Incidental Mutation 'IGL02700:Lgals12'
ID 304108
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lgals12
Ensembl Gene ENSMUSG00000024972
Gene Name lectin, galactose binding, soluble 12
Synonyms galectin-12, galectin-related inhibitor of proliferation, GRIP1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02700
Quality Score
Status
Chromosome 19
Chromosomal Location 7574025-7584558 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 7575455 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 294 (A294T)
Ref Sequence ENSEMBL: ENSMUSP00000124610 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079902] [ENSMUST00000099729] [ENSMUST00000159983]
AlphaFold Q91VD1
Predicted Effect probably benign
Transcript: ENSMUST00000079902
AA Change: A281T

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000078824
Gene: ENSMUSG00000024972
AA Change: A281T

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 181 301 3.6e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099729
AA Change: A294T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000097318
Gene: ENSMUSG00000024972
AA Change: A294T

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159983
AA Change: A294T

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000124610
Gene: ENSMUSG00000024972
AA Change: A294T

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018B08Rik C A 8: 122,262,161 (GRCm39) probably null Het
Acacb A G 5: 114,356,942 (GRCm39) Y1291C probably damaging Het
Agtpbp1 C T 13: 59,676,233 (GRCm39) C179Y probably damaging Het
Capn15 T C 17: 26,181,982 (GRCm39) D609G probably damaging Het
Cnnm3 T A 1: 36,552,189 (GRCm39) F400I probably damaging Het
Dst A C 1: 34,301,201 (GRCm39) E1189A probably damaging Het
Gcnt1 G A 19: 17,306,780 (GRCm39) T315I probably damaging Het
H2-M1 T C 17: 36,982,161 (GRCm39) I147V possibly damaging Het
Hk1 T C 10: 62,120,590 (GRCm39) N536D probably damaging Het
Klhl5 C T 5: 65,288,773 (GRCm39) Q12* probably null Het
Mideas T C 12: 84,199,636 (GRCm39) N1028S probably benign Het
Mki67 G T 7: 135,309,931 (GRCm39) S173R probably benign Het
Nedd4l C T 18: 65,342,751 (GRCm39) R755C probably damaging Het
Obox5 A G 7: 15,492,888 (GRCm39) D281G possibly damaging Het
Or4f6 T C 2: 111,839,036 (GRCm39) D165G probably benign Het
Pacs2 T A 12: 113,025,330 (GRCm39) I494N probably damaging Het
Pax5 G T 4: 44,682,722 (GRCm39) T141K probably damaging Het
Phf21b T C 15: 84,687,662 (GRCm39) N230S probably benign Het
Rab3gap1 G T 1: 127,866,342 (GRCm39) A841S probably benign Het
Siglecf T C 7: 43,001,802 (GRCm39) L204P probably damaging Het
Slc39a10 G A 1: 46,857,288 (GRCm39) A696V probably damaging Het
Snca G A 6: 60,804,521 (GRCm39) T22I possibly damaging Het
Syvn1 A G 19: 6,097,973 (GRCm39) T4A probably benign Het
Usp36 T C 11: 118,166,983 (GRCm39) N298S possibly damaging Het
Usp42 A T 5: 143,702,883 (GRCm39) S579R probably benign Het
Vezf1 T C 11: 87,964,129 (GRCm39) S94P probably damaging Het
Other mutations in Lgals12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02442:Lgals12 APN 19 7,584,019 (GRCm39) splice site probably benign
IGL02630:Lgals12 APN 19 7,578,607 (GRCm39) splice site probably benign
R0129:Lgals12 UTSW 19 7,580,403 (GRCm39) missense probably damaging 0.99
R1398:Lgals12 UTSW 19 7,581,322 (GRCm39) splice site probably benign
R1421:Lgals12 UTSW 19 7,584,079 (GRCm39) missense probably benign 0.08
R1548:Lgals12 UTSW 19 7,581,677 (GRCm39) missense probably benign 0.12
R1697:Lgals12 UTSW 19 7,581,530 (GRCm39) missense possibly damaging 0.91
R2075:Lgals12 UTSW 19 7,576,210 (GRCm39) missense possibly damaging 0.81
R2192:Lgals12 UTSW 19 7,578,606 (GRCm39) splice site probably null
R2253:Lgals12 UTSW 19 7,584,130 (GRCm39) start gained probably benign
R4256:Lgals12 UTSW 19 7,584,081 (GRCm39) missense possibly damaging 0.93
R4738:Lgals12 UTSW 19 7,581,464 (GRCm39) missense probably benign 0.01
R5495:Lgals12 UTSW 19 7,581,495 (GRCm39) missense probably damaging 1.00
R5810:Lgals12 UTSW 19 7,584,085 (GRCm39) missense probably benign 0.00
R6139:Lgals12 UTSW 19 7,581,742 (GRCm39) missense probably benign 0.07
R7414:Lgals12 UTSW 19 7,581,335 (GRCm39) missense probably damaging 1.00
R8755:Lgals12 UTSW 19 7,581,345 (GRCm39) missense possibly damaging 0.95
R8920:Lgals12 UTSW 19 7,576,166 (GRCm39) missense possibly damaging 0.55
R9334:Lgals12 UTSW 19 7,578,086 (GRCm39) missense probably benign 0.01
R9441:Lgals12 UTSW 19 7,581,356 (GRCm39) missense probably damaging 1.00
X0067:Lgals12 UTSW 19 7,581,329 (GRCm39) splice site probably null
Z1177:Lgals12 UTSW 19 7,575,445 (GRCm39) missense probably benign 0.03
Posted On 2015-04-16