Incidental Mutation 'R5099:Tada2b'
ID 388170
Institutional Source Beutler Lab
Gene Symbol Tada2b
Ensembl Gene ENSMUSG00000029196
Gene Name transcriptional adaptor 2B
Synonyms LOC231151
MMRRC Submission 042688-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.963) question?
Stock # R5099 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 36631014-36641629 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 36633744 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 203 (M203K)
Ref Sequence ENSEMBL: ENSMUSP00000114124 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031097] [ENSMUST00000031099] [ENSMUST00000119916]
AlphaFold D3Z4Z0
Predicted Effect probably benign
Transcript: ENSMUST00000031097
AA Change: M278K

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000031097
Gene: ENSMUSG00000029196
AA Change: M278K

DomainStartEndE-ValueType
ZnF_ZZ 3 46 2.64e-5 SMART
SANT 66 116 1.75e-9 SMART
low complexity region 138 154 N/A INTRINSIC
low complexity region 233 260 N/A INTRINSIC
low complexity region 306 325 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000031099
SMART Domains Protein: ENSMUSP00000031099
Gene: ENSMUSG00000029198

DomainStartEndE-ValueType
low complexity region 7 21 N/A INTRINSIC
Pfam:GrpE 32 215 5.3e-45 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119916
AA Change: M203K

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000114124
Gene: ENSMUSG00000029196
AA Change: M203K

DomainStartEndE-ValueType
Blast:SANT 16 41 2e-10 BLAST
low complexity region 63 79 N/A INTRINSIC
low complexity region 158 185 N/A INTRINSIC
low complexity region 231 250 N/A INTRINSIC
Meta Mutation Damage Score 0.1580 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 98% (41/42)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arsa A G 15: 89,359,542 (GRCm39) L80P probably damaging Het
Bdkrb1 A G 12: 105,570,533 (GRCm39) D33G probably benign Het
Ccdc178 A T 18: 22,238,648 (GRCm39) V323E probably benign Het
Ceacam5 T C 7: 17,479,513 (GRCm39) V210A probably damaging Het
Dcdc2a A G 13: 25,291,681 (GRCm39) E222G probably benign Het
Gbp9 A T 5: 105,242,379 (GRCm39) L120Q probably damaging Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Gsr T A 8: 34,161,556 (GRCm39) I121N probably damaging Het
Ift140 T A 17: 25,309,674 (GRCm39) M1068K probably damaging Het
Jakmip2 A G 18: 43,701,173 (GRCm39) I414T probably benign Het
Lpin2 G A 17: 71,550,965 (GRCm39) W708* probably null Het
Mecom A G 3: 30,039,465 (GRCm39) probably benign Het
Mff C T 1: 82,728,192 (GRCm39) probably benign Het
Ms4a20 T C 19: 11,089,825 (GRCm39) probably null Het
Neb C T 2: 52,085,460 (GRCm39) C1545Y probably damaging Het
Or5ac24 C T 16: 59,165,266 (GRCm39) G266D probably benign Het
Or5p5 A G 7: 107,413,809 (GRCm39) H6R probably benign Het
Or8k36-ps1 A T 2: 86,437,560 (GRCm39) N118K unknown Het
Ppm1n A T 7: 19,011,903 (GRCm39) L392Q possibly damaging Het
Prr22 T C 17: 57,078,467 (GRCm39) F207L probably benign Het
Ptprv T C 1: 135,046,592 (GRCm39) noncoding transcript Het
Rin2 G A 2: 145,720,821 (GRCm39) C718Y probably damaging Het
Rpgrip1l G A 8: 91,975,350 (GRCm39) T1089I probably benign Het
Scn1a A G 2: 66,108,145 (GRCm39) V1510A probably damaging Het
Slfn3 A T 11: 83,105,764 (GRCm39) Y587F probably damaging Het
Sp2 T C 11: 96,852,175 (GRCm39) K250E probably damaging Het
Ssu2 A G 6: 112,336,585 (GRCm39) S333P probably benign Het
Strbp T C 2: 37,493,030 (GRCm39) T419A probably damaging Het
Tmem176b T C 6: 48,811,463 (GRCm39) Y62C probably benign Het
Tox G T 4: 6,688,958 (GRCm39) Q469K probably benign Het
Trgv5 G T 13: 19,376,886 (GRCm39) C111F probably damaging Het
Tyw5 T C 1: 57,427,864 (GRCm39) N243D probably damaging Het
Ube2q2 T A 9: 55,113,307 (GRCm39) probably benign Het
Ufl1 C T 4: 25,275,914 (GRCm39) R83Q probably damaging Het
Unk A G 11: 115,949,936 (GRCm39) Q701R probably benign Het
Vmn1r60 A T 7: 5,547,816 (GRCm39) C95S probably damaging Het
Vmn1r81 A G 7: 11,994,248 (GRCm39) I120T possibly damaging Het
Other mutations in Tada2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00530:Tada2b APN 5 36,633,417 (GRCm39) missense probably damaging 0.99
IGL01453:Tada2b APN 5 36,633,686 (GRCm39) missense probably damaging 1.00
R1654:Tada2b UTSW 5 36,641,139 (GRCm39) missense probably damaging 1.00
R2019:Tada2b UTSW 5 36,641,250 (GRCm39) missense probably damaging 1.00
R2337:Tada2b UTSW 5 36,634,258 (GRCm39) missense probably benign 0.17
R3765:Tada2b UTSW 5 36,633,761 (GRCm39) missense probably benign
R3766:Tada2b UTSW 5 36,633,761 (GRCm39) missense probably benign
R6154:Tada2b UTSW 5 36,634,008 (GRCm39) missense probably damaging 0.98
R6285:Tada2b UTSW 5 36,634,186 (GRCm39) missense probably damaging 1.00
R6483:Tada2b UTSW 5 36,634,029 (GRCm39) missense possibly damaging 0.74
R7265:Tada2b UTSW 5 36,633,952 (GRCm39) missense probably damaging 1.00
R7318:Tada2b UTSW 5 36,641,331 (GRCm39) missense probably benign
R7346:Tada2b UTSW 5 36,634,180 (GRCm39) missense possibly damaging 0.70
R7523:Tada2b UTSW 5 36,634,111 (GRCm39) missense probably benign 0.00
R7587:Tada2b UTSW 5 36,634,111 (GRCm39) missense probably benign 0.00
R8856:Tada2b UTSW 5 36,641,166 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TGCAAACTCGCTGTCTTTGC -3'
(R):5'- TGTAGACATGTATGTGCGGAAG -3'

Sequencing Primer
(F):5'- AAACTCGCTGTCTTTGCCATCC -3'
(R):5'- CGCCGGAAGAACATTGCCAG -3'
Posted On 2016-06-06