Incidental Mutation 'IGL03012:Vmn1r181'
| ID |
407798 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r181
|
| Ensembl Gene |
ENSMUSG00000097425 |
| Gene Name |
vomeronasal 1 receptor 181 |
| Synonyms |
V1rd20 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL03012
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
23683386-23684473 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 23684027 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 164
(D164V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154403
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000181796]
[ENSMUST00000226843]
[ENSMUST00000226978]
[ENSMUST00000227637]
[ENSMUST00000228399]
[ENSMUST00000228842]
|
| AlphaFold |
Q0P547 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000181796
AA Change: D164V
PolyPhen 2
Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000137685
Gene: ENSMUSG00000097425
AA Change: D164V
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
296 |
3.9e-9 |
PFAM |
|
Pfam:V1R
|
41 |
295 |
2.7e-13 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226843
AA Change: D164V
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000226978
AA Change: D164V
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000227637
AA Change: D164V
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228399
AA Change: D164V
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228531
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000228607
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228842
AA Change: D164V
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaa1b |
A |
C |
9: 118,986,014 (GRCm39) |
S17A |
probably benign |
Het |
| Acp1 |
T |
G |
12: 30,945,948 (GRCm39) |
N135T |
probably benign |
Het |
| Adamts2 |
A |
G |
11: 50,667,096 (GRCm39) |
|
probably benign |
Het |
| Arfgef2 |
C |
T |
2: 166,710,808 (GRCm39) |
|
probably benign |
Het |
| Atp10b |
T |
A |
11: 43,085,482 (GRCm39) |
I287N |
probably damaging |
Het |
| Camta1 |
T |
A |
4: 151,537,756 (GRCm39) |
K141N |
probably damaging |
Het |
| Carmil1 |
T |
C |
13: 24,220,355 (GRCm39) |
D719G |
probably benign |
Het |
| Cntnap5c |
T |
A |
17: 58,666,229 (GRCm39) |
H1086Q |
probably benign |
Het |
| Dsg3 |
A |
G |
18: 20,670,300 (GRCm39) |
|
probably null |
Het |
| Emilin3 |
G |
A |
2: 160,750,649 (GRCm39) |
Q320* |
probably null |
Het |
| G6pd2 |
A |
G |
5: 61,966,816 (GRCm39) |
Y197C |
probably damaging |
Het |
| Il13ra1 |
G |
T |
X: 35,394,247 (GRCm39) |
|
probably benign |
Het |
| Ivl |
G |
A |
3: 92,479,733 (GRCm39) |
P111S |
probably benign |
Het |
| Kmt2a |
T |
C |
9: 44,722,263 (GRCm39) |
|
probably benign |
Het |
| Lztr1 |
T |
C |
16: 17,339,348 (GRCm39) |
S57P |
possibly damaging |
Het |
| Mtss1 |
T |
G |
15: 58,930,249 (GRCm39) |
D32A |
probably damaging |
Het |
| Mylk |
G |
A |
16: 34,773,151 (GRCm39) |
D1250N |
probably benign |
Het |
| Ncln |
A |
G |
10: 81,325,799 (GRCm39) |
F349L |
probably benign |
Het |
| Pgap1 |
A |
G |
1: 54,572,572 (GRCm39) |
|
probably benign |
Het |
| Rarres2 |
T |
C |
6: 48,547,239 (GRCm39) |
D107G |
probably benign |
Het |
| Ric3 |
T |
C |
7: 108,637,925 (GRCm39) |
D276G |
probably benign |
Het |
| Trim54 |
A |
G |
5: 31,294,489 (GRCm39) |
D339G |
probably benign |
Het |
| Trip11 |
G |
A |
12: 101,850,195 (GRCm39) |
H1005Y |
probably damaging |
Het |
| Tulp4 |
G |
T |
17: 6,263,654 (GRCm39) |
|
probably benign |
Het |
| Unc93a |
C |
T |
17: 13,328,495 (GRCm39) |
E453K |
probably benign |
Het |
| Vmn1r78 |
T |
A |
7: 11,887,291 (GRCm39) |
S301T |
probably benign |
Het |
| Vmn1r85 |
T |
C |
7: 12,818,692 (GRCm39) |
N151D |
probably benign |
Het |
| Wnk2 |
T |
C |
13: 49,197,865 (GRCm39) |
K2008E |
probably damaging |
Het |
| Wrap73 |
A |
G |
4: 154,229,691 (GRCm39) |
|
probably benign |
Het |
| Zfp408 |
G |
A |
2: 91,478,153 (GRCm39) |
A41V |
probably benign |
Het |
| Zfp472 |
A |
G |
17: 33,196,545 (GRCm39) |
S207G |
probably benign |
Het |
|
| Other mutations in Vmn1r181 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01443:Vmn1r181
|
APN |
7 |
23,684,006 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02055:Vmn1r181
|
APN |
7 |
23,683,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02444:Vmn1r181
|
APN |
7 |
23,683,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03026:Vmn1r181
|
APN |
7 |
23,684,000 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0255:Vmn1r181
|
UTSW |
7 |
23,683,759 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1481:Vmn1r181
|
UTSW |
7 |
23,684,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2847:Vmn1r181
|
UTSW |
7 |
23,683,943 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2848:Vmn1r181
|
UTSW |
7 |
23,683,943 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2849:Vmn1r181
|
UTSW |
7 |
23,683,943 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3441:Vmn1r181
|
UTSW |
7 |
23,684,308 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3757:Vmn1r181
|
UTSW |
7 |
23,683,909 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3945:Vmn1r181
|
UTSW |
7 |
23,683,577 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3983:Vmn1r181
|
UTSW |
7 |
23,684,234 (GRCm39) |
missense |
probably benign |
0.23 |
|
R4780:Vmn1r181
|
UTSW |
7 |
23,684,008 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R4999:Vmn1r181
|
UTSW |
7 |
23,683,790 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5463:Vmn1r181
|
UTSW |
7 |
23,683,787 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5672:Vmn1r181
|
UTSW |
7 |
23,683,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6229:Vmn1r181
|
UTSW |
7 |
23,683,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6315:Vmn1r181
|
UTSW |
7 |
23,684,183 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6316:Vmn1r181
|
UTSW |
7 |
23,684,183 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6317:Vmn1r181
|
UTSW |
7 |
23,684,183 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6324:Vmn1r181
|
UTSW |
7 |
23,684,183 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6326:Vmn1r181
|
UTSW |
7 |
23,684,183 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6988:Vmn1r181
|
UTSW |
7 |
23,684,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7446:Vmn1r181
|
UTSW |
7 |
23,684,356 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7972:Vmn1r181
|
UTSW |
7 |
23,683,871 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8465:Vmn1r181
|
UTSW |
7 |
23,684,309 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9096:Vmn1r181
|
UTSW |
7 |
23,684,444 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9097:Vmn1r181
|
UTSW |
7 |
23,684,444 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0067:Vmn1r181
|
UTSW |
7 |
23,684,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation