Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03367:Sult3a1'

420121

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sult3a1

Ensembl Gene

ENSMUSG00000069668

Gene Name

sulfotransferase family 3A, member 1

Synonyms

Sultx2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.194) question?

Stock #

IGL03367

Quality Score

Status

Chromosome

Chromosomal Location

33733717-33755528 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 33753342 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 213 (V213L)

Ref Sequence

ENSEMBL: ENSMUSP00000151228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092597] [ENSMUST00000218204]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000092597
AA Change: V213L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000090259
Gene: ENSMUSG00000069668
AA Change: V213L

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	36	283	1.8e-81	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217760

Predicted Effect

probably benign
Transcript: ENSMUST00000218204
AA Change: V213L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	A	T	16: 20,211,561 (GRCm39)		probably benign	Het
Adra1a	G	A	14: 66,875,438 (GRCm39)	V138I	possibly damaging	Het
Alpk3	A	G	7: 80,744,738 (GRCm39)	I1278V	probably benign	Het
Asb6	A	T	2: 30,714,691 (GRCm39)	I185N	possibly damaging	Het
Atg9a	A	G	1: 75,164,601 (GRCm39)	V121A	probably benign	Het
Cdc42bpb	A	G	12: 111,302,593 (GRCm39)	Y155H	probably damaging	Het
Ceacam15	A	C	7: 16,409,512 (GRCm39)	S8A	possibly damaging	Het
Cep170b	T	A	12: 112,703,672 (GRCm39)	D615E	probably benign	Het
Cntn6	G	T	6: 104,781,299 (GRCm39)	G462C	probably damaging	Het
Col8a2	A	G	4: 126,205,991 (GRCm39)	D667G	probably damaging	Het
Cyp2c29	A	G	19: 39,317,659 (GRCm39)	K382E	probably damaging	Het
Dgkd	T	C	1: 87,868,030 (GRCm39)		probably null	Het
Dkk2	C	T	3: 131,883,838 (GRCm39)	T246I	probably damaging	Het
Dnah5	T	C	15: 28,234,473 (GRCm39)	L294P	possibly damaging	Het
Erbb2	G	T	11: 98,313,701 (GRCm39)		probably null	Het
Fn1	A	G	1: 71,636,712 (GRCm39)	F2147L	probably benign	Het
Gm11149	G	A	9: 49,457,646 (GRCm39)		probably benign	Het
Gnrhr	C	T	5: 86,330,190 (GRCm39)	V277I	probably benign	Het
H2-T10	T	A	17: 36,431,285 (GRCm39)	E129V	possibly damaging	Het
Hmgcr	T	C	13: 96,802,361 (GRCm39)	T108A	probably damaging	Het
Hnrnph3	A	T	10: 62,853,008 (GRCm39)	I196N	probably damaging	Het
Insyn1	A	G	9: 58,406,381 (GRCm39)	H97R	probably damaging	Het
Kcnq5	T	C	1: 21,473,289 (GRCm39)	K653E	probably damaging	Het
Lgi2	C	A	5: 52,719,502 (GRCm39)	D100Y	probably damaging	Het
Mettl15	T	A	2: 108,961,916 (GRCm39)	H231L	probably benign	Het
Mthfd1l	A	G	10: 4,056,536 (GRCm39)		probably benign	Het
Pik3cg	A	G	12: 32,242,120 (GRCm39)	S997P	probably benign	Het
Pla2g1b	T	C	5: 115,610,173 (GRCm39)	C105R	probably damaging	Het
Ppil1	A	T	17: 29,471,218 (GRCm39)		probably benign	Het
Pramel22	C	T	4: 143,382,193 (GRCm39)	V168I	possibly damaging	Het
Rbbp8	A	G	18: 11,854,776 (GRCm39)	T334A	probably benign	Het
Slc15a4	T	C	5: 127,679,005 (GRCm39)	Y445C	probably damaging	Het
Sox14	A	C	9: 99,757,715 (GRCm39)	I8S	probably damaging	Het
Spice1	A	G	16: 44,176,541 (GRCm39)	T44A	probably damaging	Het
Vkorc1l1	C	A	5: 130,011,148 (GRCm39)	Y111*	probably null	Het
Wdr47	G	T	3: 108,537,089 (GRCm39)		probably benign	Het
Wdr90	A	G	17: 26,066,765 (GRCm39)		probably benign	Het

Other mutations in Sult3a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01984:Sult3a1	APN	10	33,755,205 (GRCm39)	nonsense	probably null
IGL02269:Sult3a1	APN	10	33,755,259 (GRCm39)	missense	probably benign	0.25
IGL02302:Sult3a1	APN	10	33,742,571 (GRCm39)	missense	possibly damaging	0.81
IGL02947:Sult3a1	APN	10	33,740,046 (GRCm39)	missense	possibly damaging	0.92
IGL02966:Sult3a1	APN	10	33,753,269 (GRCm39)	splice site	probably benign
IGL03271:Sult3a1	APN	10	33,739,997 (GRCm39)	missense	probably benign
R0539:Sult3a1	UTSW	10	33,742,519 (GRCm39)	missense	probably damaging	1.00
R0627:Sult3a1	UTSW	10	33,740,010 (GRCm39)	missense	probably benign	0.00
R0838:Sult3a1	UTSW	10	33,755,284 (GRCm39)	missense	probably damaging	0.99
R1538:Sult3a1	UTSW	10	33,746,166 (GRCm39)	missense	probably benign	0.29
R1604:Sult3a1	UTSW	10	33,742,616 (GRCm39)	missense	probably damaging	1.00
R1622:Sult3a1	UTSW	10	33,746,246 (GRCm39)	missense	probably benign	0.39
R3031:Sult3a1	UTSW	10	33,753,345 (GRCm39)	missense	possibly damaging	0.70
R4933:Sult3a1	UTSW	10	33,742,550 (GRCm39)	missense	probably damaging	1.00
R5943:Sult3a1	UTSW	10	33,742,637 (GRCm39)	missense	probably damaging	0.99
R6440:Sult3a1	UTSW	10	33,746,198 (GRCm39)	missense	possibly damaging	0.46
R7140:Sult3a1	UTSW	10	33,753,283 (GRCm39)	missense	probably damaging	1.00
R7356:Sult3a1	UTSW	10	33,742,579 (GRCm39)	missense	probably benign	0.25
R8342:Sult3a1	UTSW	10	33,742,517 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02