Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03383:Vmn2r13'

420757

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r13

Ensembl Gene

ENSMUSG00000091635

Gene Name

vomeronasal 2, receptor 13

Synonyms

Gm4867

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL03383

Quality Score

Status

Chromosome

Chromosomal Location

109303889-109339973 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 109304398 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 678 (T678A)

Ref Sequence

ENSEMBL: ENSMUSP00000052977 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053253]

AlphaFold

L7N1X2

Predicted Effect

probably damaging
Transcript: ENSMUST00000053253
AA Change: T678A

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000052977
Gene: ENSMUSG00000091635
AA Change: T678A

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	76	463	2.8e-29	PFAM
Pfam:NCD3G	506	560	1.3e-18	PFAM
Pfam:7tm_3	593	828	1.8e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agbl4	C	T	4: 111,514,620 (GRCm39)		probably benign	Het
Cit	T	C	5: 116,011,904 (GRCm39)		probably benign	Het
Clmp	A	G	9: 40,685,737 (GRCm39)	N211S	probably damaging	Het
Cnot2	A	G	10: 116,330,722 (GRCm39)		probably benign	Het
Cntn6	A	G	6: 104,753,418 (GRCm39)		probably benign	Het
Dnajb9	C	T	12: 44,255,096 (GRCm39)		probably benign	Het
Ece2	T	A	16: 20,451,847 (GRCm39)	N411K	possibly damaging	Het
Fshr	A	G	17: 89,354,127 (GRCm39)	I77T	possibly damaging	Het
Fshr	A	G	17: 89,293,121 (GRCm39)	M519T	probably damaging	Het
Gm10654	G	A	8: 71,384,775 (GRCm39)		noncoding transcript	Het
Gm5093	A	G	17: 46,750,517 (GRCm39)	I170T	probably benign	Het
Meis3	A	G	7: 15,917,744 (GRCm39)	K299R	probably damaging	Het
Nxf1	T	C	19: 8,741,061 (GRCm39)	F15L	probably damaging	Het
Nxpe3	T	C	16: 55,670,076 (GRCm39)	D343G	probably benign	Het
Or4a73	A	T	2: 89,420,656 (GRCm39)	Y268N	probably benign	Het
Polr3k	A	G	2: 181,507,820 (GRCm39)	T65A	probably damaging	Het
Preb	A	T	5: 31,115,665 (GRCm39)	W222R	probably damaging	Het
Psmd11	T	C	11: 80,360,671 (GRCm39)	I56T	probably damaging	Het
Rtkn2	A	G	10: 67,853,667 (GRCm39)	T232A	probably damaging	Het
Scaf11	T	C	15: 96,318,064 (GRCm39)		probably null	Het
Slc4a10	A	T	2: 62,097,780 (GRCm39)	K493M	probably damaging	Het
Stard10	A	G	7: 100,991,777 (GRCm39)	K112E	probably damaging	Het
Sugp1	A	T	8: 70,522,217 (GRCm39)		probably benign	Het
Tasor	A	G	14: 27,163,918 (GRCm39)	I235V	possibly damaging	Het
Tmem156	T	C	5: 65,233,040 (GRCm39)	E139G	probably damaging	Het
Tubd1	C	T	11: 86,439,834 (GRCm39)		probably benign	Het
Uap1	G	A	1: 169,986,460 (GRCm39)	T174M	probably damaging	Het
Vmn2r84	A	T	10: 130,222,556 (GRCm39)	C555S	probably damaging	Het
Vps13d	T	C	4: 144,894,889 (GRCm39)		probably null	Het
Vps8	T	C	16: 21,254,573 (GRCm39)		probably null	Het
Wee1	A	G	7: 109,738,899 (GRCm39)	N590S	probably damaging	Het
Zfp112	C	A	7: 23,825,103 (GRCm39)	S357Y	probably damaging	Het
Zfp423	T	A	8: 88,586,080 (GRCm39)	K48*	probably null	Het
Zscan4d	A	G	7: 10,896,692 (GRCm39)	V226A	probably benign	Het

Other mutations in Vmn2r13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00965:Vmn2r13	APN	5	109,303,964 (GRCm39)	missense	probably damaging	1.00
IGL01373:Vmn2r13	APN	5	109,304,568 (GRCm39)	missense	probably damaging	1.00
IGL01946:Vmn2r13	APN	5	109,322,085 (GRCm39)	missense	probably benign	0.01
IGL01971:Vmn2r13	APN	5	109,321,981 (GRCm39)	missense	probably benign	0.01
IGL02636:Vmn2r13	APN	5	109,339,883 (GRCm39)	missense	probably damaging	0.98
IGL03062:Vmn2r13	APN	5	109,304,148 (GRCm39)	missense	probably damaging	1.00
IGL03173:Vmn2r13	APN	5	109,319,645 (GRCm39)	missense	possibly damaging	0.95
IGL03301:Vmn2r13	APN	5	109,305,955 (GRCm39)	missense	probably damaging	0.99
IGL03048:Vmn2r13	UTSW	5	109,304,151 (GRCm39)	missense	probably damaging	1.00
R0123:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0134:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0220:Vmn2r13	UTSW	5	109,304,332 (GRCm39)	missense	probably damaging	1.00
R0225:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0393:Vmn2r13	UTSW	5	109,304,395 (GRCm39)	missense	probably benign	0.01
R0410:Vmn2r13	UTSW	5	109,321,679 (GRCm39)	missense	probably benign	0.35
R0787:Vmn2r13	UTSW	5	109,304,713 (GRCm39)	missense	probably damaging	0.99
R1200:Vmn2r13	UTSW	5	109,322,068 (GRCm39)	missense	probably damaging	1.00
R1448:Vmn2r13	UTSW	5	109,322,001 (GRCm39)	missense	probably damaging	1.00
R1782:Vmn2r13	UTSW	5	109,306,040 (GRCm39)	missense	probably benign	0.08
R1939:Vmn2r13	UTSW	5	109,339,852 (GRCm39)	missense	possibly damaging	0.88
R2029:Vmn2r13	UTSW	5	109,339,943 (GRCm39)	missense	probably benign	0.13
R2125:Vmn2r13	UTSW	5	109,306,058 (GRCm39)	missense	probably benign	0.00
R2126:Vmn2r13	UTSW	5	109,306,058 (GRCm39)	missense	probably benign	0.00
R2379:Vmn2r13	UTSW	5	109,319,644 (GRCm39)	missense	probably benign	0.05
R2680:Vmn2r13	UTSW	5	109,322,178 (GRCm39)	missense	possibly damaging	0.66
R2888:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R2889:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R2890:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R3014:Vmn2r13	UTSW	5	109,319,627 (GRCm39)	missense	possibly damaging	0.81
R3683:Vmn2r13	UTSW	5	109,304,721 (GRCm39)	missense	probably damaging	1.00
R4074:Vmn2r13	UTSW	5	109,304,566 (GRCm39)	missense	probably damaging	1.00
R4599:Vmn2r13	UTSW	5	109,304,322 (GRCm39)	missense	probably damaging	1.00
R4614:Vmn2r13	UTSW	5	109,323,065 (GRCm39)	missense	probably benign	0.01
R4805:Vmn2r13	UTSW	5	109,304,331 (GRCm39)	missense	probably damaging	1.00
R4822:Vmn2r13	UTSW	5	109,321,938 (GRCm39)	missense	probably damaging	0.99
R4943:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R5263:Vmn2r13	UTSW	5	109,321,841 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r13	UTSW	5	109,339,805 (GRCm39)	missense	probably benign	0.00
R5502:Vmn2r13	UTSW	5	109,321,580 (GRCm39)	missense	probably damaging	1.00
R5554:Vmn2r13	UTSW	5	109,339,860 (GRCm39)	missense	possibly damaging	0.49
R5563:Vmn2r13	UTSW	5	109,321,846 (GRCm39)	missense	probably benign	0.00
R5819:Vmn2r13	UTSW	5	109,321,966 (GRCm39)	missense	possibly damaging	0.79
R6074:Vmn2r13	UTSW	5	109,322,167 (GRCm39)	missense	probably benign	0.04
R6416:Vmn2r13	UTSW	5	109,321,982 (GRCm39)	missense	probably damaging	0.99
R6419:Vmn2r13	UTSW	5	109,323,085 (GRCm39)	missense	possibly damaging	0.87
R6484:Vmn2r13	UTSW	5	109,304,540 (GRCm39)	nonsense	probably null
R6486:Vmn2r13	UTSW	5	109,304,425 (GRCm39)	missense	probably benign	0.05
R6545:Vmn2r13	UTSW	5	109,304,806 (GRCm39)	splice site	probably null
R6700:Vmn2r13	UTSW	5	109,322,938 (GRCm39)	missense	probably benign	0.00
R6897:Vmn2r13	UTSW	5	109,306,015 (GRCm39)	missense	possibly damaging	0.90
R6957:Vmn2r13	UTSW	5	109,304,753 (GRCm39)	nonsense	probably null
R7276:Vmn2r13	UTSW	5	109,321,645 (GRCm39)	missense	probably damaging	1.00
R7363:Vmn2r13	UTSW	5	109,339,909 (GRCm39)	missense	probably benign	0.03
R7443:Vmn2r13	UTSW	5	109,339,909 (GRCm39)	missense	probably benign	0.03
R7555:Vmn2r13	UTSW	5	109,319,557 (GRCm39)	splice site	probably null
R7607:Vmn2r13	UTSW	5	109,321,506 (GRCm39)	missense	probably damaging	0.98
R7719:Vmn2r13	UTSW	5	109,319,618 (GRCm39)	missense	probably benign	0.00
R8116:Vmn2r13	UTSW	5	109,322,926 (GRCm39)	missense	probably benign	0.12
R8242:Vmn2r13	UTSW	5	109,322,872 (GRCm39)	missense	possibly damaging	0.65
R8294:Vmn2r13	UTSW	5	109,322,978 (GRCm39)	missense	probably benign	0.02
R8340:Vmn2r13	UTSW	5	109,322,006 (GRCm39)	missense	probably benign	0.00
R8692:Vmn2r13	UTSW	5	109,319,514 (GRCm39)	missense	probably benign	0.03
R8742:Vmn2r13	UTSW	5	109,304,263 (GRCm39)	missense	probably benign	0.02
R9022:Vmn2r13	UTSW	5	109,304,242 (GRCm39)	missense	possibly damaging	0.94
R9281:Vmn2r13	UTSW	5	109,303,953 (GRCm39)	missense	probably damaging	1.00
R9529:Vmn2r13	UTSW	5	109,304,064 (GRCm39)	missense	probably damaging	1.00
R9708:Vmn2r13	UTSW	5	109,322,007 (GRCm39)	missense	probably benign	0.00
R9746:Vmn2r13	UTSW	5	109,339,773 (GRCm39)	critical splice donor site	probably null
X0066:Vmn2r13	UTSW	5	109,304,085 (GRCm39)	missense	probably benign	0.44

Posted On

2016-08-02