Incidental Mutation 'R5656:Or1e1f'
ID 442344
Institutional Source Beutler Lab
Gene Symbol Or1e1f
Ensembl Gene ENSMUSG00000057050
Gene Name olfactory receptor family 1 subfamily E member 1F
Synonyms Olfr397, GA_x6K02T2P1NL-4121434-4122381, MOR135-28
MMRRC Submission 043302-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R5656 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73855436-73856383 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 73855536 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 34 (M34K)
Ref Sequence ENSEMBL: ENSMUSP00000150172 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108465] [ENSMUST00000121280] [ENSMUST00000213134] [ENSMUST00000216291]
AlphaFold Q8VEZ6
Predicted Effect probably damaging
Transcript: ENSMUST00000108465
AA Change: M34K

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000104105
Gene: ENSMUSG00000062128
AA Change: M34K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.9e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7.8e-8 PFAM
Pfam:7tm_1 41 290 1e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000121280
AA Change: M34K

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113870
Gene: ENSMUSG00000057050
AA Change: M34K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 305 1.3e-6 PFAM
Pfam:7tm_1 41 290 4.3e-35 PFAM
Pfam:7tm_4 139 283 1.2e-44 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213134
AA Change: M34K

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215020
Predicted Effect probably damaging
Transcript: ENSMUST00000216291
AA Change: M34K

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik A G 8: 106,436,144 (GRCm39) S139G probably benign Het
Adrb3 T C 8: 27,717,405 (GRCm39) D348G probably damaging Het
Atg2b A G 12: 105,587,587 (GRCm39) V1959A probably benign Het
Bicral G A 17: 47,119,295 (GRCm39) T742M probably damaging Het
Bub1b T A 2: 118,435,912 (GRCm39) I60N probably damaging Het
Ccdc162 A G 10: 41,445,930 (GRCm39) V414A probably benign Het
Cd22 T G 7: 30,569,198 (GRCm39) Y612S probably damaging Het
Cd68 T A 11: 69,555,247 (GRCm39) I320F probably damaging Het
Clca3a2 A T 3: 144,503,393 (GRCm39) N852K probably benign Het
Cpa6 T A 1: 10,399,739 (GRCm39) H363L probably benign Het
Ddx18 A T 1: 121,489,087 (GRCm39) L320Q probably damaging Het
Dnah5 A G 15: 28,421,210 (GRCm39) D3849G probably benign Het
Eci1 T A 17: 24,656,283 (GRCm39) N164K probably damaging Het
Efs T C 14: 55,154,584 (GRCm39) T552A probably damaging Het
Fbp1 C A 13: 63,023,010 (GRCm39) V96L probably damaging Het
Gtf3c1 T A 7: 125,261,826 (GRCm39) N1139I probably benign Het
Gucy1b2 T C 14: 62,660,430 (GRCm39) Y152C probably damaging Het
Gxylt1 A T 15: 93,143,542 (GRCm39) L362Q probably damaging Het
Iqcd A G 5: 120,743,191 (GRCm39) probably null Het
Klhl41 T A 2: 69,513,876 (GRCm39) I585N possibly damaging Het
Map6 A G 7: 98,985,505 (GRCm39) K470E probably damaging Het
Mast3 T C 8: 71,238,865 (GRCm39) T496A probably damaging Het
Mbd6 A T 10: 127,121,155 (GRCm39) probably benign Het
Melk A G 4: 44,312,237 (GRCm39) K183R possibly damaging Het
Mta1 T C 12: 113,086,759 (GRCm39) V152A probably damaging Het
Naa35 G A 13: 59,770,680 (GRCm39) probably benign Het
Nav3 A C 10: 109,600,494 (GRCm39) S1378A probably damaging Het
Ncapd3 T A 9: 26,962,941 (GRCm39) D415E possibly damaging Het
Nlrp4f G A 13: 65,338,685 (GRCm39) R651* probably null Het
Or5b121 A G 19: 13,507,744 (GRCm39) T280A probably benign Het
Or5p72 A G 7: 108,021,825 (GRCm39) I16V probably benign Het
P2rx7 A T 5: 122,811,780 (GRCm39) R364W probably damaging Het
Phactr2 T C 10: 13,264,447 (GRCm39) D2G probably benign Het
Phc3 G T 3: 31,020,015 (GRCm39) S28R probably damaging Het
Ppfia1 A T 7: 144,073,711 (GRCm39) probably null Het
Prdm10 C T 9: 31,264,713 (GRCm39) T667M probably benign Het
Pwwp2b T A 7: 138,835,887 (GRCm39) S443T possibly damaging Het
Pzp T C 6: 128,467,035 (GRCm39) T1113A probably damaging Het
Rapgef6 A G 11: 54,526,962 (GRCm39) E551G possibly damaging Het
Sec23ip A G 7: 128,378,508 (GRCm39) Y774C probably damaging Het
Setdb2 T C 14: 59,656,567 (GRCm39) D266G probably damaging Het
Shank1 T C 7: 44,002,310 (GRCm39) V1343A probably benign Het
Slf2 T A 19: 44,961,674 (GRCm39) D1064E probably benign Het
Slu7 A G 11: 43,334,245 (GRCm39) K424E probably benign Het
Smg1 A T 7: 117,753,887 (GRCm39) probably benign Het
Sptlc2 A T 12: 87,393,535 (GRCm39) L264Q probably damaging Het
Sra1 A G 18: 36,811,460 (GRCm39) S93P probably damaging Het
Sult1c2 T C 17: 54,271,680 (GRCm39) E169G probably benign Het
Sv2a A G 3: 96,092,888 (GRCm39) D196G probably damaging Het
Tbc1d22b A G 17: 29,813,754 (GRCm39) I362M probably damaging Het
Tenm3 T C 8: 48,681,797 (GRCm39) D2611G probably damaging Het
Tmem43 T C 6: 91,457,690 (GRCm39) F191L probably benign Het
Trbv13-2 T A 6: 41,098,628 (GRCm39) Y68N probably benign Het
Ttn T G 2: 76,604,998 (GRCm39) D18312A possibly damaging Het
Ublcp1 A G 11: 44,356,433 (GRCm39) V95A probably damaging Het
Usp17ld A G 7: 102,900,047 (GRCm39) V295A probably damaging Het
Vmn1r29 T A 6: 58,285,152 (GRCm39) L291M possibly damaging Het
Vsig10l C T 7: 43,113,575 (GRCm39) R176* probably null Het
Zbtb46 A G 2: 181,065,210 (GRCm39) probably null Het
Zfp644 A G 5: 106,785,848 (GRCm39) V233A probably benign Het
Other mutations in Or1e1f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01797:Or1e1f APN 11 73,855,644 (GRCm39) missense probably damaging 1.00
IGL01839:Or1e1f APN 11 73,855,437 (GRCm39) start codon destroyed probably null 1.00
IGL02247:Or1e1f APN 11 73,855,688 (GRCm39) missense probably benign 0.05
IGL02876:Or1e1f APN 11 73,855,539 (GRCm39) missense possibly damaging 0.95
IGL03051:Or1e1f APN 11 73,855,860 (GRCm39) missense probably benign 0.04
IGL03123:Or1e1f APN 11 73,855,812 (GRCm39) missense probably damaging 1.00
IGL03401:Or1e1f APN 11 73,856,388 (GRCm39) utr 3 prime probably benign
3-1:Or1e1f UTSW 11 73,855,803 (GRCm39) missense possibly damaging 0.84
R0496:Or1e1f UTSW 11 73,855,706 (GRCm39) missense probably benign 0.42
R0811:Or1e1f UTSW 11 73,856,246 (GRCm39) missense probably benign 0.02
R0812:Or1e1f UTSW 11 73,856,246 (GRCm39) missense probably benign 0.02
R1503:Or1e1f UTSW 11 73,855,394 (GRCm39) utr 5 prime probably null
R2067:Or1e1f UTSW 11 73,855,740 (GRCm39) missense probably damaging 1.00
R2111:Or1e1f UTSW 11 73,855,740 (GRCm39) missense probably damaging 1.00
R4912:Or1e1f UTSW 11 73,856,166 (GRCm39) missense probably damaging 1.00
R5240:Or1e1f UTSW 11 73,855,632 (GRCm39) missense probably damaging 1.00
R5801:Or1e1f UTSW 11 73,855,772 (GRCm39) missense probably benign 0.39
R6329:Or1e1f UTSW 11 73,855,568 (GRCm39) missense possibly damaging 0.73
R6720:Or1e1f UTSW 11 73,856,291 (GRCm39) missense probably damaging 1.00
R7149:Or1e1f UTSW 11 73,856,257 (GRCm39) missense probably benign 0.01
R7283:Or1e1f UTSW 11 73,855,634 (GRCm39) missense probably damaging 1.00
R8194:Or1e1f UTSW 11 73,856,240 (GRCm39) missense probably benign 0.00
R8466:Or1e1f UTSW 11 73,855,913 (GRCm39) missense probably damaging 1.00
R8472:Or1e1f UTSW 11 73,856,223 (GRCm39) missense possibly damaging 0.78
R8882:Or1e1f UTSW 11 73,855,940 (GRCm39) missense probably damaging 0.97
R9256:Or1e1f UTSW 11 73,856,135 (GRCm39) missense probably benign 0.18
Z1176:Or1e1f UTSW 11 73,856,123 (GRCm39) frame shift probably null
Z1177:Or1e1f UTSW 11 73,855,586 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AATGTCTTCCTAAAGCATTGGC -3'
(R):5'- ACATAGCGATCATAGGCCATGG -3'

Sequencing Primer
(F):5'- GCATTGGCTTTGTGTATGTTTATAC -3'
(R):5'- GTACATTTGTGCCAGGCAAC -3'
Posted On 2016-11-09