Incidental Mutation 'IGL03195:Olfr225'
ID412779
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr225
Ensembl Gene ENSMUSG00000044061
Gene Nameolfactory receptor 225
SynonymsGA_x6K02T0073K-490-1545, MOR256-51
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.192) question?
Stock #IGL03195
Quality Score
Status
Chromosome11
Chromosomal Location59612966-59613882 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 59613803 bp
ZygosityHeterozygous
Amino Acid Change Valine to Methionine at position 280 (V280M)
Ref Sequence ENSEMBL: ENSMUSP00000051482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055276] [ENSMUST00000213169]
Predicted Effect probably damaging
Transcript: ENSMUST00000055276
AA Change: V280M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000051482
Gene: ENSMUSG00000044061
AA Change: V280M

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 6.6e-47 PFAM
Pfam:7tm_1 40 289 4.3e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213169
AA Change: V280M

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,853,607 D1086G possibly damaging Het
Ahcyl2 T C 6: 29,906,769 probably benign Het
Ankrd42 T A 7: 92,591,858 Q431L probably benign Het
Arhgap12 A T 18: 6,031,766 F592I probably damaging Het
Arhgef28 A G 13: 97,951,563 probably null Het
Boc A G 16: 44,492,821 F560S probably damaging Het
Ccdc81 A T 7: 89,896,708 V96E probably benign Het
Cep162 C T 9: 87,225,786 S517N probably benign Het
Cntnap5a A G 1: 116,157,448 N372S probably benign Het
Dnah7a G A 1: 53,419,607 R3791C probably damaging Het
Fdxr T C 11: 115,276,092 Q57R probably benign Het
G3bp2 A G 5: 92,068,508 probably benign Het
Gm595 T A X: 48,872,948 Q296L possibly damaging Het
Hmcn1 G A 1: 150,802,909 T487I probably benign Het
Kpna7 A T 5: 144,997,037 I282N probably damaging Het
Lif A T 11: 4,269,201 Y160F probably damaging Het
Lrp1b A T 2: 41,471,122 D556E possibly damaging Het
Myom2 G T 8: 15,111,844 E954* probably null Het
Nr6a1 A T 2: 38,742,936 I171N probably damaging Het
Nup210 C A 6: 91,015,850 R1059L probably benign Het
Olfr1109 A T 2: 87,092,569 V276E probably damaging Het
Olfr698 A G 7: 106,752,773 I205T probably benign Het
Olfr743 A G 14: 50,533,420 T3A probably benign Het
Olfr987 A T 2: 85,331,520 I126N probably damaging Het
Ostm1 T C 10: 42,698,217 V302A probably damaging Het
Oxct1 A G 15: 4,101,189 M388V possibly damaging Het
Ppp6r2 G A 15: 89,268,555 V300I possibly damaging Het
Prmt1 T C 7: 44,977,571 Y205C probably damaging Het
Slc45a4 A C 15: 73,584,423 V636G possibly damaging Het
Spata18 T A 5: 73,671,248 L270Q probably damaging Het
Stard9 G A 2: 120,705,802 D4151N probably damaging Het
Thsd7b G A 1: 129,628,909 C334Y probably damaging Het
Tmtc3 C T 10: 100,459,034 V406M probably benign Het
Trpc5 T A X: 144,382,728 M900L probably benign Het
Ttc9c T C 19: 8,815,980 K99E probably benign Het
Vmn1r73 A G 7: 11,757,080 E275G probably damaging Het
Other mutations in Olfr225
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00090:Olfr225 APN 11 59613321 missense possibly damaging 0.86
IGL01835:Olfr225 APN 11 59613339 missense probably damaging 0.99
IGL02006:Olfr225 APN 11 59613159 missense probably damaging 1.00
R0148:Olfr225 UTSW 11 59613494 missense probably damaging 1.00
R0831:Olfr225 UTSW 11 59613654 missense possibly damaging 0.70
R1924:Olfr225 UTSW 11 59613123 missense possibly damaging 0.58
R2184:Olfr225 UTSW 11 59613138 missense probably damaging 1.00
R5772:Olfr225 UTSW 11 59613886 missense probably benign
R6986:Olfr225 UTSW 11 59614098 missense possibly damaging 0.53
Posted On2016-08-02