Incidental Mutation 'IGL03408:Zfp945'
| ID |
421653 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp945
|
| Ensembl Gene |
ENSMUSG00000059142 |
| Gene Name |
zinc finger protein 945 |
| Synonyms |
C730040L01Rik, A630033E08Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
IGL03408
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
23065671-23086108 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 23071511 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 150
(Y150*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124123
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088696]
[ENSMUST00000150092]
[ENSMUST00000160457]
|
| AlphaFold |
F6WAU7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000088696
AA Change: Y129*
|
| SMART Domains |
Protein: ENSMUSP00000086074
Gene: ENSMUSG00000059142
AA Change: Y129*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
13 |
68 |
9.12e-18 |
SMART |
|
ZnF_C2H2
|
210 |
232 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
238 |
260 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
266 |
288 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
322 |
344 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
350 |
372 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
378 |
400 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
406 |
428 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
434 |
456 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
462 |
484 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
490 |
512 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
518 |
540 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
546 |
568 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
574 |
596 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
602 |
624 |
9.31e1 |
SMART |
|
ZnF_C2H2
|
630 |
652 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
658 |
680 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
686 |
708 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
714 |
736 |
2.95e-3 |
SMART |
|
ZnF_C2H2
|
742 |
764 |
1.98e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000095615
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000150092
AA Change: Y150*
|
| SMART Domains |
Protein: ENSMUSP00000117978
Gene: ENSMUSG00000059142
AA Change: Y150*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
34 |
89 |
9.12e-18 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000160457
AA Change: Y150*
|
| SMART Domains |
Protein: ENSMUSP00000124123
Gene: ENSMUSG00000059142
AA Change: Y150*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
34 |
89 |
9.12e-18 |
SMART |
|
ZnF_C2H2
|
231 |
253 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
259 |
281 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
1.13e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
9.31e1 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
3.69e-4 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
735 |
757 |
2.95e-3 |
SMART |
|
ZnF_C2H2
|
763 |
785 |
1.98e-4 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca12 |
A |
T |
1: 71,303,954 (GRCm39) |
F2108I |
probably damaging |
Het |
| Aco2 |
T |
C |
15: 81,783,424 (GRCm39) |
|
probably null |
Het |
| Ccdc186 |
T |
C |
19: 56,787,163 (GRCm39) |
K602E |
probably benign |
Het |
| Ccdc85a |
T |
A |
11: 28,526,528 (GRCm39) |
H360L |
probably damaging |
Het |
| Cited2 |
A |
G |
10: 17,600,148 (GRCm39) |
H152R |
possibly damaging |
Het |
| Cluh |
C |
A |
11: 74,556,779 (GRCm39) |
R940S |
probably benign |
Het |
| Corin |
T |
A |
5: 72,500,304 (GRCm39) |
Y432F |
probably benign |
Het |
| Creb1 |
A |
G |
1: 64,615,491 (GRCm39) |
|
probably null |
Het |
| Dhx15 |
A |
T |
5: 52,317,654 (GRCm39) |
D568E |
probably damaging |
Het |
| Efcab3 |
T |
A |
11: 104,601,447 (GRCm39) |
S253R |
probably benign |
Het |
| Esam |
G |
T |
9: 37,445,949 (GRCm39) |
R162S |
possibly damaging |
Het |
| Fat3 |
T |
A |
9: 15,909,253 (GRCm39) |
K2250* |
probably null |
Het |
| Fbxl17 |
G |
A |
17: 63,387,541 (GRCm39) |
R133* |
probably null |
Het |
| Gzmc |
C |
T |
14: 56,471,473 (GRCm39) |
G23R |
probably damaging |
Het |
| Idh3a |
A |
G |
9: 54,504,206 (GRCm39) |
N189D |
probably benign |
Het |
| Il31ra |
A |
T |
13: 112,662,422 (GRCm39) |
D462E |
probably benign |
Het |
| Inava |
T |
C |
1: 136,142,143 (GRCm39) |
Y652C |
probably benign |
Het |
| Inpp5j |
G |
A |
11: 3,452,809 (GRCm39) |
A147V |
possibly damaging |
Het |
| Kalrn |
G |
A |
16: 34,134,546 (GRCm39) |
A412V |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 40,748,594 (GRCm39) |
V2968A |
probably damaging |
Het |
| Morc1 |
G |
A |
16: 48,262,775 (GRCm39) |
G42R |
probably damaging |
Het |
| Notch4 |
T |
C |
17: 34,784,542 (GRCm39) |
L85P |
probably benign |
Het |
| Or4c52 |
G |
A |
2: 89,845,915 (GRCm39) |
V214M |
probably benign |
Het |
| Or5p73 |
A |
T |
7: 108,064,554 (GRCm39) |
N8Y |
probably damaging |
Het |
| Parp4 |
T |
A |
14: 56,839,865 (GRCm39) |
H524Q |
probably damaging |
Het |
| Pole |
T |
C |
5: 110,442,426 (GRCm39) |
F285L |
probably damaging |
Het |
| Scn9a |
A |
G |
2: 66,357,091 (GRCm39) |
M1070T |
probably benign |
Het |
| Slc25a32 |
G |
A |
15: 38,963,425 (GRCm39) |
A132V |
probably benign |
Het |
| Sult2a2 |
T |
G |
7: 13,472,154 (GRCm39) |
I117S |
probably damaging |
Het |
| Suv39h2 |
T |
C |
2: 3,460,913 (GRCm39) |
N183S |
probably damaging |
Het |
| Trhr2 |
G |
A |
8: 123,085,534 (GRCm39) |
T150M |
probably damaging |
Het |
| Usp34 |
T |
A |
11: 23,396,957 (GRCm39) |
F614I |
possibly damaging |
Het |
| Vmn2r17 |
A |
G |
5: 109,577,238 (GRCm39) |
|
probably benign |
Het |
| Wfdc2 |
T |
A |
2: 164,405,283 (GRCm39) |
C61* |
probably null |
Het |
| Zfp384 |
T |
C |
6: 125,012,676 (GRCm39) |
S377P |
probably damaging |
Het |
|
| Other mutations in Zfp945 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00754:Zfp945
|
APN |
17 |
23,070,931 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01077:Zfp945
|
APN |
17 |
23,071,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02706:Zfp945
|
APN |
17 |
23,076,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Small-scale
|
UTSW |
17 |
23,069,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Zfp945
|
UTSW |
17 |
23,084,226 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0718:Zfp945
|
UTSW |
17 |
23,070,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1305:Zfp945
|
UTSW |
17 |
23,071,360 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1801:Zfp945
|
UTSW |
17 |
23,070,736 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1837:Zfp945
|
UTSW |
17 |
23,070,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2001:Zfp945
|
UTSW |
17 |
23,076,223 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4193:Zfp945
|
UTSW |
17 |
23,070,144 (GRCm39) |
unclassified |
probably benign |
|
|
R4247:Zfp945
|
UTSW |
17 |
23,069,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5026:Zfp945
|
UTSW |
17 |
23,069,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5918:Zfp945
|
UTSW |
17 |
23,069,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6076:Zfp945
|
UTSW |
17 |
23,070,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6664:Zfp945
|
UTSW |
17 |
23,071,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6997:Zfp945
|
UTSW |
17 |
23,071,543 (GRCm39) |
nonsense |
probably null |
|
|
R7040:Zfp945
|
UTSW |
17 |
23,071,264 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7479:Zfp945
|
UTSW |
17 |
23,070,340 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7566:Zfp945
|
UTSW |
17 |
23,070,727 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7948:Zfp945
|
UTSW |
17 |
23,071,096 (GRCm39) |
missense |
unknown |
|
|
R8383:Zfp945
|
UTSW |
17 |
23,070,798 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9776:Zfp945
|
UTSW |
17 |
23,070,582 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9790:Zfp945
|
UTSW |
17 |
23,071,228 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9791:Zfp945
|
UTSW |
17 |
23,071,228 (GRCm39) |
missense |
probably benign |
0.33 |
|
X0063:Zfp945
|
UTSW |
17 |
23,071,202 (GRCm39) |
unclassified |
probably benign |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation