Incidental Mutation 'R2881:Zfp998'
| ID |
477057 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp998
|
| Ensembl Gene |
ENSMUSG00000074832 |
| Gene Name |
zinc finger protein 998 |
| Synonyms |
Gt(Ayu21)35Imeg, Gt(pU21)35Imeg, 2410141K09Rik, Snerv1 |
| MMRRC Submission |
040469-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.119)
|
| Stock # |
R2881 (G1)
|
| Quality Score |
106 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
66566173-66589179 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 66579329 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 385
(C385S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134352
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000091541]
[ENSMUST00000172579]
[ENSMUST00000173583]
|
| AlphaFold |
K7N769 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000091541
|
| SMART Domains |
Protein: ENSMUSP00000089126
Gene: ENSMUSG00000074832
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
6.16e-15 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000172579
AA Change: C385S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000134352
Gene: ENSMUSG00000074832
AA Change: C385S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
3.3e-15 |
SMART |
|
ZnF_C2H2
|
75 |
97 |
1.72e-4 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.06e-4 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
5.81e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173583
|
| SMART Domains |
Protein: ENSMUSP00000134048
Gene: ENSMUSG00000074832
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
6.16e-15 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000225647
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atp4a |
G |
A |
7: 30,419,650 (GRCm39) |
R671Q |
probably benign |
Het |
| Atp9a |
T |
C |
2: 168,548,134 (GRCm39) |
Y7C |
probably damaging |
Het |
| Bsn |
C |
T |
9: 107,990,266 (GRCm39) |
A1829T |
possibly damaging |
Het |
| Camta2 |
A |
T |
11: 70,570,490 (GRCm39) |
|
probably null |
Het |
| Ces1d |
C |
A |
8: 93,921,659 (GRCm39) |
G35W |
probably damaging |
Het |
| Chd3 |
T |
C |
11: 69,242,946 (GRCm39) |
D1425G |
probably damaging |
Het |
| Coasy |
G |
A |
11: 100,976,675 (GRCm39) |
V482I |
possibly damaging |
Het |
| Cyp2j9 |
A |
T |
4: 96,462,249 (GRCm39) |
V344E |
probably damaging |
Het |
| Dhx30 |
A |
T |
9: 109,927,913 (GRCm39) |
Y73* |
probably null |
Het |
| Ewsr1 |
C |
A |
11: 5,028,523 (GRCm39) |
|
probably benign |
Het |
| Faap100 |
T |
C |
11: 120,265,185 (GRCm39) |
T564A |
probably damaging |
Het |
| Galc |
A |
G |
12: 98,179,355 (GRCm39) |
M518T |
probably benign |
Het |
| Gpatch8 |
A |
G |
11: 102,370,743 (GRCm39) |
Y932H |
unknown |
Het |
| Hace1 |
T |
A |
10: 45,547,230 (GRCm39) |
M471K |
probably benign |
Het |
| Irf2bpl |
T |
A |
12: 86,929,551 (GRCm39) |
D374V |
probably damaging |
Het |
| Lcor |
A |
G |
19: 41,571,488 (GRCm39) |
E227G |
probably damaging |
Het |
| Nbea |
A |
G |
3: 55,554,779 (GRCm39) |
V2623A |
probably benign |
Het |
| Or4a47 |
T |
C |
2: 89,675,328 (GRCm39) |
|
probably null |
Het |
| Or5ac24 |
A |
T |
16: 59,165,215 (GRCm39) |
L283Q |
probably damaging |
Het |
| Pex5l |
T |
A |
3: 33,047,152 (GRCm39) |
|
probably null |
Het |
| Pira13 |
T |
A |
7: 3,828,640 (GRCm39) |
M1L |
probably null |
Het |
| Plxnb1 |
T |
A |
9: 108,943,480 (GRCm39) |
S1908T |
probably damaging |
Het |
| Sgo2b |
T |
C |
8: 64,380,570 (GRCm39) |
Y754C |
probably damaging |
Het |
| She |
T |
A |
3: 89,739,231 (GRCm39) |
C141S |
probably benign |
Het |
| Tex15 |
T |
A |
8: 34,064,935 (GRCm39) |
L1455* |
probably null |
Het |
| Tfec |
T |
A |
6: 16,835,232 (GRCm39) |
H182L |
probably benign |
Het |
| Tgm6 |
T |
C |
2: 129,979,359 (GRCm39) |
V163A |
probably benign |
Het |
| Vmn2r88 |
G |
T |
14: 51,656,146 (GRCm39) |
C794F |
probably damaging |
Het |
| Zfp871 |
T |
C |
17: 32,994,407 (GRCm39) |
K256R |
probably damaging |
Het |
|
| Other mutations in Zfp998 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R2698:Zfp998
|
UTSW |
13 |
66,581,495 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5217:Zfp998
|
UTSW |
13 |
66,581,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5401:Zfp998
|
UTSW |
13 |
66,579,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5429:Zfp998
|
UTSW |
13 |
66,579,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5532:Zfp998
|
UTSW |
13 |
66,579,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5626:Zfp998
|
UTSW |
13 |
66,580,040 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5686:Zfp998
|
UTSW |
13 |
66,579,722 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6151:Zfp998
|
UTSW |
13 |
66,579,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6173:Zfp998
|
UTSW |
13 |
66,579,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6857:Zfp998
|
UTSW |
13 |
66,580,161 (GRCm39) |
missense |
probably benign |
|
|
R7405:Zfp998
|
UTSW |
13 |
66,579,118 (GRCm39) |
missense |
unknown |
|
|
R7737:Zfp998
|
UTSW |
13 |
66,581,738 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8482:Zfp998
|
UTSW |
13 |
66,579,797 (GRCm39) |
intron |
probably benign |
|
|
R9260:Zfp998
|
UTSW |
13 |
66,579,375 (GRCm39) |
missense |
unknown |
|
|
Z1088:Zfp998
|
UTSW |
13 |
66,579,800 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Zfp998
|
UTSW |
13 |
66,579,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
|
| Posted On |
2017-05-15 |
Incidental Mutation