Incidental Mutation 'IGL03238:Tmem101'
ID414183
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem101
Ensembl Gene ENSMUSG00000020921
Gene Nametransmembrane protein 101
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.236) question?
Stock #IGL03238
Quality Score
Status
Chromosome11
Chromosomal Location102152546-102156404 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 102155785 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 86 (L86Q)
Ref Sequence ENSEMBL: ENSMUSP00000021296 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021296]
Predicted Effect probably damaging
Transcript: ENSMUST00000021296
AA Change: L86Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000021296
Gene: ENSMUSG00000020921
AA Change: L86Q

DomainStartEndE-ValueType
Pfam:TMEM101 8 256 9.9e-122 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136434
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143986
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2 A C 3: 60,024,918 T285P probably benign Het
Abcf1 T C 17: 35,963,323 K186E probably damaging Het
Adam3 T C 8: 24,687,965 probably null Het
Art1 T C 7: 102,110,749 V85A possibly damaging Het
Ccdc110 A G 8: 45,941,822 H250R probably benign Het
Cyp3a13 T A 5: 137,898,889 I388F probably damaging Het
Dnah11 C T 12: 118,109,898 V1425M probably damaging Het
Donson G A 16: 91,681,246 Q22* probably null Het
Eif2b2 A G 12: 85,223,399 T238A probably benign Het
Emc2 T A 15: 43,507,853 probably null Het
Fkbp4 A T 6: 128,434,757 V123E probably damaging Het
Frem2 A T 3: 53,656,261 M275K possibly damaging Het
Gcat T A 15: 79,036,010 probably benign Het
Gemin2 G A 12: 59,016,962 probably benign Het
Ilf3 T A 9: 21,392,350 V169E probably damaging Het
Klra17 T C 6: 129,868,810 H147R probably benign Het
Lama5 A G 2: 180,188,574 I1880T probably benign Het
Lzts1 T C 8: 69,138,794 D234G probably damaging Het
Map3k4 G A 17: 12,271,158 P462L probably benign Het
March6 C A 15: 31,461,941 probably benign Het
Mcm6 A T 1: 128,355,520 F83I probably benign Het
Mtpn A G 6: 35,522,773 L32P probably damaging Het
Mybpc3 A T 2: 91,131,659 I841F probably damaging Het
Ndst2 G T 14: 20,728,504 H399N probably damaging Het
Npat G T 9: 53,570,426 V1145F probably damaging Het
Olfr65 G A 7: 103,906,510 A21T probably benign Het
P2ry1 T A 3: 61,004,495 S352T probably damaging Het
Plaa T C 4: 94,583,896 T326A probably benign Het
Ppdpf T C 2: 181,187,880 S43P probably benign Het
Prpmp5 T A 6: 132,312,345 Q172L unknown Het
Setd1a C T 7: 127,785,546 T523I possibly damaging Het
Sgcz C T 8: 37,563,140 probably null Het
Slc12a2 T C 18: 57,914,234 Y740H possibly damaging Het
Stab2 A G 10: 86,855,121 C745R probably damaging Het
Tmtc3 A C 10: 100,477,840 F57V probably damaging Het
Vps50 A G 6: 3,594,771 K778R possibly damaging Het
Washc5 G A 15: 59,346,842 T692M probably damaging Het
Zc3hav1 A T 6: 38,332,750 V379D probably damaging Het
Zfp142 G T 1: 74,576,278 R459S probably benign Het
Zfp512b A G 2: 181,589,760 V199A probably damaging Het
Other mutations in Tmem101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01085:Tmem101 APN 11 102154660 missense probably damaging 0.99
IGL01096:Tmem101 APN 11 102154552 splice site probably null
IGL01593:Tmem101 APN 11 102155878 missense probably damaging 1.00
IGL01814:Tmem101 APN 11 102153458 missense possibly damaging 0.58
IGL02451:Tmem101 APN 11 102153293 missense probably damaging 1.00
R0462:Tmem101 UTSW 11 102155867 missense probably benign 0.08
R0848:Tmem101 UTSW 11 102155866 missense possibly damaging 0.65
R1465:Tmem101 UTSW 11 102153329 missense probably damaging 0.97
R1465:Tmem101 UTSW 11 102153329 missense probably damaging 0.97
R1722:Tmem101 UTSW 11 102154693 missense probably damaging 1.00
R1928:Tmem101 UTSW 11 102153396 missense probably benign
R2082:Tmem101 UTSW 11 102153377 missense probably benign 0.17
R4577:Tmem101 UTSW 11 102155837 missense possibly damaging 0.48
R4724:Tmem101 UTSW 11 102153443 missense probably benign 0.32
R4729:Tmem101 UTSW 11 102156329 missense probably benign 0.25
R5146:Tmem101 UTSW 11 102154624 missense probably benign
R5184:Tmem101 UTSW 11 102156233 missense possibly damaging 0.78
Posted On2016-08-02