Incidental Mutation 'R6739:Or10a5'
| ID |
530356 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Or10a5
|
| Ensembl Gene |
ENSMUSG00000073898 |
| Gene Name |
olfactory receptor family 10 subfamily A member 5 |
| Synonyms |
MOR263-1, Olfr713, P3, GA_x6K02T2PBJ9-9415724-9416677 |
| MMRRC Submission |
044857-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.063)
|
| Stock # |
R6739 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
106635343-106636317 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 106636018 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 219
(Y219H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150042
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098139]
[ENSMUST00000213623]
|
| AlphaFold |
Q920G5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000098139
AA Change: Y226H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000095743
Gene: ENSMUSG00000073898
AA Change: Y226H
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
39 |
316 |
4.4e-57 |
PFAM |
|
Pfam:7tm_1
|
49 |
298 |
2e-23 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000213623
AA Change: Y219H
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 96.0%
|
| Validation Efficiency |
97% (33/34) |
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter allele exhibit abnormal olfactory sensory neuron projections. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy9 |
A |
G |
16: 4,236,658 (GRCm39) |
V14A |
probably benign |
Het |
| Ank2 |
A |
T |
3: 126,873,643 (GRCm39) |
N59K |
probably damaging |
Het |
| Ano4 |
T |
C |
10: 88,863,114 (GRCm39) |
Y286C |
probably damaging |
Het |
| Arhgap21 |
G |
A |
2: 20,885,543 (GRCm39) |
H545Y |
possibly damaging |
Het |
| Arid1a |
T |
A |
4: 133,414,937 (GRCm39) |
S1152C |
unknown |
Het |
| Cfap73 |
T |
C |
5: 120,768,258 (GRCm39) |
T167A |
probably benign |
Het |
| Ctbs |
A |
T |
3: 146,165,254 (GRCm39) |
|
probably null |
Het |
| Dmgdh |
T |
A |
13: 93,857,123 (GRCm39) |
N742K |
probably benign |
Het |
| Dmxl1 |
T |
C |
18: 50,011,313 (GRCm39) |
S1157P |
probably benign |
Het |
| Dnm3 |
T |
C |
1: 162,305,352 (GRCm39) |
N14S |
probably damaging |
Het |
| Dpp4 |
C |
T |
2: 62,217,439 (GRCm39) |
V53I |
probably benign |
Het |
| Etl4 |
A |
G |
2: 20,718,246 (GRCm39) |
N329S |
probably damaging |
Het |
| Fbxw25 |
A |
G |
9: 109,480,699 (GRCm39) |
V327A |
probably benign |
Het |
| Gsg1 |
T |
A |
6: 135,214,612 (GRCm39) |
Q299L |
probably damaging |
Het |
| Igsf23 |
A |
G |
7: 19,678,673 (GRCm39) |
L39P |
probably damaging |
Het |
| Il17rd |
A |
G |
14: 26,821,488 (GRCm39) |
R261G |
possibly damaging |
Het |
| Krt75 |
C |
T |
15: 101,479,503 (GRCm39) |
D276N |
probably benign |
Het |
| Lox |
T |
C |
18: 52,660,031 (GRCm39) |
T268A |
possibly damaging |
Het |
| Mroh4 |
T |
C |
15: 74,481,568 (GRCm39) |
S825G |
probably benign |
Het |
| Nlrp9c |
T |
C |
7: 26,084,850 (GRCm39) |
D243G |
probably damaging |
Het |
| Or1x6 |
T |
A |
11: 50,939,564 (GRCm39) |
V210E |
probably damaging |
Het |
| Picalm |
C |
A |
7: 89,825,916 (GRCm39) |
T131N |
probably damaging |
Het |
| Pitpnm1 |
T |
A |
19: 4,160,522 (GRCm39) |
L781H |
probably damaging |
Het |
| Proz |
A |
T |
8: 13,123,451 (GRCm39) |
I241F |
possibly damaging |
Het |
| Rb1cc1 |
A |
G |
1: 6,304,454 (GRCm39) |
D67G |
probably damaging |
Het |
| Rnf213 |
T |
A |
11: 119,333,097 (GRCm39) |
C2769S |
probably damaging |
Het |
| Rsf1 |
G |
GACGGCGGCT |
7: 97,229,116 (GRCm39) |
|
probably benign |
Het |
| Scn8a |
T |
C |
15: 100,913,836 (GRCm39) |
I1076T |
possibly damaging |
Het |
| Snrnp70 |
A |
T |
7: 45,036,843 (GRCm39) |
D100E |
probably damaging |
Het |
| Triobp |
T |
A |
15: 78,850,566 (GRCm39) |
L240Q |
possibly damaging |
Het |
| Vmn2r5 |
A |
G |
3: 64,398,637 (GRCm39) |
S781P |
probably damaging |
Het |
| Zfp451 |
A |
G |
1: 33,842,675 (GRCm39) |
|
probably benign |
Het |
| Zfta |
C |
T |
19: 7,398,712 (GRCm39) |
R243* |
probably null |
Het |
|
| Other mutations in Or10a5 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01324:Or10a5
|
APN |
7 |
106,636,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01630:Or10a5
|
APN |
7 |
106,636,318 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL02539:Or10a5
|
APN |
7 |
106,635,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02727:Or10a5
|
APN |
7 |
106,635,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03336:Or10a5
|
APN |
7 |
106,635,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0501:Or10a5
|
UTSW |
7 |
106,635,439 (GRCm39) |
missense |
probably benign |
|
|
R0684:Or10a5
|
UTSW |
7 |
106,635,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0909:Or10a5
|
UTSW |
7 |
106,635,401 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1481:Or10a5
|
UTSW |
7 |
106,635,356 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1958:Or10a5
|
UTSW |
7 |
106,635,478 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1965:Or10a5
|
UTSW |
7 |
106,635,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2119:Or10a5
|
UTSW |
7 |
106,635,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2149:Or10a5
|
UTSW |
7 |
106,635,545 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3012:Or10a5
|
UTSW |
7 |
106,635,569 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3428:Or10a5
|
UTSW |
7 |
106,635,923 (GRCm39) |
missense |
probably benign |
|
|
R4425:Or10a5
|
UTSW |
7 |
106,635,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4795:Or10a5
|
UTSW |
7 |
106,636,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4796:Or10a5
|
UTSW |
7 |
106,636,121 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4908:Or10a5
|
UTSW |
7 |
106,635,364 (GRCm39) |
start codon destroyed |
probably benign |
0.02 |
|
R4945:Or10a5
|
UTSW |
7 |
106,635,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5122:Or10a5
|
UTSW |
7 |
106,636,055 (GRCm39) |
nonsense |
probably null |
|
|
R5721:Or10a5
|
UTSW |
7 |
106,635,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5979:Or10a5
|
UTSW |
7 |
106,635,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6981:Or10a5
|
UTSW |
7 |
106,635,956 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7197:Or10a5
|
UTSW |
7 |
106,635,364 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7228:Or10a5
|
UTSW |
7 |
106,636,307 (GRCm39) |
missense |
probably benign |
|
|
R7444:Or10a5
|
UTSW |
7 |
106,635,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8830:Or10a5
|
UTSW |
7 |
106,635,889 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9109:Or10a5
|
UTSW |
7 |
106,635,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9298:Or10a5
|
UTSW |
7 |
106,635,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCAGACCACATGGCTCTTC -3'
(R):5'- GCTATAGATGATGGGGTTCAACATG -3'
Sequencing Primer
(F):5'- AGACCACATGGCTCTTCAGTTTTC -3'
(R):5'- GTTCAACATGGGAGTCACAAC -3'
|
| Posted On |
2018-08-01 |
Incidental Mutation