Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02828:Or10g3b'

361294

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10g3b

Ensembl Gene

ENSMUSG00000095030

Gene Name

olfactory receptor family 10 subfamily G member 3B

Synonyms

GA_x6K02T2RJGY-644134-645075, Olfr1513, MOR223-10, MOR223-7P

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.107) question?

Stock #

IGL02828

Quality Score

Status

Chromosome

Chromosomal Location

52586560-52587501 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 52586799 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 235 (R235G)

Ref Sequence

ENSEMBL: ENSMUSP00000149216 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089739] [ENSMUST00000215147]

AlphaFold

L7N457

Predicted Effect

probably benign
Transcript: ENSMUST00000089739
AA Change: R235G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000087171
Gene: ENSMUSG00000095030
AA Change: R235G

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	5.2e-49	PFAM
Pfam:7tm_1	41	291	1.6e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215147
AA Change: R235G

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca8b	G	A	11: 109,871,720 (GRCm39)	T86I	probably damaging	Het
Adam28	C	T	14: 68,884,319 (GRCm39)	S93N	possibly damaging	Het
Adamts6	T	C	13: 104,433,978 (GRCm39)	Y136H	probably damaging	Het
Ahdc1	A	T	4: 132,790,232 (GRCm39)	K491I	possibly damaging	Het
Alb	C	A	5: 90,615,247 (GRCm39)	A253E	probably benign	Het
Asb18	A	G	1: 89,923,932 (GRCm39)		probably null	Het
Asxl3	T	A	18: 22,657,718 (GRCm39)	N1909K	possibly damaging	Het
Atosa	G	T	9: 74,913,714 (GRCm39)	A123S	probably damaging	Het
Atp12a	T	A	14: 56,613,599 (GRCm39)	V457D	possibly damaging	Het
Atxn7	G	T	14: 14,090,056 (GRCm38)	G334W	probably damaging	Het
Catsperb	T	A	12: 101,447,041 (GRCm39)	I223K	probably benign	Het
Clec2h	T	A	6: 128,652,885 (GRCm39)	H217Q	probably benign	Het
Col6a3	T	C	1: 90,724,281 (GRCm39)	E1416G	probably damaging	Het
Dcaf1	T	A	9: 106,721,501 (GRCm39)		probably benign	Het
Ddr2	C	T	1: 169,816,082 (GRCm39)	A542T	probably benign	Het
Ebf3	T	C	7: 136,909,247 (GRCm39)	N174S	probably damaging	Het
Ecpas	A	G	4: 58,875,512 (GRCm39)	S151P	possibly damaging	Het
Ephb2	A	G	4: 136,498,461 (GRCm39)	I206T	probably benign	Het
Fbxo39	T	A	11: 72,208,041 (GRCm39)	I131N	possibly damaging	Het
Fdxacb1	G	A	9: 50,682,864 (GRCm39)	V276I	possibly damaging	Het
Gpr146	A	T	5: 139,378,576 (GRCm39)	Y126F	probably damaging	Het
Hivep3	A	T	4: 119,954,929 (GRCm39)	K1082*	probably null	Het
Ifnar1	T	A	16: 91,302,304 (GRCm39)		probably null	Het
Kap	A	G	6: 133,829,057 (GRCm39)	V25A	probably benign	Het
Klhl2	C	A	8: 65,232,791 (GRCm39)	R162L	probably damaging	Het
Kmt2a	A	G	9: 44,733,244 (GRCm39)		probably benign	Het
Lrp4	A	G	2: 91,305,639 (GRCm39)	N303S	probably benign	Het
Mtpap	A	T	18: 4,386,207 (GRCm39)	N276Y	probably damaging	Het
Nlrp5	G	A	7: 23,120,885 (GRCm39)	G684S	possibly damaging	Het
Or14a256	A	T	7: 86,265,277 (GRCm39)	V192E	possibly damaging	Het
Pak2	A	T	16: 31,840,674 (GRCm39)	L469H	probably damaging	Het
Pcdhb15	T	A	18: 37,606,903 (GRCm39)	L45Q	probably damaging	Het
Pi4ka	A	T	16: 17,098,575 (GRCm39)		probably benign	Het
Picalm	A	G	7: 89,826,709 (GRCm39)	T386A	probably benign	Het
Pkd1l2	T	C	8: 117,756,298 (GRCm39)	T1645A	probably benign	Het
Plekhm2	A	T	4: 141,356,941 (GRCm39)	V754E	probably damaging	Het
Pramel25	A	T	4: 143,521,695 (GRCm39)	D437V	possibly damaging	Het
Rbl1	T	A	2: 157,041,384 (GRCm39)	E81V	probably damaging	Het
Rbp4	C	A	19: 38,106,717 (GRCm39)		probably null	Het
Rdh12	T	C	12: 79,265,459 (GRCm39)	V211A	probably damaging	Het
Ret	G	A	6: 118,153,168 (GRCm39)	A500V	probably benign	Het
Rin1	T	C	19: 5,103,118 (GRCm39)	F469S	possibly damaging	Het
Rmc1	C	A	18: 12,322,278 (GRCm39)	A577D	possibly damaging	Het
Rsc1a1	G	T	4: 141,411,479 (GRCm39)	P478T	probably damaging	Het
Setd2	A	T	9: 110,390,282 (GRCm39)	Y1579F	probably benign	Het
Sh3bp5	A	T	14: 31,156,106 (GRCm39)		probably benign	Het
Slc22a13	G	T	9: 119,024,773 (GRCm39)	L235I	probably benign	Het
Slc6a11	A	T	6: 114,111,948 (GRCm39)	T172S	possibly damaging	Het
Slitrk1	G	T	14: 109,149,048 (GRCm39)	S554R	possibly damaging	Het
Tg	G	A	15: 66,554,243 (GRCm39)	G553S	probably damaging	Het
Tmem26	G	A	10: 68,611,215 (GRCm39)		probably null	Het
Trpm2	A	T	10: 77,754,820 (GRCm39)	L1222Q	probably benign	Het
Vdac2	T	C	14: 21,893,957 (GRCm39)	V249A	probably benign	Het
Vmn1r170	T	C	7: 23,305,943 (GRCm39)	V115A	probably damaging	Het
Vmn2r105	A	G	17: 20,429,345 (GRCm39)	V577A	possibly damaging	Het
Xpo1	A	G	11: 23,232,593 (GRCm39)	E371G	probably damaging	Het
Zfp106	A	C	2: 120,362,178 (GRCm39)	H980Q	possibly damaging	Het

Other mutations in Or10g3b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00309:Or10g3b	APN	14	52,587,167 (GRCm39)	missense	probably benign	0.00
IGL02485:Or10g3b	APN	14	52,587,501 (GRCm39)	start codon destroyed	possibly damaging	0.89
R0744:Or10g3b	UTSW	14	52,586,835 (GRCm39)	missense	probably benign	0.00
R0833:Or10g3b	UTSW	14	52,586,835 (GRCm39)	missense	probably benign	0.00
R2316:Or10g3b	UTSW	14	52,587,395 (GRCm39)	missense	probably benign	0.00
R4898:Or10g3b	UTSW	14	52,586,999 (GRCm39)	missense	probably damaging	1.00
R5018:Or10g3b	UTSW	14	52,586,736 (GRCm39)	missense	possibly damaging	0.81
R5134:Or10g3b	UTSW	14	52,587,248 (GRCm39)	missense	probably benign	0.03
R5485:Or10g3b	UTSW	14	52,586,776 (GRCm39)	nonsense	probably null
R6819:Or10g3b	UTSW	14	52,587,156 (GRCm39)	missense	probably damaging	1.00
R6877:Or10g3b	UTSW	14	52,587,270 (GRCm39)	missense	possibly damaging	0.95
R7583:Or10g3b	UTSW	14	52,587,360 (GRCm39)	missense	possibly damaging	0.93
R7606:Or10g3b	UTSW	14	52,587,420 (GRCm39)	missense	probably benign	0.33
R7653:Or10g3b	UTSW	14	52,586,889 (GRCm39)	nonsense	probably null
R8111:Or10g3b	UTSW	14	52,587,344 (GRCm39)	missense	possibly damaging	0.70
R8262:Or10g3b	UTSW	14	52,586,625 (GRCm39)	missense	probably damaging	1.00
R8487:Or10g3b	UTSW	14	52,586,696 (GRCm39)	missense	probably damaging	1.00
R8786:Or10g3b	UTSW	14	52,587,021 (GRCm39)	missense	possibly damaging	0.74
R9003:Or10g3b	UTSW	14	52,586,768 (GRCm39)	missense	probably damaging	1.00
R9507:Or10g3b	UTSW	14	52,586,678 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18