Incidental Mutation 'R6797:Vopp1'
ID 533047
Institutional Source Beutler Lab
Gene Symbol Vopp1
Ensembl Gene ENSMUSG00000037788
Gene Name vesicular, overexpressed in cancer, prosurvival protein 1
Synonyms
MMRRC Submission 044910-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6797 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 57729249-57802110 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 57739492 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 19 (Y19H)
Ref Sequence ENSEMBL: ENSMUSP00000144859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114297] [ENSMUST00000127485] [ENSMUST00000145608] [ENSMUST00000203212] [ENSMUST00000204878]
AlphaFold Q8R1C3
Predicted Effect probably benign
Transcript: ENSMUST00000114297
AA Change: Y86H

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000109936
Gene: ENSMUSG00000037788
AA Change: Y86H

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 59 81 N/A INTRINSIC
low complexity region 115 126 N/A INTRINSIC
low complexity region 149 165 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127485
AA Change: Y86H

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000115377
Gene: ENSMUSG00000037788
AA Change: Y86H

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:WBP-1 37 106 7e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143953
Predicted Effect possibly damaging
Transcript: ENSMUST00000145608
AA Change: Y86H

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000145084
Gene: ENSMUSG00000037788
AA Change: Y86H

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
transmembrane domain 59 81 N/A INTRINSIC
low complexity region 112 121 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000203212
AA Change: Y19H

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
Predicted Effect probably benign
Transcript: ENSMUST00000204878
AA Change: Y19H

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000144953
Gene: ENSMUSG00000037788
AA Change: Y19H

DomainStartEndE-ValueType
low complexity region 48 59 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.8%
  • 20x: 96.8%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1c18 T A 13: 4,195,276 (GRCm39) I61L probably benign Het
Angptl2 T C 2: 33,118,277 (GRCm39) V17A probably benign Het
Casp14 T C 10: 78,550,975 (GRCm39) D70G possibly damaging Het
Cckbr A G 7: 105,083,773 (GRCm39) M234V possibly damaging Het
Cd93 T C 2: 148,284,044 (GRCm39) N434S probably benign Het
Cenpe A T 3: 134,943,899 (GRCm39) Q938L possibly damaging Het
Col6a3 A C 1: 90,731,810 (GRCm39) V1481G probably damaging Het
Dnah5 G T 15: 28,233,384 (GRCm39) E248* probably null Het
Dnah5 G A 15: 28,451,609 (GRCm39) R4349Q probably damaging Het
F11 A G 8: 45,706,092 (GRCm39) Y98H probably benign Het
Fen1 A G 19: 10,178,067 (GRCm39) F126L probably benign Het
Gpr146 G A 5: 139,378,795 (GRCm39) G199D possibly damaging Het
Gramd1b A G 9: 40,219,702 (GRCm39) I324T probably benign Het
H2bc12 A T 13: 22,220,259 (GRCm39) N68I probably benign Het
Hivep1 C A 13: 42,310,557 (GRCm39) S932R probably benign Het
Hk3 A T 13: 55,158,644 (GRCm39) probably null Het
Hspbp1 T A 7: 4,663,781 (GRCm39) M355L possibly damaging Het
Jaml T C 9: 45,000,058 (GRCm39) C77R probably damaging Het
Kmt2e A G 5: 23,687,505 (GRCm39) N452D possibly damaging Het
Krt5 T C 15: 101,621,076 (GRCm39) Y57C unknown Het
Lipn A T 19: 34,058,160 (GRCm39) M294L probably benign Het
Magel2 A G 7: 62,029,907 (GRCm39) E937G unknown Het
Med13l G A 5: 118,897,329 (GRCm39) probably null Het
Mrgprb8 G A 7: 48,038,892 (GRCm39) V188I probably benign Het
Ocln T C 13: 100,676,223 (GRCm39) D90G probably damaging Het
Ofcc1 C T 13: 40,241,423 (GRCm39) R695Q possibly damaging Het
Or11h23 T A 14: 50,948,563 (GRCm39) Y259N probably damaging Het
Or52ab7 G A 7: 102,978,328 (GRCm39) V212I probably benign Het
Otogl G A 10: 107,612,978 (GRCm39) silent Het
Pak5 A T 2: 135,939,454 (GRCm39) H560Q probably damaging Het
Pigg T C 5: 108,480,694 (GRCm39) S493P probably damaging Het
Ppp6r3 A G 19: 3,564,719 (GRCm39) W185R probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Sacs T A 14: 61,450,522 (GRCm39) D4189E probably damaging Het
Serpinb9b A G 13: 33,213,467 (GRCm39) N8S possibly damaging Het
Slit3 A G 11: 35,524,779 (GRCm39) T730A possibly damaging Het
Srgap3 A T 6: 112,806,503 (GRCm39) F53I probably damaging Het
Stc2 T A 11: 31,315,351 (GRCm39) K163* probably null Het
Tasor2 T C 13: 3,626,769 (GRCm39) I1060M probably benign Het
Tlk1 T A 2: 70,568,770 (GRCm39) K411* probably null Het
Ttc27 G T 17: 75,036,883 (GRCm39) L185F probably benign Het
Vmn2r102 C T 17: 19,880,694 (GRCm39) Q12* probably null Het
Vmn2r95 C T 17: 18,672,551 (GRCm39) probably benign Het
Wdr64 T A 1: 175,638,176 (GRCm39) probably null Het
Other mutations in Vopp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00846:Vopp1 APN 6 57,731,465 (GRCm39) unclassified probably benign
IGL03155:Vopp1 APN 6 57,739,492 (GRCm39) missense possibly damaging 0.92
R1233:Vopp1 UTSW 6 57,766,980 (GRCm39) missense probably damaging 0.98
R1708:Vopp1 UTSW 6 57,739,497 (GRCm39) missense probably damaging 1.00
R1916:Vopp1 UTSW 6 57,731,572 (GRCm39) missense probably benign 0.02
R4082:Vopp1 UTSW 6 57,766,964 (GRCm39) nonsense probably null
R4392:Vopp1 UTSW 6 57,739,461 (GRCm39) missense probably damaging 1.00
R4585:Vopp1 UTSW 6 57,731,533 (GRCm39) missense probably damaging 1.00
R4586:Vopp1 UTSW 6 57,731,533 (GRCm39) missense probably damaging 1.00
R4879:Vopp1 UTSW 6 57,739,355 (GRCm39) intron probably benign
R8420:Vopp1 UTSW 6 57,739,379 (GRCm39) makesense probably null
R8927:Vopp1 UTSW 6 57,731,578 (GRCm39) missense probably damaging 0.97
R8928:Vopp1 UTSW 6 57,731,578 (GRCm39) missense probably damaging 0.97
R9273:Vopp1 UTSW 6 57,731,575 (GRCm39) missense possibly damaging 0.69
R9619:Vopp1 UTSW 6 57,731,617 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGTAGCCTGATTTATCTCTTCTAGCAC -3'
(R):5'- TCCTCATGGCTGGAGACTTC -3'

Sequencing Primer
(F):5'- TTCTAGCACACTCTGGGGCATAAG -3'
(R):5'- TCATGGCTGGAGACTTCTCACAG -3'
Posted On 2018-08-29