Incidental Mutation 'R5082:Ccng1'
ID 387206
Institutional Source Beutler Lab
Gene Symbol Ccng1
Ensembl Gene ENSMUSG00000020326
Gene Name cyclin G1
Synonyms cyclin G
MMRRC Submission 042671-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # R5082 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 40639379-40646044 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 40643015 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 144 (V144A)
Ref Sequence ENSEMBL: ENSMUSP00000020576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020576]
AlphaFold P51945
Predicted Effect possibly damaging
Transcript: ENSMUST00000020576
AA Change: V144A

PolyPhen 2 Score 0.767 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000020576
Gene: ENSMUSG00000020326
AA Change: V144A

DomainStartEndE-ValueType
CYCLIN 56 142 3.63e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151359
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Depending on the allele, homozygous mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(4)

Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T A 11: 110,022,694 (GRCm39) M1015L probably benign Het
Aftph T C 11: 20,677,100 (GRCm39) S170G probably damaging Het
Aox4 C T 1: 58,270,642 (GRCm39) P274S possibly damaging Het
Ash1l G A 3: 88,873,541 (GRCm39) R108Q probably damaging Het
Aspm T A 1: 139,406,414 (GRCm39) L1767* probably null Het
Baz2b T A 2: 59,731,835 (GRCm39) K2068* probably null Het
Bcl9 A T 3: 97,117,218 (GRCm39) V492D probably damaging Het
Bicc1 G T 10: 70,776,352 (GRCm39) H782Q probably benign Het
Cabin1 T A 10: 75,574,164 (GRCm39) I640F probably damaging Het
Cdc23 C A 18: 34,784,742 (GRCm39) V7L unknown Het
Ddx1 G T 12: 13,270,436 (GRCm39) C668* probably null Het
Dhx58 G A 11: 100,587,802 (GRCm39) S585L probably benign Het
Dnttip2 A T 3: 122,069,590 (GRCm39) K268N probably damaging Het
Ecd C T 14: 20,374,436 (GRCm39) probably null Het
Entpd1 A G 19: 40,713,473 (GRCm39) probably null Het
Erlin2 T C 8: 27,523,435 (GRCm39) V224A probably damaging Het
Exoc3l4 A G 12: 111,394,424 (GRCm39) S515G probably benign Het
Fcho1 T C 8: 72,169,829 (GRCm39) D98G possibly damaging Het
Fhod1 T A 8: 106,057,145 (GRCm39) D943V probably damaging Het
Gm10322 A T 10: 59,452,090 (GRCm39) E69V possibly damaging Het
Gm14295 T A 2: 176,499,210 (GRCm39) L19* probably null Het
Gm7347 T A 5: 26,262,372 (GRCm39) R50* probably null Het
Hesx1 T C 14: 26,722,731 (GRCm39) C19R probably benign Het
Hgh1 T A 15: 76,253,752 (GRCm39) F199L probably benign Het
Irak2 T C 6: 113,649,805 (GRCm39) F147L probably damaging Het
Kif22 G A 7: 126,632,549 (GRCm39) R254C possibly damaging Het
Klhl9 A T 4: 88,639,622 (GRCm39) S206R probably damaging Het
Maip1 T C 1: 57,451,010 (GRCm39) probably null Het
Mcm9 T A 10: 53,414,156 (GRCm39) E308V possibly damaging Het
Mfsd13b A T 7: 120,598,201 (GRCm39) N369I possibly damaging Het
Mga T A 2: 119,733,825 (GRCm39) H224Q probably damaging Het
Mtss1 A T 15: 58,842,868 (GRCm39) W115R probably damaging Het
Myo3b T C 2: 70,088,374 (GRCm39) V851A probably benign Het
Nectin2 A T 7: 19,472,049 (GRCm39) D113E probably damaging Het
Notch2 G A 3: 98,007,690 (GRCm39) C480Y probably damaging Het
Or6b6 G A 7: 106,570,871 (GRCm39) R227C probably benign Het
Or8b55 T C 9: 38,727,441 (GRCm39) I214T possibly damaging Het
Pfdn1 G T 18: 36,537,466 (GRCm39) N111K probably damaging Het
Pfkl A T 10: 77,832,242 (GRCm39) V283E probably damaging Het
Plbd2 G T 5: 120,629,249 (GRCm39) S305* probably null Het
Prom1 T C 5: 44,158,174 (GRCm39) probably null Het
Ptbp2 T A 3: 119,546,613 (GRCm39) M90L probably benign Het
Rai1 G A 11: 60,076,745 (GRCm39) E270K possibly damaging Het
Rbbp6 G A 7: 122,599,925 (GRCm39) probably benign Het
Reln T C 5: 22,101,075 (GRCm39) M3399V probably benign Het
Ros1 T A 10: 52,040,037 (GRCm39) Y318F possibly damaging Het
Sh2d2a A G 3: 87,759,091 (GRCm39) D231G probably benign Het
Smn1 T C 13: 100,273,890 (GRCm39) probably benign Het
Snrnp200 C T 2: 127,068,290 (GRCm39) Q877* probably null Het
Taf2 G T 15: 54,923,441 (GRCm39) H279N probably benign Het
Tnfaip3 T C 10: 18,881,032 (GRCm39) Y345C probably damaging Het
Vmn2r68 C T 7: 84,883,076 (GRCm39) M225I probably benign Het
Vps13a A T 19: 16,722,257 (GRCm39) W352R probably damaging Het
Other mutations in Ccng1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Ccng1 APN 11 40,644,885 (GRCm39) missense probably benign 0.00
IGL01875:Ccng1 APN 11 40,643,183 (GRCm39) missense probably benign 0.09
IGL02986:Ccng1 APN 11 40,641,690 (GRCm39) utr 3 prime probably benign
G5030:Ccng1 UTSW 11 40,644,629 (GRCm39) splice site probably benign
R1375:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1377:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1715:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R3620:Ccng1 UTSW 11 40,642,992 (GRCm39) missense probably benign 0.01
R3857:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R3858:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R5172:Ccng1 UTSW 11 40,642,113 (GRCm39) missense probably benign
R5521:Ccng1 UTSW 11 40,643,093 (GRCm39) missense possibly damaging 0.87
R7431:Ccng1 UTSW 11 40,644,745 (GRCm39) missense possibly damaging 0.74
R7961:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8009:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8794:Ccng1 UTSW 11 40,644,826 (GRCm39) missense probably benign
R9036:Ccng1 UTSW 11 40,643,078 (GRCm39) missense possibly damaging 0.55
R9530:Ccng1 UTSW 11 40,644,885 (GRCm39) missense probably benign 0.00
T0975:Ccng1 UTSW 11 40,644,871 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GACTGGCAGGCATCTTTTCAC -3'
(R):5'- GCACTGTAAAGACACTGGTGTG -3'

Sequencing Primer
(F):5'- CACTTCTGTTAGGCAGCAAAG -3'
(R):5'- TGTTTGTAGGTACAGGCGAAG -3'
Posted On 2016-06-06