Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02815:Vmn2r9'

360753

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r9

Ensembl Gene

ENSMUSG00000091624

Gene Name

vomeronasal 2, receptor 9

Synonyms

EG435864

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.113) question?

Stock #

IGL02815

Quality Score

Status

Chromosome

Chromosomal Location

108990813-109000376 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 108990856 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 835 (D835G)

Ref Sequence

ENSEMBL: ENSMUSP00000129520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170419]

AlphaFold

K7N6Z8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170419
AA Change: D835G

PolyPhen 2 Score 0.695 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000129520
Gene: ENSMUSG00000091624
AA Change: D835G

Domain	Start	End	E-Value	Type
signal peptide	1	26	N/A	INTRINSIC
Pfam:ANF_receptor	77	412	8.1e-29	PFAM
Pfam:NCD3G	507	561	2.3e-16	PFAM
Pfam:7tm_3	592	829	3.4e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810009J06Rik	A	T	6: 40,941,729 (GRCm39)	I3F	probably benign	Het
Alms1	G	A	6: 85,644,939 (GRCm39)		probably null	Het
Ap3m1	T	C	14: 21,086,750 (GRCm39)	D393G	probably damaging	Het
Arfgef3	T	A	10: 18,528,299 (GRCm39)	I363F	probably damaging	Het
Col19a1	T	A	1: 24,324,332 (GRCm39)		probably null	Het
Csnk2a1	G	T	2: 152,116,005 (GRCm39)		probably benign	Het
Dnmt3a	G	A	12: 3,954,226 (GRCm39)		probably null	Het
Emc2	T	A	15: 43,371,326 (GRCm39)		probably benign	Het
Epm2aip1	T	C	9: 111,102,628 (GRCm39)	S534P	probably benign	Het
Farp2	A	C	1: 93,488,007 (GRCm39)	N78T	probably damaging	Het
Fut8	T	A	12: 77,411,857 (GRCm39)	N106K	probably benign	Het
Gc	A	G	5: 89,605,518 (GRCm39)		probably null	Het
Gemin5	T	C	11: 58,037,235 (GRCm39)	Y660C	probably damaging	Het
Gfpt2	T	A	11: 49,714,084 (GRCm39)	D280E	possibly damaging	Het
Il16	T	C	7: 83,300,249 (GRCm39)	E348G	probably damaging	Het
Ints1	G	A	5: 139,741,037 (GRCm39)	T1874M	probably damaging	Het
Klrb1b	A	G	6: 128,797,937 (GRCm39)	L52P	probably damaging	Het
Lamb3	A	T	1: 193,007,863 (GRCm39)		probably benign	Het
Med17	A	C	9: 15,173,563 (GRCm39)	M637R	probably damaging	Het
Myo18b	A	G	5: 112,957,601 (GRCm39)	L1454P	probably damaging	Het
Mysm1	A	T	4: 94,845,285 (GRCm39)		probably null	Het
Naip5	T	C	13: 100,359,239 (GRCm39)	T666A	probably benign	Het
Nbas	T	A	12: 13,360,267 (GRCm39)	S348T	probably damaging	Het
Pex1	A	T	5: 3,686,797 (GRCm39)	K1226M	probably damaging	Het
Pi4ka	A	G	16: 17,176,753 (GRCm39)		probably benign	Het
Pigr	T	A	1: 130,769,558 (GRCm39)	V123D	probably damaging	Het
Pilra	G	A	5: 137,829,567 (GRCm39)	P163S	probably benign	Het
Plekha4	T	C	7: 45,187,836 (GRCm39)	S303P	probably damaging	Het
Prrc2b	A	G	2: 32,094,265 (GRCm39)	E549G	probably damaging	Het
Ptchd3	C	T	11: 121,732,430 (GRCm39)	S440L	probably benign	Het
Rock2	A	G	12: 17,016,702 (GRCm39)		probably benign	Het
Scn1a	A	G	2: 66,155,202 (GRCm39)	S586P	probably damaging	Het
Slc38a6	T	A	12: 73,338,979 (GRCm39)	H95Q	probably damaging	Het
Spata31d1d	A	T	13: 59,874,678 (GRCm39)	N952K	possibly damaging	Het
Stard10	T	A	7: 100,993,205 (GRCm39)	C254S	probably benign	Het
Taar8a	A	T	10: 23,953,278 (GRCm39)	Y294F	probably benign	Het
Tm7sf3	A	T	6: 146,514,971 (GRCm39)		probably null	Het
Tnfrsf8	A	T	4: 145,025,348 (GRCm39)	V75D	possibly damaging	Het
Tor1aip1	C	T	1: 155,911,662 (GRCm39)	R107H	probably damaging	Het
Trpc4	C	T	3: 54,206,695 (GRCm39)		probably benign	Het
Unc13c	A	G	9: 73,447,545 (GRCm39)	L1885P	possibly damaging	Het
Zfp462	A	T	4: 55,051,303 (GRCm39)	I1172F	probably damaging	Het

Other mutations in Vmn2r9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00920:Vmn2r9	APN	5	108,995,890 (GRCm39)	missense	possibly damaging	0.79
IGL00972:Vmn2r9	APN	5	108,996,903 (GRCm39)	missense	probably benign	0.02
IGL01102:Vmn2r9	APN	5	108,990,811 (GRCm39)	splice site	probably null
IGL01892:Vmn2r9	APN	5	108,995,700 (GRCm39)	missense	probably damaging	1.00
IGL02086:Vmn2r9	APN	5	108,995,433 (GRCm39)	missense	probably damaging	1.00
IGL02118:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02119:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02120:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02121:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02123:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02131:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02132:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02171:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02185:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02186:Vmn2r9	APN	5	108,991,502 (GRCm39)	missense	probably damaging	1.00
IGL02346:Vmn2r9	APN	5	108,990,850 (GRCm39)	missense	probably benign	0.07
IGL02508:Vmn2r9	APN	5	108,996,067 (GRCm39)	missense	possibly damaging	0.70
IGL03077:Vmn2r9	APN	5	108,996,173 (GRCm39)	splice site	probably benign
IGL03269:Vmn2r9	APN	5	108,995,820 (GRCm39)	missense	probably damaging	1.00
IGL03293:Vmn2r9	APN	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r9	UTSW	5	108,990,991 (GRCm39)	missense	probably damaging	1.00
R0328:Vmn2r9	UTSW	5	108,995,405 (GRCm39)	missense	probably benign	0.11
R0382:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R0521:Vmn2r9	UTSW	5	108,996,154 (GRCm39)	nonsense	probably null
R0975:Vmn2r9	UTSW	5	108,991,169 (GRCm39)	missense	probably damaging	1.00
R1216:Vmn2r9	UTSW	5	108,995,440 (GRCm39)	missense	probably damaging	1.00
R1458:Vmn2r9	UTSW	5	108,996,850 (GRCm39)	missense	probably benign	0.44
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1469:Vmn2r9	UTSW	5	108,991,694 (GRCm39)	missense	probably benign
R1704:Vmn2r9	UTSW	5	108,994,266 (GRCm39)	missense	probably damaging	1.00
R1967:Vmn2r9	UTSW	5	108,995,388 (GRCm39)	missense	probably benign	0.03
R1991:Vmn2r9	UTSW	5	108,994,305 (GRCm39)	missense	probably damaging	0.99
R2410:Vmn2r9	UTSW	5	108,996,123 (GRCm39)	missense	probably damaging	1.00
R3419:Vmn2r9	UTSW	5	108,994,299 (GRCm39)	missense	probably damaging	0.96
R3852:Vmn2r9	UTSW	5	108,995,997 (GRCm39)	missense	probably damaging	1.00
R3873:Vmn2r9	UTSW	5	108,995,701 (GRCm39)	missense	probably benign	0.14
R3905:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3908:Vmn2r9	UTSW	5	108,995,785 (GRCm39)	missense	probably benign	0.37
R3921:Vmn2r9	UTSW	5	108,996,921 (GRCm39)	missense	probably benign
R4156:Vmn2r9	UTSW	5	108,995,743 (GRCm39)	missense	possibly damaging	0.64
R4477:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4478:Vmn2r9	UTSW	5	108,994,143 (GRCm39)	missense	probably benign
R4544:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4546:Vmn2r9	UTSW	5	108,995,551 (GRCm39)	missense	probably benign	0.00
R4627:Vmn2r9	UTSW	5	108,995,463 (GRCm39)	missense	probably damaging	1.00
R5215:Vmn2r9	UTSW	5	108,994,351 (GRCm39)	missense	probably benign	0.03
R5361:Vmn2r9	UTSW	5	108,995,929 (GRCm39)	missense	probably damaging	1.00
R5587:Vmn2r9	UTSW	5	108,995,427 (GRCm39)	missense	probably damaging	1.00
R6054:Vmn2r9	UTSW	5	108,996,126 (GRCm39)	missense	probably damaging	0.99
R6106:Vmn2r9	UTSW	5	108,992,902 (GRCm39)	missense	probably benign
R6125:Vmn2r9	UTSW	5	108,990,836 (GRCm39)	missense	probably benign	0.01
R6137:Vmn2r9	UTSW	5	108,996,882 (GRCm39)	missense	probably benign	0.00
R6920:Vmn2r9	UTSW	5	108,996,912 (GRCm39)	missense	possibly damaging	0.72
R7579:Vmn2r9	UTSW	5	108,992,948 (GRCm39)	missense	probably damaging	1.00
R8683:Vmn2r9	UTSW	5	108,996,873 (GRCm39)	missense	probably benign
R8964:Vmn2r9	UTSW	5	108,996,031 (GRCm39)	missense	probably benign	0.05
R9022:Vmn2r9	UTSW	5	108,992,923 (GRCm39)	missense	possibly damaging	0.90
R9118:Vmn2r9	UTSW	5	108,990,937 (GRCm39)	missense	probably damaging	0.99
R9125:Vmn2r9	UTSW	5	108,996,047 (GRCm39)	missense
R9240:Vmn2r9	UTSW	5	108,996,099 (GRCm39)	missense	possibly damaging	0.78
R9327:Vmn2r9	UTSW	5	108,996,841 (GRCm39)	missense	probably damaging	0.96
R9412:Vmn2r9	UTSW	5	108,991,484 (GRCm39)	missense	probably damaging	1.00
R9499:Vmn2r9	UTSW	5	108,995,584 (GRCm39)	missense	probably damaging	1.00
R9757:Vmn2r9	UTSW	5	108,995,908 (GRCm39)	missense	possibly damaging	0.87
R9790:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99
R9791:Vmn2r9	UTSW	5	108,995,409 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-12-18