Incidental Mutation 'R6760:Calm2'
ID 531207
Institutional Source Beutler Lab
Gene Symbol Calm2
Ensembl Gene ENSMUSG00000036438
Gene Name calmodulin 2
Synonyms 1500001E21Rik
MMRRC Submission 044876-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6760 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 87740840-87754363 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87743123 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 65 (D65G)
Ref Sequence ENSEMBL: ENSMUSP00000048857 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040440]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000040440
AA Change: D65G

PolyPhen 2 Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000048857
Gene: ENSMUSG00000036438
AA Change: D65G

DomainStartEndE-ValueType
EFh 12 40 6.39e-9 SMART
EFh 48 76 5.19e-9 SMART
EFh 85 113 3.67e-9 SMART
EFh 121 149 1.13e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143965
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150137
Meta Mutation Damage Score 0.5322 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.8%
Validation Efficiency 97% (35/36)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aco1 C A 4: 40,180,210 (GRCm39) C370* probably null Het
Akap6 C T 12: 53,186,561 (GRCm39) S1325L probably damaging Het
Atp2a3 A G 11: 72,873,566 (GRCm39) D813G probably damaging Het
Baz2b T A 2: 59,792,776 (GRCm39) I451F probably benign Het
Cdh23 C T 10: 60,141,947 (GRCm39) V3049M probably damaging Het
Cfap46 A G 7: 139,232,356 (GRCm39) L869P probably damaging Het
Chrna9 T A 5: 66,128,571 (GRCm39) Y260N probably damaging Het
Clock G A 5: 76,374,823 (GRCm39) P782L unknown Het
Coro2a A G 4: 46,540,572 (GRCm39) M449T probably benign Het
Crispld1 T G 1: 17,821,025 (GRCm39) V355G possibly damaging Het
Dnah7c C A 1: 46,688,500 (GRCm39) T1890K probably benign Het
Dnah7c A G 1: 46,688,511 (GRCm39) S1894G probably benign Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Gpr37 T C 6: 25,669,168 (GRCm39) I559V probably benign Het
Grik5 A G 7: 24,758,364 (GRCm39) probably null Het
Itga8 T C 2: 12,306,451 (GRCm39) Y48C probably damaging Het
Manba T C 3: 135,248,212 (GRCm39) V367A probably damaging Het
Mrgpra1 G A 7: 46,984,789 (GRCm39) R297W probably benign Het
Myh7b C A 2: 155,462,038 (GRCm39) Y311* probably null Het
Nmd3 T A 3: 69,654,170 (GRCm39) probably null Het
Or5m9 T A 2: 85,877,358 (GRCm39) C177* probably null Het
Pakap T C 4: 57,856,026 (GRCm39) W493R probably damaging Het
Pcdhb11 A T 18: 37,554,637 (GRCm39) probably benign Het
Plcb1 C T 2: 135,313,980 (GRCm39) T1144M possibly damaging Het
Sfrp1 A G 8: 23,901,904 (GRCm39) D35G probably damaging Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Timeless A G 10: 128,081,986 (GRCm39) K537R probably benign Het
Tnrc6a T A 7: 122,771,222 (GRCm39) V1004E probably damaging Het
Tubb4a T C 17: 57,387,796 (GRCm39) E410G possibly damaging Het
U2surp G A 9: 95,375,764 (GRCm39) A143V probably benign Het
Vmn2r118 T A 17: 55,899,714 (GRCm39) H730L possibly damaging Het
Vmn2r28 G A 7: 5,484,229 (GRCm39) T657I probably damaging Het
Ybey A T 10: 76,304,033 (GRCm39) N56K probably benign Het
Other mutations in Calm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
Prosperous UTSW 17 87,743,123 (GRCm39) missense probably benign 0.29
R0184:Calm2 UTSW 17 87,743,269 (GRCm39) missense probably benign 0.12
R2167:Calm2 UTSW 17 87,742,573 (GRCm39) missense probably benign 0.00
R5452:Calm2 UTSW 17 87,743,150 (GRCm39) splice site probably null
R7298:Calm2 UTSW 17 87,750,165 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- GGCACATGACATATGCATCCTC -3'
(R):5'- TCACTATTTGACAAGGACGGG -3'

Sequencing Primer
(F):5'- ATCCTCTGCAGTAAGTTTACACGGG -3'
(R):5'- CTATTTGACAAGGACGGGGATGG -3'
Posted On 2018-08-01