Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03115:Srpk2'

419404

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Srpk2

Ensembl Gene

ENSMUSG00000062604

Gene Name

serine/arginine-rich protein specific kinase 2

Synonyms

WBP6, mSRPK2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03115

Quality Score

Status

Chromosome

Chromosomal Location

23708262-23889615 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 23729616 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000085734 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000088392] [ENSMUST00000196388] [ENSMUST00000196929]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000088392

SMART Domains

Protein: ENSMUSP00000085734
Gene: ENSMUSG00000062604

Domain	Start	End	E-Value	Type
low complexity region	5	46	N/A	INTRINSIC
Pfam:Pkinase	79	228	1.3e-22	PFAM
Pfam:Pkinase_Tyr	79	228	1e-9	PFAM
coiled coil region	263	314	N/A	INTRINSIC
coiled coil region	339	373	N/A	INTRINSIC
low complexity region	393	406	N/A	INTRINSIC
Pfam:Pkinase	506	680	1.9e-18	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000196388

SMART Domains

Protein: ENSMUSP00000143453
Gene: ENSMUSG00000062604

Domain	Start	End	E-Value	Type
S_TKc	3	129	7.2e-6	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000196929

SMART Domains

Protein: ENSMUSP00000143216
Gene: ENSMUSG00000062604

Domain	Start	End	E-Value	Type
Pfam:Pkinase_Tyr	1	131	2.6e-8	PFAM
Pfam:Pkinase	2	130	2.3e-18	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200173

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a targeted allele exhibit normal phenotype. [provided by MGI curators]

Allele List at MGI

All alleles(39) : Targeted(3) Gene trapped(36)

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamdec1	T	A	14: 68,808,802 (GRCm39)	H302L	probably damaging	Het
Adamts12	T	A	15: 11,263,422 (GRCm39)	C595S	probably damaging	Het
Arid2	G	A	15: 96,268,154 (GRCm39)	V756I	probably damaging	Het
Asah1	A	T	8: 41,813,336 (GRCm39)	W26R	possibly damaging	Het
Brinp1	C	T	4: 68,822,973 (GRCm39)		probably null	Het
Cers2	A	G	3: 95,228,663 (GRCm39)	D162G	probably damaging	Het
Clasp1	G	T	1: 118,429,053 (GRCm39)	E106*	probably null	Het
Col12a1	T	C	9: 79,588,719 (GRCm39)	E1132G	probably damaging	Het
Dhdds	G	T	4: 133,710,182 (GRCm39)	H196N	probably benign	Het
Eps8	T	C	6: 137,504,379 (GRCm39)	D118G	probably damaging	Het
Fmo9	A	G	1: 166,505,220 (GRCm39)	S7P	probably damaging	Het
Gamt	A	G	10: 80,094,272 (GRCm39)	L197P	probably damaging	Het
Grb7	A	G	11: 98,341,945 (GRCm39)	I82V	probably damaging	Het
Hectd2	T	C	19: 36,577,121 (GRCm39)		probably null	Het
Ilk	T	C	7: 105,389,542 (GRCm39)	V83A	probably damaging	Het
Kif21a	T	A	15: 90,869,598 (GRCm39)	I418F	probably damaging	Het
Kndc1	A	G	7: 139,501,425 (GRCm39)	I905V	probably benign	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Morc3	T	C	16: 93,667,971 (GRCm39)	I710T	probably damaging	Het
Nefm	T	C	14: 68,357,728 (GRCm39)		probably benign	Het
Or10d5	T	C	9: 39,862,040 (GRCm39)	E9G	probably damaging	Het
Or2f2	A	G	6: 42,767,599 (GRCm39)	T209A	probably benign	Het
Or8g23	C	A	9: 38,971,259 (GRCm39)	R234S	probably damaging	Het
Pard6g	T	G	18: 80,123,068 (GRCm39)	L34W	probably damaging	Het
Patj	C	T	4: 98,332,040 (GRCm39)	S562L	probably damaging	Het
Pcsk4	A	G	10: 80,164,883 (GRCm39)	I61T	probably damaging	Het
Pcsk7	T	A	9: 45,825,670 (GRCm39)	H300Q	probably damaging	Het
Pip5kl1	A	G	2: 32,470,033 (GRCm39)	D288G	probably damaging	Het
Plxnb2	T	A	15: 89,046,641 (GRCm39)		probably benign	Het
Poldip2	T	C	11: 78,411,970 (GRCm39)		probably benign	Het
Ralgapa2	T	C	2: 146,266,734 (GRCm39)	Y614C	probably damaging	Het
Rarres1	C	A	3: 67,403,145 (GRCm39)		probably null	Het
Samd3	C	T	10: 26,147,606 (GRCm39)	T427M	probably damaging	Het
Skap1	A	G	11: 96,593,446 (GRCm39)	I98V	probably benign	Het
Skint11	T	C	4: 114,101,820 (GRCm39)	S87P	probably damaging	Het
Slc22a22	T	G	15: 57,126,670 (GRCm39)	E133A	probably damaging	Het
Slc23a2	T	C	2: 131,933,185 (GRCm39)	Y91C	probably damaging	Het
Slc6a20b	T	A	9: 123,426,403 (GRCm39)	E494V	possibly damaging	Het
Slco1a4	A	T	6: 141,765,329 (GRCm39)	D304E	probably benign	Het
Slco1a4	A	C	6: 141,763,585 (GRCm39)	M377R	probably damaging	Het
Supt3	T	G	17: 45,352,114 (GRCm39)	C271W	probably damaging	Het
Taar7d	C	A	10: 23,903,539 (GRCm39)	F140L	probably benign	Het
Tmbim7	T	C	5: 3,729,158 (GRCm39)	*225Q	probably null	Het
Tpst1	T	C	5: 130,130,752 (GRCm39)	I74T	probably damaging	Het
Utp3	T	C	5: 88,703,179 (GRCm39)	V236A	possibly damaging	Het
Vmn2r55	A	T	7: 12,404,558 (GRCm39)	F282I	probably damaging	Het
Vwa5b1	A	T	4: 138,327,460 (GRCm39)	I372N	possibly damaging	Het
Wtip	C	T	7: 33,824,958 (GRCm39)	A209T	probably damaging	Het
Zbbx	T	C	3: 74,985,867 (GRCm39)	D395G	probably benign	Het
Zfp273	A	T	13: 67,973,769 (GRCm39)	H299L	probably damaging	Het
Zfp459	G	A	13: 67,556,796 (GRCm39)	R96*	probably null	Het

Other mutations in Srpk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00697:Srpk2	APN	5	23,745,377 (GRCm39)	missense	probably benign	0.10
IGL02057:Srpk2	APN	5	23,723,705 (GRCm39)	missense	probably damaging	0.99
IGL02217:Srpk2	APN	5	23,750,568 (GRCm39)	missense	probably damaging	1.00
FR4737:Srpk2	UTSW	5	23,750,194 (GRCm39)	splice site	probably null
P0008:Srpk2	UTSW	5	23,718,976 (GRCm39)	missense	probably damaging	1.00
R0142:Srpk2	UTSW	5	23,732,928 (GRCm39)	missense	probably damaging	0.97
R0462:Srpk2	UTSW	5	23,723,424 (GRCm39)	missense	probably damaging	1.00
R0992:Srpk2	UTSW	5	23,750,541 (GRCm39)	missense	probably damaging	0.99
R1569:Srpk2	UTSW	5	23,719,024 (GRCm39)	missense	probably damaging	1.00
R1677:Srpk2	UTSW	5	23,730,748 (GRCm39)	splice site	probably null
R1696:Srpk2	UTSW	5	23,753,492 (GRCm39)	nonsense	probably null
R1752:Srpk2	UTSW	5	23,733,017 (GRCm39)	missense	probably damaging	1.00
R1862:Srpk2	UTSW	5	23,729,148 (GRCm39)	missense	probably benign	0.32
R1989:Srpk2	UTSW	5	23,723,421 (GRCm39)	missense	probably damaging	1.00
R2173:Srpk2	UTSW	5	23,723,613 (GRCm39)	splice site	probably null
R4096:Srpk2	UTSW	5	23,745,500 (GRCm39)	intron	probably benign
R4271:Srpk2	UTSW	5	23,753,513 (GRCm39)	missense	possibly damaging	0.95
R4894:Srpk2	UTSW	5	23,750,527 (GRCm39)	missense	probably damaging	1.00
R5043:Srpk2	UTSW	5	23,729,515 (GRCm39)	missense	probably benign
R5044:Srpk2	UTSW	5	23,729,390 (GRCm39)	missense	possibly damaging	0.91
R5309:Srpk2	UTSW	5	23,730,716 (GRCm39)	missense	probably damaging	0.97
R5478:Srpk2	UTSW	5	23,729,181 (GRCm39)	missense	possibly damaging	0.71
R5568:Srpk2	UTSW	5	23,730,697 (GRCm39)	missense	possibly damaging	0.73
R5665:Srpk2	UTSW	5	23,723,475 (GRCm39)	missense	probably damaging	0.99
R5678:Srpk2	UTSW	5	23,729,604 (GRCm39)	frame shift	probably null
R6364:Srpk2	UTSW	5	23,745,465 (GRCm39)	missense	probably damaging	1.00
R7201:Srpk2	UTSW	5	23,712,626 (GRCm39)	missense	possibly damaging	0.64
R7597:Srpk2	UTSW	5	23,753,517 (GRCm39)	missense	possibly damaging	0.96
R8251:Srpk2	UTSW	5	23,729,266 (GRCm39)	missense	probably benign
R8477:Srpk2	UTSW	5	23,718,986 (GRCm39)	missense	probably benign	0.03
R9348:Srpk2	UTSW	5	23,719,671 (GRCm39)	missense	probably damaging	0.98
R9606:Srpk2	UTSW	5	23,729,604 (GRCm39)	missense	probably benign
R9745:Srpk2	UTSW	5	23,880,874 (GRCm39)	intron	probably benign
RF035:Srpk2	UTSW	5	23,730,573 (GRCm39)	utr 3 prime	probably benign
RF042:Srpk2	UTSW	5	23,730,573 (GRCm39)	utr 3 prime	probably benign

Posted On

2016-08-02