Incidental Mutation 'IGL00494:Taar7e'
| ID |
4755 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Taar7e
|
| Ensembl Gene |
ENSMUSG00000100689 |
| Gene Name |
trace amine-associated receptor 7E |
| Synonyms |
LOC276742 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.139)
|
| Stock # |
IGL00494
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
10 |
| Chromosomal Location |
23913512-23914588 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 23914038 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 176
(I176T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000090326
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000092656]
|
| AlphaFold |
Q5QD09 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000092656
AA Change: I176T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000090326
Gene: ENSMUSG00000100689
AA Change: I176T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
56 |
261 |
5.4e-8 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
58 |
341 |
4.3e-10 |
PFAM |
|
Pfam:7tm_1
|
64 |
326 |
9.4e-59 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 21 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A2m |
A |
G |
6: 121,621,108 (GRCm39) |
T271A |
possibly damaging |
Het |
| Amer3 |
A |
G |
1: 34,627,608 (GRCm39) |
T616A |
probably benign |
Het |
| Cacna1d |
A |
T |
14: 29,818,907 (GRCm39) |
M1216K |
probably damaging |
Het |
| Clec16a |
A |
T |
16: 10,413,760 (GRCm39) |
K389M |
probably damaging |
Het |
| Grin2b |
T |
G |
6: 135,713,329 (GRCm39) |
M851L |
possibly damaging |
Het |
| Hapln1 |
T |
C |
13: 89,753,590 (GRCm39) |
V252A |
probably benign |
Het |
| Hspa13 |
A |
G |
16: 75,554,880 (GRCm39) |
V402A |
possibly damaging |
Het |
| Lrfn1 |
T |
C |
7: 28,159,442 (GRCm39) |
Y454H |
probably damaging |
Het |
| Map3k21 |
G |
A |
8: 126,671,412 (GRCm39) |
S900N |
possibly damaging |
Het |
| Mdm1 |
C |
A |
10: 118,000,346 (GRCm39) |
H615N |
probably damaging |
Het |
| Meak7 |
T |
C |
8: 120,499,334 (GRCm39) |
K53E |
probably benign |
Het |
| Nabp1 |
A |
T |
1: 51,516,687 (GRCm39) |
D60E |
probably damaging |
Het |
| Nmur1 |
T |
C |
1: 86,314,084 (GRCm39) |
E361G |
probably benign |
Het |
| Pms1 |
A |
G |
1: 53,245,715 (GRCm39) |
|
probably benign |
Het |
| Ralgapa1 |
T |
G |
12: 55,793,970 (GRCm39) |
D555A |
probably damaging |
Het |
| Rbbp4 |
T |
C |
4: 129,203,946 (GRCm39) |
E406G |
probably benign |
Het |
| Rp1l1 |
T |
A |
14: 64,266,174 (GRCm39) |
C587S |
probably benign |
Het |
| Sez6l |
A |
T |
5: 112,610,869 (GRCm39) |
N516K |
probably damaging |
Het |
| Tex14 |
G |
T |
11: 87,446,310 (GRCm39) |
R1439S |
probably damaging |
Het |
| Tle3 |
T |
A |
9: 61,316,039 (GRCm39) |
|
probably benign |
Het |
| Xntrpc |
T |
A |
7: 101,736,754 (GRCm39) |
L327Q |
probably damaging |
Het |
|
| Other mutations in Taar7e |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03150:Taar7e
|
APN |
10 |
23,913,528 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03366:Taar7e
|
APN |
10 |
23,913,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2013:Taar7e
|
UTSW |
10 |
23,913,732 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2095:Taar7e
|
UTSW |
10 |
23,913,949 (GRCm39) |
nonsense |
probably null |
|
|
R4210:Taar7e
|
UTSW |
10 |
23,913,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4211:Taar7e
|
UTSW |
10 |
23,913,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4766:Taar7e
|
UTSW |
10 |
23,914,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6085:Taar7e
|
UTSW |
10 |
23,913,761 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6117:Taar7e
|
UTSW |
10 |
23,914,427 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6918:Taar7e
|
UTSW |
10 |
23,913,513 (GRCm39) |
start codon destroyed |
probably null |
0.15 |
|
R7410:Taar7e
|
UTSW |
10 |
23,914,424 (GRCm39) |
missense |
probably benign |
|
|
R7913:Taar7e
|
UTSW |
10 |
23,913,902 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9008:Taar7e
|
UTSW |
10 |
23,913,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9081:Taar7e
|
UTSW |
10 |
23,913,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Taar7e
|
UTSW |
10 |
23,913,972 (GRCm39) |
missense |
probably benign |
|
|
R9360:Taar7e
|
UTSW |
10 |
23,913,949 (GRCm39) |
nonsense |
probably null |
|
|
R9465:Taar7e
|
UTSW |
10 |
23,914,310 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9790:Taar7e
|
UTSW |
10 |
23,913,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9791:Taar7e
|
UTSW |
10 |
23,913,554 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2012-04-20 |
Incidental Mutation