Chromosomal Location

88768324-88768893 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 88768523 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 67 (D67G)

Ref Sequence

ENSEMBL: ENSMUSP00000092580 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094972]

AlphaFold

P01572

Predicted Effect

probably benign
Transcript: ENSMUST00000094972
AA Change: D67G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000092580
Gene: ENSMUSG00000095498
AA Change: D67G

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	5.84e-76	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921524L21Rik	T	A	18: 6,635,949 (GRCm39)		probably benign	Het
Aldh1a3	C	A	7: 66,055,895 (GRCm39)	V299F	probably damaging	Het
Ankar	A	G	1: 72,709,275 (GRCm39)	Y747H	probably damaging	Het
Armc9	T	C	1: 86,180,000 (GRCm39)	I107T	probably damaging	Het
Atmin	A	T	8: 117,684,236 (GRCm39)	D632V	probably damaging	Het
Atp5pd	C	A	11: 115,306,840 (GRCm39)		probably null	Het
Cadps2	T	C	6: 23,838,895 (GRCm39)	E81G	probably damaging	Het
Cep162	A	G	9: 87,128,797 (GRCm39)	V67A	possibly damaging	Het
Cfap100	C	T	6: 90,389,217 (GRCm39)	V335I	probably benign	Het
Dmtf1	A	T	5: 9,180,381 (GRCm39)	D181E	probably benign	Het
Efcab14	T	A	4: 115,597,615 (GRCm39)	I70N	probably damaging	Het
Frzb	T	C	2: 80,254,970 (GRCm39)	T189A	possibly damaging	Het
Fstl3	G	A	10: 79,614,506 (GRCm39)	W69*	probably null	Het
Gjb3	C	T	4: 127,219,815 (GRCm39)	C239Y	probably damaging	Het
Inpp5d	A	G	1: 87,629,205 (GRCm39)	T397A	possibly damaging	Het
Myh11	G	T	16: 14,027,384 (GRCm39)	H1283Q	probably benign	Het
Naip6	A	G	13: 100,420,256 (GRCm39)	V1338A	probably benign	Het
Obscn	A	G	11: 58,890,846 (GRCm39)	S7229P	unknown	Het
Or1l4b	A	T	2: 37,036,427 (GRCm39)	I68F	probably damaging	Het
Pfkp	G	A	13: 6,650,708 (GRCm39)		probably benign	Het
Pop1	T	A	15: 34,502,619 (GRCm39)	I102K	probably damaging	Het
Ppp1r21	A	G	17: 88,891,290 (GRCm39)	M732V	probably benign	Het
Rsc1a1	A	G	4: 141,412,408 (GRCm39)	V168A	probably benign	Het
Scd2	G	A	19: 44,289,685 (GRCm39)	V227I	probably benign	Het
Scn10a	T	A	9: 119,495,125 (GRCm39)	Y372F	probably damaging	Het
Slc35c2	G	T	2: 165,124,055 (GRCm39)	T94K	probably damaging	Het
Slc41a2	A	G	10: 83,119,728 (GRCm39)	Y345H	probably benign	Het
Slc5a11	T	C	7: 122,864,854 (GRCm39)	S387P	probably damaging	Het
Smg7	T	A	1: 152,721,145 (GRCm39)	N727I	probably benign	Het
Steap2	A	T	5: 5,723,474 (GRCm39)	F469I	probably benign	Het
Tex2	T	A	11: 106,459,058 (GRCm39)		probably benign	Het
Tmem79	A	G	3: 88,240,270 (GRCm39)	L226P	probably damaging	Het
Tnfrsf14	G	T	4: 155,008,927 (GRCm39)	C165*	probably null	Het
Trim21	A	G	7: 102,208,870 (GRCm39)	V283A	probably benign	Het
Vmn2r16	A	T	5: 109,487,948 (GRCm39)	M274L	probably benign	Het

Other mutations in Ifna1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02630:Ifna1	APN	4	88,768,496 (GRCm39)	missense	possibly damaging	0.47
IGL02675:Ifna1	APN	4	88,768,670 (GRCm39)	missense	probably damaging	1.00
IGL02681:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02709:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02710:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02712:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
IGL02721:Ifna1	APN	4	88,768,523 (GRCm39)	missense	probably benign	0.01
R1630:Ifna1	UTSW	4	88,768,566 (GRCm39)	missense	probably benign	0.00
R2897:Ifna1	UTSW	4	88,768,450 (GRCm39)	missense	probably benign
R6150:Ifna1	UTSW	4	88,768,349 (GRCm39)	missense	probably null	0.34
R8233:Ifna1	UTSW	4	88,768,628 (GRCm39)	missense	possibly damaging	0.61
R9181:Ifna1	UTSW	4	88,768,453 (GRCm39)	missense	probably benign	0.13

Posted On

2015-04-16