Incidental Mutation 'IGL01145:Dkk4'
ID 51834
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dkk4
Ensembl Gene ENSMUSG00000031535
Gene Name dickkopf WNT signaling pathway inhibitor 4
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01145
Quality Score
Status
Chromosome 8
Chromosomal Location 23114059-23117563 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 23115402 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 84 (V84D)
Ref Sequence ENSEMBL: ENSMUSP00000033936 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033936] [ENSMUST00000033938]
AlphaFold Q8VEJ3
Predicted Effect probably damaging
Transcript: ENSMUST00000033936
AA Change: V84D

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000033936
Gene: ENSMUSG00000031535
AA Change: V84D

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Dickkopf_N 40 91 2e-18 PFAM
Pfam:Prokineticin 135 213 2.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000033938
SMART Domains Protein: ENSMUSP00000033938
Gene: ENSMUSG00000031536

DomainStartEndE-ValueType
POLXc 10 334 4.58e-159 SMART
HhH1 57 76 1.91e-1 SMART
HhH1 98 117 1.14e1 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional ready allele are phenotypically normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan A C 7: 78,749,030 (GRCm39) D1267A probably damaging Het
Ankrd44 A G 1: 54,801,418 (GRCm39) probably null Het
Arap3 T C 18: 38,122,232 (GRCm39) M619V probably benign Het
C8b A T 4: 104,637,777 (GRCm39) Y83F probably benign Het
Capn15 A G 17: 26,182,024 (GRCm39) V595A probably damaging Het
Cbx1 A T 11: 96,692,392 (GRCm39) D93V probably benign Het
Cyp2c66 G T 19: 39,159,405 (GRCm39) E285D probably benign Het
Dnah17 T A 11: 117,937,999 (GRCm39) I3343F possibly damaging Het
Dus3l T C 17: 57,074,627 (GRCm39) probably benign Het
Ecpas A C 4: 58,811,501 (GRCm39) D1467E probably null Het
Eif6 A G 2: 155,668,355 (GRCm39) probably benign Het
Eya3 A G 4: 132,437,306 (GRCm39) I389V probably damaging Het
Gm5916 A T 9: 36,031,998 (GRCm39) D95E unknown Het
Gucy2d T A 7: 98,099,170 (GRCm39) S329T probably benign Het
Hook3 C T 8: 26,549,372 (GRCm39) M157I probably benign Het
Iapp C A 6: 142,249,090 (GRCm39) R48S probably damaging Het
Ints11 A G 4: 155,969,583 (GRCm39) Y153C probably damaging Het
Layn G A 9: 50,985,346 (GRCm39) T62I probably benign Het
Llgl2 A G 11: 115,744,631 (GRCm39) H876R probably benign Het
Lrp4 T C 2: 91,317,396 (GRCm39) I840T probably damaging Het
Myo9a T A 9: 59,762,658 (GRCm39) F796L probably benign Het
Naip1 A G 13: 100,545,629 (GRCm39) S1300P probably benign Het
Nfat5 T A 8: 108,093,847 (GRCm39) I602N probably damaging Het
Omt2a T C 9: 78,220,238 (GRCm39) M64V probably benign Het
Pcnx1 T C 12: 82,038,809 (GRCm39) S2025P probably damaging Het
Pemt A G 11: 59,874,293 (GRCm39) L62P probably damaging Het
Polrmt A G 10: 79,576,971 (GRCm39) V399A probably benign Het
Rasgrp4 T C 7: 28,850,898 (GRCm39) S77P possibly damaging Het
Rrm2b G A 15: 37,944,804 (GRCm39) P111L probably damaging Het
Slc10a4-ps A T 5: 72,743,547 (GRCm39) probably null Het
Thap12 A G 7: 98,362,110 (GRCm39) *121W probably null Het
Tnik A G 3: 28,658,316 (GRCm39) probably benign Het
Trio G A 15: 27,818,253 (GRCm39) probably benign Het
Zfhx4 A G 3: 5,310,407 (GRCm39) E930G probably damaging Het
Zfp335 G T 2: 164,749,422 (GRCm39) T299K probably benign Het
Other mutations in Dkk4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01086:Dkk4 APN 8 23,116,857 (GRCm39) missense probably damaging 1.00
R0504:Dkk4 UTSW 8 23,115,359 (GRCm39) missense probably damaging 1.00
R4689:Dkk4 UTSW 8 23,115,336 (GRCm39) missense probably benign 0.05
R5014:Dkk4 UTSW 8 23,115,315 (GRCm39) missense probably benign 0.08
R5257:Dkk4 UTSW 8 23,117,031 (GRCm39) missense probably damaging 1.00
R5258:Dkk4 UTSW 8 23,117,031 (GRCm39) missense probably damaging 1.00
R5788:Dkk4 UTSW 8 23,115,347 (GRCm39) missense probably damaging 1.00
R7405:Dkk4 UTSW 8 23,115,859 (GRCm39) missense probably benign 0.05
R7964:Dkk4 UTSW 8 23,115,368 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21