Incidental Mutation 'IGL01972:Zfp658'
| ID |
181665 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp658
|
| Ensembl Gene |
ENSMUSG00000056592 |
| Gene Name |
zinc finger protein 658 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01972
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
43211680-43224885 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 43222134 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Stop codon
at position 136
(W136*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000103606
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005597]
[ENSMUST00000107972]
|
| AlphaFold |
Q5PPQ4 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000005597
AA Change: W136*
|
| SMART Domains |
Protein: ENSMUSP00000005597
Gene: ENSMUSG00000056592
AA Change: W136*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
23 |
83 |
3.7e-27 |
SMART |
|
ZnF_C2H2
|
276 |
295 |
8.84e1 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
5.81e-2 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
524 |
546 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
552 |
574 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
580 |
602 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
608 |
630 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
636 |
658 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
664 |
686 |
3.74e-5 |
SMART |
|
ZnF_C2H2
|
692 |
714 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
720 |
742 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
748 |
770 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
776 |
798 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
804 |
826 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
832 |
854 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
860 |
882 |
5.81e-2 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000107972
AA Change: W136*
|
| SMART Domains |
Protein: ENSMUSP00000103606
Gene: ENSMUSG00000056592
AA Change: W136*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
23 |
83 |
3.7e-27 |
SMART |
|
ZnF_C2H2
|
276 |
295 |
8.84e1 |
SMART |
|
ZnF_C2H2
|
301 |
323 |
5.81e-2 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
6.88e-4 |
SMART |
|
ZnF_C2H2
|
524 |
546 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
552 |
574 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
580 |
602 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
608 |
630 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
636 |
658 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
664 |
686 |
3.74e-5 |
SMART |
|
ZnF_C2H2
|
692 |
714 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
720 |
742 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
748 |
770 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
776 |
798 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
804 |
826 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
832 |
854 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
860 |
882 |
5.81e-2 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ahr |
T |
G |
12: 35,554,448 (GRCm39) |
D557A |
possibly damaging |
Het |
| Akap11 |
T |
C |
14: 78,745,297 (GRCm39) |
Q1697R |
probably damaging |
Het |
| Alpi |
T |
A |
1: 87,027,431 (GRCm39) |
T312S |
probably damaging |
Het |
| Cacna1b |
C |
A |
2: 24,525,107 (GRCm39) |
|
probably null |
Het |
| Car5a |
C |
T |
8: 122,653,821 (GRCm39) |
|
probably null |
Het |
| Cubn |
T |
C |
2: 13,450,883 (GRCm39) |
T841A |
possibly damaging |
Het |
| Eml6 |
A |
T |
11: 29,788,451 (GRCm39) |
F545I |
possibly damaging |
Het |
| Fam114a2 |
G |
A |
11: 57,400,220 (GRCm39) |
T156I |
probably damaging |
Het |
| Fbxl21 |
C |
T |
13: 56,684,672 (GRCm39) |
R259* |
probably null |
Het |
| Fhip1b |
T |
C |
7: 105,039,352 (GRCm39) |
N5S |
probably damaging |
Het |
| Gm5117 |
C |
T |
8: 32,227,787 (GRCm39) |
|
noncoding transcript |
Het |
| Hc |
T |
C |
2: 34,873,784 (GRCm39) |
Y1650C |
probably damaging |
Het |
| Med12l |
C |
A |
3: 59,169,314 (GRCm39) |
T1568K |
probably damaging |
Het |
| Mtrex |
T |
C |
13: 113,017,595 (GRCm39) |
K853E |
probably damaging |
Het |
| Or2ag2b |
A |
G |
7: 106,417,739 (GRCm39) |
I150V |
probably benign |
Het |
| Or5g27 |
T |
C |
2: 85,410,117 (GRCm39) |
F178S |
probably damaging |
Het |
| Or6n1 |
G |
T |
1: 173,916,987 (GRCm39) |
C127F |
probably damaging |
Het |
| Orm3 |
A |
G |
4: 63,277,563 (GRCm39) |
S184G |
probably benign |
Het |
| Padi1 |
A |
G |
4: 140,546,170 (GRCm39) |
|
probably benign |
Het |
| Rnf133 |
T |
C |
6: 23,648,988 (GRCm39) |
T357A |
probably benign |
Het |
| Tmem17 |
A |
G |
11: 22,467,265 (GRCm39) |
S60G |
probably benign |
Het |
| Ubqlnl |
G |
T |
7: 103,798,904 (GRCm39) |
Q198K |
probably benign |
Het |
| Vmn1r69 |
A |
T |
7: 10,314,586 (GRCm39) |
Y48* |
probably null |
Het |
|
| Other mutations in Zfp658 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00465:Zfp658
|
APN |
7 |
43,216,780 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00475:Zfp658
|
APN |
7 |
43,223,500 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL03223:Zfp658
|
APN |
7 |
43,216,735 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0135:Zfp658
|
UTSW |
7 |
43,223,019 (GRCm39) |
nonsense |
probably null |
|
|
R1863:Zfp658
|
UTSW |
7 |
43,223,323 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1962:Zfp658
|
UTSW |
7 |
43,223,245 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2698:Zfp658
|
UTSW |
7 |
43,222,969 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3781:Zfp658
|
UTSW |
7 |
43,223,270 (GRCm39) |
missense |
probably benign |
|
|
R4791:Zfp658
|
UTSW |
7 |
43,223,890 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5392:Zfp658
|
UTSW |
7 |
43,222,355 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6092:Zfp658
|
UTSW |
7 |
43,223,951 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6594:Zfp658
|
UTSW |
7 |
43,216,701 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7003:Zfp658
|
UTSW |
7 |
43,224,172 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7008:Zfp658
|
UTSW |
7 |
43,223,336 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7077:Zfp658
|
UTSW |
7 |
43,223,413 (GRCm39) |
missense |
probably benign |
0.32 |
|
R7689:Zfp658
|
UTSW |
7 |
43,224,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7793:Zfp658
|
UTSW |
7 |
43,224,108 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7939:Zfp658
|
UTSW |
7 |
43,224,301 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8672:Zfp658
|
UTSW |
7 |
43,222,919 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8828:Zfp658
|
UTSW |
7 |
43,222,240 (GRCm39) |
missense |
probably benign |
|
|
R8995:Zfp658
|
UTSW |
7 |
43,222,798 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9021:Zfp658
|
UTSW |
7 |
43,223,381 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9259:Zfp658
|
UTSW |
7 |
43,224,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9551:Zfp658
|
UTSW |
7 |
43,222,567 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9552:Zfp658
|
UTSW |
7 |
43,222,567 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9571:Zfp658
|
UTSW |
7 |
43,222,139 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1176:Zfp658
|
UTSW |
7 |
43,222,641 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
| Posted On |
2014-05-07 |
Incidental Mutation