Incidental Mutation 'IGL03228:Cdk15'
ID |
413794 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Cdk15
|
Ensembl Gene |
ENSMUSG00000026023 |
Gene Name |
cyclin dependent kinase 15 |
Synonyms |
Pftk2, Als2cr7 |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL03228
|
Quality Score |
|
Status
|
|
Chromosome |
1 |
Chromosomal Location |
59296029-59391656 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to T
at 59297912 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Asparagine
at position 106
(K106N)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000109886
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114248]
[ENSMUST00000160662]
|
AlphaFold |
Q3V3A1 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000114248
AA Change: K106N
PolyPhen 2
Score 0.949 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000109886 Gene: ENSMUSG00000026023 AA Change: K106N
Domain | Start | End | E-Value | Type |
S_TKc
|
101 |
385 |
7.9e-86 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000160662
AA Change: K108N
PolyPhen 2
Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000124680 Gene: ENSMUSG00000026023 AA Change: K108N
Domain | Start | End | E-Value | Type |
S_TKc
|
103 |
387 |
7.9e-86 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162487
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 23 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arid3a |
G |
A |
10: 79,786,578 (GRCm39) |
V444I |
possibly damaging |
Het |
Catsperg2 |
T |
C |
7: 29,397,650 (GRCm39) |
Y1021C |
probably damaging |
Het |
Cbx1 |
A |
G |
11: 96,691,631 (GRCm39) |
|
probably benign |
Het |
Itpkb |
A |
T |
1: 180,241,564 (GRCm39) |
R745W |
probably damaging |
Het |
Kdr |
T |
A |
5: 76,117,708 (GRCm39) |
I682F |
probably damaging |
Het |
Klhl1 |
T |
A |
14: 96,477,763 (GRCm39) |
E435V |
probably damaging |
Het |
Lamp3 |
T |
A |
16: 19,494,817 (GRCm39) |
Y296F |
possibly damaging |
Het |
Ltb4r2 |
A |
T |
14: 55,999,408 (GRCm39) |
N10Y |
probably damaging |
Het |
Mmrn1 |
C |
T |
6: 60,921,876 (GRCm39) |
P111L |
probably benign |
Het |
Nt5c |
A |
G |
11: 115,381,987 (GRCm39) |
Y107H |
probably damaging |
Het |
Or2m12 |
A |
C |
16: 19,105,140 (GRCm39) |
L118V |
probably damaging |
Het |
Or5p53 |
T |
A |
7: 107,533,330 (GRCm39) |
I201N |
possibly damaging |
Het |
Or8h9 |
A |
G |
2: 86,789,050 (GRCm39) |
F251L |
probably benign |
Het |
Piezo2 |
T |
A |
18: 63,186,133 (GRCm39) |
S1679C |
probably damaging |
Het |
Plac8l1 |
T |
A |
18: 42,325,672 (GRCm39) |
S78C |
probably damaging |
Het |
Scyl2 |
A |
T |
10: 89,485,942 (GRCm39) |
I549N |
probably damaging |
Het |
Slc51a |
G |
A |
16: 32,297,568 (GRCm39) |
R110C |
probably damaging |
Het |
Slc6a20b |
G |
T |
9: 123,461,197 (GRCm39) |
Y65* |
probably null |
Het |
Stx11 |
G |
A |
10: 12,816,956 (GRCm39) |
T256M |
probably benign |
Het |
Syne2 |
T |
C |
12: 76,026,686 (GRCm39) |
C3505R |
probably benign |
Het |
Trim75 |
A |
G |
8: 65,436,006 (GRCm39) |
L148P |
probably benign |
Het |
Ubr4 |
T |
A |
4: 139,156,909 (GRCm39) |
N2311K |
probably damaging |
Het |
Zfp553 |
A |
G |
7: 126,835,249 (GRCm39) |
H268R |
probably damaging |
Het |
|
Other mutations in Cdk15 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01307:Cdk15
|
APN |
1 |
59,326,955 (GRCm39) |
missense |
probably benign |
0.37 |
IGL01612:Cdk15
|
APN |
1 |
59,328,932 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL02179:Cdk15
|
APN |
1 |
59,370,100 (GRCm39) |
missense |
possibly damaging |
0.84 |
FR4449:Cdk15
|
UTSW |
1 |
59,296,982 (GRCm39) |
small insertion |
probably benign |
|
R0270:Cdk15
|
UTSW |
1 |
59,349,965 (GRCm39) |
missense |
probably damaging |
0.99 |
R1720:Cdk15
|
UTSW |
1 |
59,328,917 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Cdk15
|
UTSW |
1 |
59,383,475 (GRCm39) |
missense |
probably damaging |
0.99 |
R1969:Cdk15
|
UTSW |
1 |
59,370,110 (GRCm39) |
missense |
probably damaging |
1.00 |
R3159:Cdk15
|
UTSW |
1 |
59,340,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R6000:Cdk15
|
UTSW |
1 |
59,328,818 (GRCm39) |
missense |
probably damaging |
1.00 |
R6226:Cdk15
|
UTSW |
1 |
59,304,792 (GRCm39) |
missense |
probably damaging |
1.00 |
R6257:Cdk15
|
UTSW |
1 |
59,296,264 (GRCm39) |
critical splice donor site |
probably null |
|
R7184:Cdk15
|
UTSW |
1 |
59,304,814 (GRCm39) |
missense |
probably benign |
0.33 |
R7446:Cdk15
|
UTSW |
1 |
59,328,854 (GRCm39) |
missense |
probably damaging |
1.00 |
R7467:Cdk15
|
UTSW |
1 |
59,328,938 (GRCm39) |
missense |
probably null |
0.96 |
R7588:Cdk15
|
UTSW |
1 |
59,383,458 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8540:Cdk15
|
UTSW |
1 |
59,349,992 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9024:Cdk15
|
UTSW |
1 |
59,326,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R9372:Cdk15
|
UTSW |
1 |
59,370,142 (GRCm39) |
missense |
probably benign |
0.00 |
R9404:Cdk15
|
UTSW |
1 |
59,328,914 (GRCm39) |
missense |
possibly damaging |
0.55 |
R9493:Cdk15
|
UTSW |
1 |
59,326,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2016-08-02 |