Incidental Mutation 'IGL03223:Zfp658'
| ID |
413705 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp658
|
| Ensembl Gene |
ENSMUSG00000056592 |
| Gene Name |
zinc finger protein 658 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03223
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
43211680-43224885 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 43216735 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 35
(E35G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103606
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005597]
[ENSMUST00000107972]
|
| AlphaFold |
Q5PPQ4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000005597
AA Change: E35G
PolyPhen 2
Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000005597
Gene: ENSMUSG00000056592
AA Change: E35G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
23 |
83 |
3.7e-27 |
SMART |
|
ZnF_C2H2
|
276 |
295 |
8.84e1 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
5.81e-2 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
524 |
546 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
552 |
574 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
580 |
602 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
608 |
630 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
636 |
658 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
664 |
686 |
3.74e-5 |
SMART |
|
ZnF_C2H2
|
692 |
714 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
720 |
742 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
748 |
770 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
776 |
798 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
804 |
826 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
832 |
854 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
860 |
882 |
5.81e-2 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107972
AA Change: E35G
PolyPhen 2
Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000103606
Gene: ENSMUSG00000056592
AA Change: E35G
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
23 |
83 |
3.7e-27 |
SMART |
|
ZnF_C2H2
|
276 |
295 |
8.84e1 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
5.81e-2 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
524 |
546 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
552 |
574 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
580 |
602 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
608 |
630 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
636 |
658 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
664 |
686 |
3.74e-5 |
SMART |
|
ZnF_C2H2
|
692 |
714 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
720 |
742 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
748 |
770 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
776 |
798 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
804 |
826 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
832 |
854 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
860 |
882 |
5.81e-2 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh3b1 |
T |
A |
19: 3,965,329 (GRCm39) |
H394L |
probably damaging |
Het |
| B430306N03Rik |
G |
A |
17: 48,623,896 (GRCm39) |
V66I |
probably damaging |
Het |
| Btbd10 |
T |
C |
7: 112,931,877 (GRCm39) |
N175S |
probably damaging |
Het |
| Dock4 |
C |
A |
12: 40,867,593 (GRCm39) |
Q1390K |
probably damaging |
Het |
| Eea1 |
A |
C |
10: 95,875,473 (GRCm39) |
E1248A |
probably damaging |
Het |
| Farp2 |
T |
A |
1: 93,545,324 (GRCm39) |
Y827* |
probably null |
Het |
| Gcc2 |
A |
G |
10: 58,134,556 (GRCm39) |
Y1510C |
probably damaging |
Het |
| Igfbp7 |
A |
C |
5: 77,497,318 (GRCm39) |
|
probably benign |
Het |
| Il1rapl1 |
A |
C |
X: 86,344,341 (GRCm39) |
C185G |
probably damaging |
Het |
| Itga7 |
A |
G |
10: 128,784,680 (GRCm39) |
|
probably benign |
Het |
| Itsn1 |
T |
C |
16: 91,702,194 (GRCm39) |
V12A |
probably benign |
Het |
| Lrrc4 |
A |
T |
6: 28,831,469 (GRCm39) |
C49S |
probably damaging |
Het |
| Lrrc49 |
T |
A |
9: 60,595,128 (GRCm39) |
K5N |
possibly damaging |
Het |
| Myh13 |
T |
C |
11: 67,241,068 (GRCm39) |
I815T |
probably benign |
Het |
| Myh8 |
T |
C |
11: 67,174,644 (GRCm39) |
I253T |
probably damaging |
Het |
| Myo19 |
A |
G |
11: 84,801,297 (GRCm39) |
T948A |
possibly damaging |
Het |
| Nhs |
T |
A |
X: 160,624,902 (GRCm39) |
I837F |
probably damaging |
Het |
| Or5b113 |
G |
T |
19: 13,342,645 (GRCm39) |
V218L |
probably benign |
Het |
| Or5b98 |
T |
C |
19: 12,931,268 (GRCm39) |
V105A |
probably benign |
Het |
| Pfpl |
A |
T |
19: 12,407,438 (GRCm39) |
Q563L |
probably damaging |
Het |
| Swt1 |
A |
G |
1: 151,255,170 (GRCm39) |
M809T |
possibly damaging |
Het |
| Tbc1d13 |
T |
A |
2: 30,038,648 (GRCm39) |
I311N |
probably damaging |
Het |
| Tgs1 |
T |
C |
4: 3,591,322 (GRCm39) |
|
probably benign |
Het |
| Usf3 |
C |
T |
16: 44,036,813 (GRCm39) |
T431M |
probably damaging |
Het |
| Vdac1 |
G |
A |
11: 52,267,482 (GRCm39) |
R93H |
probably benign |
Het |
| Vmn1r234 |
G |
A |
17: 21,449,653 (GRCm39) |
G189D |
probably damaging |
Het |
| Zfp14 |
A |
G |
7: 29,737,858 (GRCm39) |
Y376H |
probably damaging |
Het |
| Zfp472 |
T |
C |
17: 33,196,248 (GRCm39) |
C108R |
probably benign |
Het |
|
| Other mutations in Zfp658 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00465:Zfp658
|
APN |
7 |
43,216,780 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00475:Zfp658
|
APN |
7 |
43,223,500 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL01972:Zfp658
|
APN |
7 |
43,222,134 (GRCm39) |
nonsense |
probably null |
|
|
R0135:Zfp658
|
UTSW |
7 |
43,223,019 (GRCm39) |
nonsense |
probably null |
|
|
R1863:Zfp658
|
UTSW |
7 |
43,223,323 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1962:Zfp658
|
UTSW |
7 |
43,223,245 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2698:Zfp658
|
UTSW |
7 |
43,222,969 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3781:Zfp658
|
UTSW |
7 |
43,223,270 (GRCm39) |
missense |
probably benign |
|
|
R4791:Zfp658
|
UTSW |
7 |
43,223,890 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5392:Zfp658
|
UTSW |
7 |
43,222,355 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6092:Zfp658
|
UTSW |
7 |
43,223,951 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6594:Zfp658
|
UTSW |
7 |
43,216,701 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7003:Zfp658
|
UTSW |
7 |
43,224,172 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7008:Zfp658
|
UTSW |
7 |
43,223,336 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7077:Zfp658
|
UTSW |
7 |
43,223,413 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7689:Zfp658
|
UTSW |
7 |
43,224,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7793:Zfp658
|
UTSW |
7 |
43,224,108 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7939:Zfp658
|
UTSW |
7 |
43,224,301 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8672:Zfp658
|
UTSW |
7 |
43,222,919 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8828:Zfp658
|
UTSW |
7 |
43,222,240 (GRCm39) |
missense |
probably benign |
|
|
R8995:Zfp658
|
UTSW |
7 |
43,222,798 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9021:Zfp658
|
UTSW |
7 |
43,223,381 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9259:Zfp658
|
UTSW |
7 |
43,224,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9551:Zfp658
|
UTSW |
7 |
43,222,567 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9552:Zfp658
|
UTSW |
7 |
43,222,567 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9571:Zfp658
|
UTSW |
7 |
43,222,139 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Zfp658
|
UTSW |
7 |
43,222,641 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
| Posted On |
2016-08-02 |
Incidental Mutation