Incidental Mutation 'R6227:Zfp213'
ID 504430
Institutional Source Beutler Lab
Gene Symbol Zfp213
Ensembl Gene ENSMUSG00000071256
Gene Name zinc finger protein 213
Synonyms D17Ertd197e
MMRRC Submission 044398-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R6227 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 23775741-23783200 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 23776996 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 349 (T349A)
Ref Sequence ENSEMBL: ENSMUSP00000093266 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088673] [ENSMUST00000095606] [ENSMUST00000182769]
AlphaFold E9QAW0
Predicted Effect probably benign
Transcript: ENSMUST00000088673
SMART Domains Protein: ENSMUSP00000086048
Gene: ENSMUSG00000067882

DomainStartEndE-ValueType
Pfam:Peptidase_C14 3 162 4.5e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000095606
AA Change: T349A

PolyPhen 2 Score 0.161 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000093266
Gene: ENSMUSG00000071256
AA Change: T349A

DomainStartEndE-ValueType
SCAN 41 145 3.11e-56 SMART
KRAB 213 278 3.21e-4 SMART
ZnF_C2H2 326 348 3.89e-3 SMART
ZnF_C2H2 354 376 9.88e-5 SMART
ZnF_C2H2 382 404 6.42e-4 SMART
ZnF_C2H2 410 432 1.95e-3 SMART
ZnF_C2H2 438 460 4.4e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180920
Predicted Effect probably benign
Transcript: ENSMUST00000182769
SMART Domains Protein: ENSMUSP00000138283
Gene: ENSMUSG00000067882

DomainStartEndE-ValueType
Pfam:Peptidase_C14 18 175 1.7e-7 PFAM
Meta Mutation Damage Score 0.0630 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.4%
Validation Efficiency 97% (61/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921504E06Rik T C 2: 19,558,581 (GRCm39) probably null Het
Abca4 T A 3: 121,930,743 (GRCm39) Y205* probably null Het
Adgrf1 A G 17: 43,621,164 (GRCm39) D467G probably benign Het
Atp7b T C 8: 22,510,841 (GRCm39) D550G possibly damaging Het
Bicd1 T A 6: 149,414,674 (GRCm39) Y462* probably null Het
Cfap97 T C 8: 46,644,769 (GRCm39) probably null Het
Csf1r T A 18: 61,258,900 (GRCm39) Y706* probably null Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dst A G 1: 34,233,621 (GRCm39) D3443G probably benign Het
Fktn C T 4: 53,731,136 (GRCm39) A96V probably benign Het
Inppl1 G A 7: 101,473,506 (GRCm39) T1048M possibly damaging Het
Itga2 T C 13: 114,976,097 (GRCm39) T1092A probably benign Het
Lactbl1 C A 4: 136,365,229 (GRCm39) A527E probably benign Het
Miga1 C T 3: 151,984,586 (GRCm39) A510T probably benign Het
Mip T A 10: 128,061,875 (GRCm39) L42* probably null Het
Naca T G 10: 127,879,785 (GRCm39) probably benign Het
Or51f5 A T 7: 102,423,883 (GRCm39) I51F probably damaging Het
Or52l1 T C 7: 104,829,917 (GRCm39) Y216C probably damaging Het
Or6c69 T A 10: 129,747,536 (GRCm39) T204S probably damaging Het
Pcm1 T A 8: 41,783,862 (GRCm39) M1986K probably damaging Het
Pex6 T A 17: 47,023,034 (GRCm39) D203E probably benign Het
Rlbp1 T C 7: 79,029,876 (GRCm39) N119S probably benign Het
Rptn C G 3: 93,305,437 (GRCm39) H923Q possibly damaging Het
Rusc1 T A 3: 88,999,048 (GRCm39) T245S probably benign Het
Slc26a5 A T 5: 22,026,095 (GRCm39) C378S probably damaging Het
Smtn A G 11: 3,477,624 (GRCm39) probably benign Het
Tes3-ps T C 13: 49,647,516 (GRCm39) C131R probably damaging Het
Thbs4 T C 13: 92,911,190 (GRCm39) E331G probably null Het
Tlr4 T C 4: 66,758,832 (GRCm39) Y542H probably benign Het
Trf G A 9: 103,107,504 (GRCm39) probably benign Het
Trim75 T A 8: 65,435,748 (GRCm39) H234L probably benign Het
Zan T G 5: 137,466,605 (GRCm39) R417S probably damaging Het
Zfp709 TCGACG TCG 8: 72,644,552 (GRCm39) probably benign Het
Other mutations in Zfp213
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01301:Zfp213 APN 17 23,780,391 (GRCm39) missense probably benign 0.18
IGL02302:Zfp213 APN 17 23,776,945 (GRCm39) missense possibly damaging 0.88
ANU18:Zfp213 UTSW 17 23,780,391 (GRCm39) missense probably benign 0.18
R2137:Zfp213 UTSW 17 23,778,481 (GRCm39) splice site probably null
R4010:Zfp213 UTSW 17 23,777,064 (GRCm39) missense possibly damaging 0.93
R5149:Zfp213 UTSW 17 23,780,373 (GRCm39) missense probably damaging 0.97
R5595:Zfp213 UTSW 17 23,780,160 (GRCm39) missense possibly damaging 0.92
R5979:Zfp213 UTSW 17 23,776,885 (GRCm39) nonsense probably null
R6711:Zfp213 UTSW 17 23,778,485 (GRCm39) missense probably benign
R7105:Zfp213 UTSW 17 23,777,178 (GRCm39) missense probably benign 0.40
R7409:Zfp213 UTSW 17 23,778,603 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- TGCACGCTGCTTGAAACTC -3'
(R):5'- TATGTCCTGGAATCCCGAGG -3'

Sequencing Primer
(F):5'- TGCAGCTGAAGGGCTTCTC -3'
(R):5'- ATCCCGAGGAGGCTGAGAC -3'
Posted On 2018-02-28