Incidental Mutation 'R4199:Lcn9'
ID 318664
Institutional Source Beutler Lab
Gene Symbol Lcn9
Ensembl Gene ENSMUSG00000023210
Gene Name lipocalin 9
Synonyms
MMRRC Submission 041029-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R4199 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 25713165-25715549 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 25714773 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 171 (T171A)
Ref Sequence ENSEMBL: ENSMUSP00000023978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023978]
AlphaFold Q9D267
Predicted Effect probably benign
Transcript: ENSMUST00000023978
AA Change: T171A

PolyPhen 2 Score 0.148 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000023978
Gene: ENSMUSG00000023210
AA Change: T171A

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Lipocalin 34 174 6e-37 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN9, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankhd1 C G 18: 36,794,101 (GRCm39) probably benign Het
Cbarp G T 10: 79,971,326 (GRCm39) H173Q probably damaging Het
Ccna1 G A 3: 54,954,736 (GRCm39) A177V possibly damaging Het
Ces1f A G 8: 93,983,517 (GRCm39) F497L probably benign Het
Cic TCCCCC TCCCCCCC 7: 24,991,095 (GRCm39) probably null Het
Disc1 C T 8: 125,875,198 (GRCm39) T556I probably damaging Het
Dnah3 C T 7: 119,522,061 (GRCm39) G4033D probably damaging Het
Dnmt1 A G 9: 20,849,414 (GRCm39) S63P probably benign Het
Eml2 G A 7: 18,913,364 (GRCm39) A121T probably benign Het
Eps8 T C 6: 137,491,325 (GRCm39) N351S probably damaging Het
Fbxo34 T A 14: 47,768,454 (GRCm39) W605R probably damaging Het
Foxg1 T A 12: 49,432,082 (GRCm39) S272T possibly damaging Het
Gal3st3 T A 19: 5,357,808 (GRCm39) Y394* probably null Het
Gga1 A G 15: 78,773,275 (GRCm39) E301G probably damaging Het
Ifitm5 T A 7: 140,529,149 (GRCm39) *153Y probably null Het
Ighg2b G T 12: 113,270,907 (GRCm39) P110Q probably damaging Het
Il17rb C T 14: 29,718,601 (GRCm39) D494N probably benign Het
Irf2bp2 C A 8: 127,318,313 (GRCm39) A418S probably damaging Het
Lcorl T C 5: 45,891,130 (GRCm39) K408E possibly damaging Het
Myh14 T A 7: 44,264,927 (GRCm39) R1653* probably null Het
Naa16 A T 14: 79,593,311 (GRCm39) H420Q probably damaging Het
Nol8 T A 13: 49,815,224 (GRCm39) V426E possibly damaging Het
Or1i2 A T 10: 78,447,901 (GRCm39) D191E possibly damaging Het
Orc4 G A 2: 48,827,501 (GRCm39) P31S probably benign Het
Pabir3 G A X: 52,382,376 (GRCm39) R94H possibly damaging Het
Papln C T 12: 83,830,166 (GRCm39) T1012I probably null Het
Pkd1 A G 17: 24,789,004 (GRCm39) T921A probably benign Het
Pknox1 C A 17: 31,821,790 (GRCm39) Q294K probably damaging Het
Ppp2ca A G 11: 51,989,928 (GRCm39) N18S probably benign Het
Serpinb9d A G 13: 33,386,657 (GRCm39) probably null Het
Sfxn5 T A 6: 85,192,724 (GRCm39) E319V probably benign Het
Slc1a1 A G 19: 28,878,852 (GRCm39) K197R probably benign Het
Spef2 A G 15: 9,667,366 (GRCm39) F774S probably damaging Het
Syp A G X: 7,506,166 (GRCm39) probably null Het
Zfp276 A G 8: 123,994,564 (GRCm39) T544A probably damaging Het
Other mutations in Lcn9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01952:Lcn9 APN 2 25,714,550 (GRCm39) missense probably damaging 1.00
IGL02417:Lcn9 APN 2 25,713,692 (GRCm39) missense possibly damaging 0.91
PIT4418001:Lcn9 UTSW 2 25,714,553 (GRCm39) missense probably damaging 1.00
R1479:Lcn9 UTSW 2 25,713,715 (GRCm39) splice site probably benign
R1657:Lcn9 UTSW 2 25,714,722 (GRCm39) missense probably benign 0.17
R4526:Lcn9 UTSW 2 25,714,520 (GRCm39) missense possibly damaging 0.85
R4570:Lcn9 UTSW 2 25,713,591 (GRCm39) missense probably benign 0.04
R5232:Lcn9 UTSW 2 25,714,067 (GRCm39) critical splice donor site probably null
R5577:Lcn9 UTSW 2 25,713,663 (GRCm39) missense probably damaging 1.00
R5849:Lcn9 UTSW 2 25,713,268 (GRCm39) critical splice donor site probably null
R6059:Lcn9 UTSW 2 25,714,737 (GRCm39) missense possibly damaging 0.62
R7748:Lcn9 UTSW 2 25,714,926 (GRCm39) makesense probably null
R9257:Lcn9 UTSW 2 25,714,784 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- ACCCTATCTGTTTGGGAATCC -3'
(R):5'- TTCACATACCAGAAGGCCTG -3'

Sequencing Primer
(F):5'- CACTGGGAGGGCATCTTC -3'
(R):5'- AGAAGGCCTGGCTGGTTC -3'
Posted On 2015-06-10