Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02269:Sult3a1'

287059

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sult3a1

Ensembl Gene

ENSMUSG00000069668

Gene Name

sulfotransferase family 3A, member 1

Synonyms

Sultx2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.194) question?

Stock #

IGL02269

Quality Score

Status

Chromosome

Chromosomal Location

33733717-33755528 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 33755259 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 275 (F275L)

Ref Sequence

ENSEMBL: ENSMUSP00000151228 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092597] [ENSMUST00000218204]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000092597
AA Change: F275L

PolyPhen 2 Score 0.248 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000090259
Gene: ENSMUSG00000069668
AA Change: F275L

Domain	Start	End	E-Value	Type
Pfam:Sulfotransfer_1	36	283	1.8e-81	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000218204
AA Change: F275L

PolyPhen 2 Score 0.248 (Sensitivity: 0.91; Specificity: 0.88)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933414I15Rik	A	G	11: 50,833,425 (GRCm39)	V59A	unknown	Het
A2ml1	C	A	6: 128,530,301 (GRCm39)		probably benign	Het
Akap13	G	A	7: 75,252,659 (GRCm39)	R263H	probably benign	Het
B3galt5	A	G	16: 96,116,730 (GRCm39)	D121G	possibly damaging	Het
Becn1	A	G	11: 101,182,361 (GRCm39)		probably benign	Het
Carmil1	A	T	13: 24,339,393 (GRCm39)	L150*	probably null	Het
Cep170	A	T	1: 176,596,932 (GRCm39)	M475K	probably benign	Het
Cyp24a1	C	T	2: 170,338,492 (GRCm39)	G68D	probably damaging	Het
Cyp3a44	A	T	5: 145,742,547 (GRCm39)	I18N	probably benign	Het
Dmrt2	T	C	19: 25,655,823 (GRCm39)	V474A	probably benign	Het
Dtnb	A	G	12: 3,646,691 (GRCm39)	D64G	probably damaging	Het
Epb41l3	T	C	17: 69,554,568 (GRCm39)	S223P	probably damaging	Het
Ephb2	A	G	4: 136,498,360 (GRCm39)	Y240H	possibly damaging	Het
Extl3	T	C	14: 65,315,032 (GRCm39)	Y50C	probably damaging	Het
Fat3	A	C	9: 15,826,873 (GRCm39)	S4360A	possibly damaging	Het
Fbxo9	A	T	9: 77,994,835 (GRCm39)	V230E	probably damaging	Het
Frmd4a	T	C	2: 4,609,045 (GRCm39)	M971T	probably benign	Het
Gm7275	A	G	16: 47,894,185 (GRCm39)		noncoding transcript	Het
Hyal6	C	T	6: 24,740,858 (GRCm39)	T337I	probably damaging	Het
Obsl1	C	T	1: 75,464,357 (GRCm39)	V1650M	probably damaging	Het
Or1j13	A	T	2: 36,369,579 (GRCm39)	S188T	possibly damaging	Het
Or52z14	T	A	7: 103,253,089 (GRCm39)	I76N	probably damaging	Het
Or7e169	A	T	9: 19,757,024 (GRCm39)	I297N	possibly damaging	Het
Or8c8	A	T	9: 38,165,232 (GRCm39)	D173V	possibly damaging	Het
Pcdh7	A	C	5: 58,070,664 (GRCm39)	E1114A	probably damaging	Het
Pde8a	C	T	7: 80,958,550 (GRCm39)		probably benign	Het
Pdzrn4	A	T	15: 92,667,731 (GRCm39)	S628C	probably damaging	Het
Pear1	C	T	3: 87,663,571 (GRCm39)	G376S	probably damaging	Het
Plekha6	C	T	1: 133,215,587 (GRCm39)	T644M	possibly damaging	Het
Plpp1	T	A	13: 112,993,526 (GRCm39)	C153S	probably damaging	Het
Ptpn3	G	A	4: 57,197,510 (GRCm39)	T793M	possibly damaging	Het
Rdh13	A	T	7: 4,448,497 (GRCm39)	L5Q	possibly damaging	Het
Rimbp2	G	T	5: 128,851,359 (GRCm39)	D862E	probably damaging	Het
Rita1	C	T	5: 120,747,858 (GRCm39)	A147T	probably damaging	Het
Scamp1	C	T	13: 94,368,694 (GRCm39)		probably benign	Het
Scamp3	A	G	3: 89,088,041 (GRCm39)	T178A	probably benign	Het
Sh3tc1	A	G	5: 35,863,628 (GRCm39)	V853A	probably benign	Het
Snrnp200	C	T	2: 127,071,911 (GRCm39)	T1197M	possibly damaging	Het
Tenm4	A	T	7: 96,473,029 (GRCm39)	I905F	probably damaging	Het
Tgm3	T	A	2: 129,866,438 (GRCm39)	S119T	probably benign	Het
Tmem131l	A	T	3: 83,845,357 (GRCm39)	D424E	possibly damaging	Het
Tmem45b	G	T	9: 31,339,279 (GRCm39)	C145*	probably null	Het
Unc5c	G	A	3: 141,494,743 (GRCm39)	R352H	probably damaging	Het
Vmn2r12	A	G	5: 109,234,343 (GRCm39)	L623P	probably damaging	Het
Vmn2r68	T	C	7: 84,870,947 (GRCm39)	M779V	possibly damaging	Het
Zfhx2	T	C	14: 55,309,393 (GRCm39)	N902S	probably benign	Het

Other mutations in Sult3a1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01984:Sult3a1	APN	10	33,755,205 (GRCm39)	nonsense	probably null
IGL02302:Sult3a1	APN	10	33,742,571 (GRCm39)	missense	possibly damaging	0.81
IGL02947:Sult3a1	APN	10	33,740,046 (GRCm39)	missense	possibly damaging	0.92
IGL02966:Sult3a1	APN	10	33,753,269 (GRCm39)	splice site	probably benign
IGL03271:Sult3a1	APN	10	33,739,997 (GRCm39)	missense	probably benign
IGL03367:Sult3a1	APN	10	33,753,342 (GRCm39)	missense	probably benign	0.01
R0539:Sult3a1	UTSW	10	33,742,519 (GRCm39)	missense	probably damaging	1.00
R0627:Sult3a1	UTSW	10	33,740,010 (GRCm39)	missense	probably benign	0.00
R0838:Sult3a1	UTSW	10	33,755,284 (GRCm39)	missense	probably damaging	0.99
R1538:Sult3a1	UTSW	10	33,746,166 (GRCm39)	missense	probably benign	0.29
R1604:Sult3a1	UTSW	10	33,742,616 (GRCm39)	missense	probably damaging	1.00
R1622:Sult3a1	UTSW	10	33,746,246 (GRCm39)	missense	probably benign	0.39
R3031:Sult3a1	UTSW	10	33,753,345 (GRCm39)	missense	possibly damaging	0.70
R4933:Sult3a1	UTSW	10	33,742,550 (GRCm39)	missense	probably damaging	1.00
R5943:Sult3a1	UTSW	10	33,742,637 (GRCm39)	missense	probably damaging	0.99
R6440:Sult3a1	UTSW	10	33,746,198 (GRCm39)	missense	possibly damaging	0.46
R7140:Sult3a1	UTSW	10	33,753,283 (GRCm39)	missense	probably damaging	1.00
R7356:Sult3a1	UTSW	10	33,742,579 (GRCm39)	missense	probably benign	0.25
R8342:Sult3a1	UTSW	10	33,742,517 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16