Incidental Mutation 'R6673:Tmem33'
ID 527191
Institutional Source Beutler Lab
Gene Symbol Tmem33
Ensembl Gene ENSMUSG00000037720
Gene Name transmembrane protein 33
Synonyms 2700052H22Rik, 5430406L04Rik, 1110006G02Rik, 1600019D15Rik, 2410089A21Rik
MMRRC Submission 044793-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.171) question?
Stock # R6673 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 67417908-67448804 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 67443468 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 215 (V215A)
Ref Sequence ENSEMBL: ENSMUSP00000124390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037918] [ENSMUST00000160352] [ENSMUST00000161369] [ENSMUST00000201979]
AlphaFold Q9CR67
Predicted Effect probably benign
Transcript: ENSMUST00000037918
AA Change: V215A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000042852
Gene: ENSMUSG00000037720
AA Change: V215A

DomainStartEndE-ValueType
Pfam:UPF0121 1 247 9.8e-126 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160352
AA Change: V215A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000124766
Gene: ENSMUSG00000037720
AA Change: V215A

DomainStartEndE-ValueType
Pfam:UPF0121 1 246 2.8e-126 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161369
AA Change: V215A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000124390
Gene: ENSMUSG00000037720
AA Change: V215A

DomainStartEndE-ValueType
Pfam:UPF0121 7 245 1.8e-100 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201979
SMART Domains Protein: ENSMUSP00000144531
Gene: ENSMUSG00000037720

DomainStartEndE-ValueType
Pfam:UPF0121 7 61 5.9e-7 PFAM
Meta Mutation Damage Score 0.0691 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armh4 T A 14: 50,008,049 (GRCm39) M475L probably benign Het
Cenpb A T 2: 131,021,165 (GRCm39) L211H probably damaging Het
Ckmt1 C T 2: 121,190,151 (GRCm39) P82S probably damaging Het
Cspg4b C T 13: 113,504,366 (GRCm39) Q1832* probably null Het
Fbxo38 A G 18: 62,666,986 (GRCm39) C138R probably damaging Het
Hkdc1 A G 10: 62,239,385 (GRCm39) V306A probably damaging Het
Mecom T C 3: 30,034,851 (GRCm39) N275S probably benign Het
Mpdz T C 4: 81,274,667 (GRCm39) D185G probably benign Het
Prtg T A 9: 72,758,964 (GRCm39) N439K probably damaging Het
Rsf1 GGCGGCGG GGCGGCGGGGGCGGCGG 7: 97,229,125 (GRCm39) probably benign Het
Serpina3b A G 12: 104,096,928 (GRCm39) N70D probably damaging Het
Shc1 T C 3: 89,329,269 (GRCm39) S38P possibly damaging Het
Slc13a2 T A 11: 78,288,657 (GRCm39) I540F probably benign Het
Trappc8 A G 18: 21,018,314 (GRCm39) V53A probably benign Het
Trim41 TTCCTCCTCCTCCTCCTCCTCCTCCTCC TTCCTCCTCCTCCTCCTCCTCCTCC 11: 48,707,084 (GRCm39) probably benign Het
Other mutations in Tmem33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00499:Tmem33 APN 5 67,441,538 (GRCm39) missense probably damaging 1.00
IGL02076:Tmem33 APN 5 67,443,446 (GRCm39) missense probably damaging 1.00
IGL03106:Tmem33 APN 5 67,421,139 (GRCm39) missense probably damaging 1.00
commonplace UTSW 5 67,421,802 (GRCm39) critical splice donor site probably null
R0573:Tmem33 UTSW 5 67,421,603 (GRCm39) intron probably benign
R0839:Tmem33 UTSW 5 67,421,651 (GRCm39) missense probably damaging 1.00
R1129:Tmem33 UTSW 5 67,421,803 (GRCm39) splice site probably null
R1438:Tmem33 UTSW 5 67,424,634 (GRCm39) splice site probably null
R1692:Tmem33 UTSW 5 67,425,897 (GRCm39) missense probably null 0.57
R4513:Tmem33 UTSW 5 67,443,468 (GRCm39) missense probably benign 0.02
R4763:Tmem33 UTSW 5 67,443,479 (GRCm39) missense probably benign 0.22
R6298:Tmem33 UTSW 5 67,425,894 (GRCm39) nonsense probably null
R6813:Tmem33 UTSW 5 67,421,802 (GRCm39) critical splice donor site probably null
R7186:Tmem33 UTSW 5 67,421,130 (GRCm39) missense possibly damaging 0.68
R7378:Tmem33 UTSW 5 67,443,476 (GRCm39) missense probably benign
R8402:Tmem33 UTSW 5 67,424,718 (GRCm39) splice site probably benign
R9747:Tmem33 UTSW 5 67,425,922 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- CGCAGTGTACTCCAGATTCATC -3'
(R):5'- TTTGGGACCCCTATCAGAATTAC -3'

Sequencing Primer
(F):5'- ACTTACTATGTACACCAGGCTGG -3'
(R):5'- TAAAGGCGATGCTCTGGA -3'
Posted On 2018-07-23