Incidental Mutation 'IGL01015:Fcgr4'
| ID |
53399 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fcgr4
|
| Ensembl Gene |
ENSMUSG00000059089 |
| Gene Name |
Fc receptor, IgG, low affinity IV |
| Synonyms |
CD16-2, 4833442P21Rik, Fcgr3a, FcgammaRIV |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL01015
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
170846495-170857330 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 170853358 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Glycine
at position 188
(S188G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000077873
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078825]
|
| AlphaFold |
A0A0B4J1G0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000078825
AA Change: S188G
PolyPhen 2
Score 0.720 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000077873
Gene: ENSMUSG00000059089
AA Change: S188G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
IG
|
31 |
104 |
5.79e-9 |
SMART |
|
IG
|
112 |
188 |
1.44e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000083971
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased susceptibility to induced arthritis and nephrotoxic nephritis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 30 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano4 |
A |
G |
10: 88,870,961 (GRCm39) |
Y238H |
probably damaging |
Het |
| Apol7a |
T |
C |
15: 77,274,055 (GRCm39) |
|
probably benign |
Het |
| Cacna1d |
A |
T |
14: 29,773,699 (GRCm39) |
|
probably benign |
Het |
| Col12a1 |
A |
G |
9: 79,541,023 (GRCm39) |
V2368A |
probably damaging |
Het |
| Creb3l4 |
A |
G |
3: 90,150,138 (GRCm39) |
M1T |
probably null |
Het |
| Dpys |
T |
C |
15: 39,710,045 (GRCm39) |
D128G |
probably damaging |
Het |
| Ero1b |
A |
G |
13: 12,616,623 (GRCm39) |
|
probably null |
Het |
| Fcgbpl1 |
T |
C |
7: 27,854,743 (GRCm39) |
C1790R |
probably damaging |
Het |
| Fry |
A |
G |
5: 150,346,252 (GRCm39) |
D1587G |
probably benign |
Het |
| Gm43638 |
T |
A |
5: 87,634,473 (GRCm39) |
R45* |
probably null |
Het |
| Gm7647 |
T |
A |
5: 95,111,746 (GRCm39) |
C152S |
probably benign |
Het |
| Golga3 |
T |
G |
5: 110,335,583 (GRCm39) |
M299R |
probably benign |
Het |
| Iqub |
A |
T |
6: 24,501,005 (GRCm39) |
|
probably benign |
Het |
| Irak3 |
A |
T |
10: 119,978,695 (GRCm39) |
Y493* |
probably null |
Het |
| Jakmip1 |
G |
T |
5: 37,242,750 (GRCm39) |
E13* |
probably null |
Het |
| Morc3 |
G |
A |
16: 93,659,534 (GRCm39) |
C446Y |
probably damaging |
Het |
| Mroh2b |
G |
A |
15: 4,971,024 (GRCm39) |
D1010N |
probably damaging |
Het |
| Or14c44 |
A |
G |
7: 86,061,998 (GRCm39) |
T184A |
probably damaging |
Het |
| Or2y16 |
T |
A |
11: 49,335,201 (GRCm39) |
N174K |
probably damaging |
Het |
| Or5m9 |
A |
T |
2: 85,876,996 (GRCm39) |
M57L |
possibly damaging |
Het |
| Pkhd1 |
G |
A |
1: 20,593,482 (GRCm39) |
H1544Y |
possibly damaging |
Het |
| Rps2-ps10 |
C |
T |
18: 61,392,896 (GRCm39) |
|
probably benign |
Het |
| Smco1 |
T |
C |
16: 32,092,887 (GRCm39) |
V186A |
probably damaging |
Het |
| Snx1 |
C |
T |
9: 66,001,713 (GRCm39) |
E314K |
possibly damaging |
Het |
| Timd2 |
T |
C |
11: 46,567,170 (GRCm39) |
Y255C |
probably benign |
Het |
| Tnc |
A |
T |
4: 63,935,571 (GRCm39) |
I455K |
probably benign |
Het |
| Tsc22d1 |
A |
G |
14: 76,656,181 (GRCm39) |
I31V |
possibly damaging |
Het |
| Tyk2 |
A |
G |
9: 21,031,996 (GRCm39) |
S360P |
probably benign |
Het |
| Uroc1 |
G |
T |
6: 90,335,883 (GRCm39) |
|
probably benign |
Het |
| Vmn1r122 |
A |
T |
7: 20,867,761 (GRCm39) |
V98E |
probably damaging |
Het |
|
| Other mutations in Fcgr4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0193:Fcgr4
|
UTSW |
1 |
170,853,329 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0526:Fcgr4
|
UTSW |
1 |
170,856,760 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1164:Fcgr4
|
UTSW |
1 |
170,856,739 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R1544:Fcgr4
|
UTSW |
1 |
170,847,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1716:Fcgr4
|
UTSW |
1 |
170,847,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Fcgr4
|
UTSW |
1 |
170,856,874 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6012:Fcgr4
|
UTSW |
1 |
170,853,233 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6043:Fcgr4
|
UTSW |
1 |
170,847,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6333:Fcgr4
|
UTSW |
1 |
170,856,838 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7034:Fcgr4
|
UTSW |
1 |
170,847,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7036:Fcgr4
|
UTSW |
1 |
170,847,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8123:Fcgr4
|
UTSW |
1 |
170,847,572 (GRCm39) |
missense |
probably benign |
|
|
R8791:Fcgr4
|
UTSW |
1 |
170,847,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Fcgr4
|
UTSW |
1 |
170,847,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-06-28 |
Incidental Mutation