Incidental Mutation 'R6684:Polr3g'
ID 527628
Institutional Source Beutler Lab
Gene Symbol Polr3g
Ensembl Gene ENSMUSG00000035834
Gene Name polymerase (RNA) III (DNA directed) polypeptide G
Synonyms RPC32, 2310047G20Rik
MMRRC Submission 044803-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6684 (G1)
Quality Score 116.008
Status Validated
Chromosome 13
Chromosomal Location 81821962-81859132 bp(-) (GRCm39)
Type of Mutation splice site (213 bp from exon)
DNA Base Change (assembly) A to T at 81847650 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125054 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048993] [ENSMUST00000161920]
AlphaFold Q6NXY9
Predicted Effect probably null
Transcript: ENSMUST00000048993
SMART Domains Protein: ENSMUSP00000035289
Gene: ENSMUSG00000035834

DomainStartEndE-ValueType
Pfam:RNA_pol_3_Rpc31 1 223 7e-41 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160331
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161093
SMART Domains Protein: ENSMUSP00000124885
Gene: ENSMUSG00000035834

DomainStartEndE-ValueType
Pfam:RNA_pol_3_Rpc31 1 83 1.6e-14 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000161920
SMART Domains Protein: ENSMUSP00000125054
Gene: ENSMUSG00000035834

DomainStartEndE-ValueType
Pfam:RNA_pol_3_Rpc31 1 105 1e-13 PFAM
transmembrane domain 136 158 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 94% (33/35)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcf2 G A 5: 24,774,137 (GRCm39) R322W probably damaging Het
Capns1 C A 7: 29,893,324 (GRCm39) G63V probably damaging Het
Carmil1 G A 13: 24,206,525 (GRCm39) T5M unknown Het
Cr2 T A 1: 194,853,329 (GRCm39) K70* probably null Het
Dapk1 T A 13: 60,908,708 (GRCm39) I1107N probably damaging Het
Ehd4 A G 2: 119,984,815 (GRCm39) F48L probably damaging Het
Fam221a G T 6: 49,349,542 (GRCm39) E36* probably null Het
Fam81b G A 13: 76,350,157 (GRCm39) Q423* probably null Het
Galnt7 C T 8: 57,991,143 (GRCm39) V456I probably benign Het
Gm10801 C CGTA 2: 98,494,152 (GRCm39) probably null Het
Hrc A G 7: 44,985,956 (GRCm39) H369R possibly damaging Het
Impg2 T G 16: 56,080,292 (GRCm39) S590A probably benign Het
Lcn3 A T 2: 25,656,170 (GRCm39) H75L probably benign Het
Lims1 T A 10: 58,234,835 (GRCm39) probably null Het
Lkaaear1 TCTCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTCCAG TCTCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTCCAGCTCCAG 2: 181,339,354 (GRCm39) probably benign Het
Or5p79 A G 7: 108,221,141 (GRCm39) T41A probably damaging Het
Orai3 A G 7: 127,372,892 (GRCm39) N131S probably damaging Het
Pcdhga7 T C 18: 37,849,103 (GRCm39) L370P probably damaging Het
Phtf2 A G 5: 21,017,937 (GRCm39) probably benign Het
Plcg2 T C 8: 118,323,071 (GRCm39) Y709H probably damaging Het
Pmfbp1 T C 8: 110,262,462 (GRCm39) S719P probably benign Het
Ppp4r1 G A 17: 66,131,337 (GRCm39) A360T probably benign Het
Pramel6 T C 2: 87,339,748 (GRCm39) W171R probably damaging Het
Rad54b T C 4: 11,583,689 (GRCm39) probably benign Het
Rasl10a G A 11: 5,008,396 (GRCm39) E31K possibly damaging Het
Ryr3 T C 2: 112,583,433 (GRCm39) R2813G probably damaging Het
Tmem71 A G 15: 66,413,539 (GRCm39) S178P possibly damaging Het
Trim58 A G 11: 58,542,446 (GRCm39) T469A probably benign Het
Vash1 A G 12: 86,735,683 (GRCm39) T190A probably damaging Het
Ythdc2 T C 18: 45,006,136 (GRCm39) S1210P possibly damaging Het
Zfp42 G A 8: 43,749,093 (GRCm39) T136M possibly damaging Het
Zfp595 T C 13: 67,468,341 (GRCm39) Y72C probably damaging Het
Other mutations in Polr3g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00886:Polr3g APN 13 81,842,796 (GRCm39) missense probably damaging 1.00
IGL01764:Polr3g APN 13 81,830,238 (GRCm39) missense possibly damaging 0.93
R0118:Polr3g UTSW 13 81,824,240 (GRCm39) unclassified probably benign
R0550:Polr3g UTSW 13 81,842,892 (GRCm39) missense probably damaging 0.99
R3725:Polr3g UTSW 13 81,842,754 (GRCm39) missense probably damaging 0.99
R6536:Polr3g UTSW 13 81,826,335 (GRCm39) missense unknown
R7645:Polr3g UTSW 13 81,842,563 (GRCm39) missense unknown
R8296:Polr3g UTSW 13 81,842,682 (GRCm39) missense unknown
R8317:Polr3g UTSW 13 81,826,302 (GRCm39) missense unknown
R9178:Polr3g UTSW 13 81,842,535 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ACATGGCATCATAGTAAGGAGC -3'
(R):5'- TGGGAAAGTGCAGTTCTGC -3'

Sequencing Primer
(F):5'- TGGCATCATAGTAAGGAGCAAAATC -3'
(R):5'- AAAGTGCAGTTCTGCTTAGGGC -3'
Posted On 2018-07-23